DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and KNS1

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_013081.1	Gene:	KNS1 / 850641	SGDID:	S000003942	Length:	737	Species:	Saccharomyces cerevisiae

Alignment Length:	786	Identity:	164/786 - (20%)
Similarity:	267/786 - (33%)	Gaps:	254/786 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 QQTQVRPRSRNR-----------------------NMEDLRQEINRDKQRERRD-HSRDRDRRGL 343
            |..|:..|.|:|                       |.|:.|.....|:...|:: ...|..|..|
Yeast     3 QNIQIGTRKRSRANMNNSTTTGPANNTSSNKTFLDNFEETRTNKLLDEMFARQNSFLTDNLRNSL 67

  Fly   344 DRPPPPTDMRPGR-----------ARERDVRPSRMQRSHSRSKFESDRRRERERQKD-------- 389
            |.......:||.:           |.|.|..|..:..:.:.|...:..|.:.:...|
Yeast    68 DLNQADNPLRPRQHQHQLFLDNENAIELDEEPRIINTTINNSNNHNSSRVDEDADDDIIFIKEQP 132

  Fly   390 ------------------------RDRGGGRVGARSGTDNGDRDRYK--GSLSEGQNKLDKES-S 427
                                    .:.|.|.....:.|......::|  .::|..|..|.|.| .
Yeast   133 IQFSSPLILPSSSSINNNNNIVTSNNPGCGTAATSNSTYITTPKKFKKQRTISLPQLPLSKLSYQ 197

  Fly   428 DEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVSYESRSTSQGSSQRERPL 492
            ....||      .|....|:....:...|||...|:..::...:.:|:                |
Yeast   198 SNYFNV------PDQTNAIVPRVTQTENELLHLTGSCAKTLEGNKAVN----------------L 240

  Fly   493 RTPSPTMPCPNP--LISEIPKD----------REDMDNSTSQKTCSAKEKRNEWDMFADQDVDSN 545
            .....|.|..||  .|:.:|:.          |:...|.:|:...|.|               ||
Yeast   241 TIAHSTSPFSNPPAQIASLPQSNLKKQIGSSLRKFTSNGSSESASSNK---------------SN 290

  Fly   546 FDVSRKISPNTIVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDN--RYLVNGYTGQGVFSNVVR 608
            |..                          |.:|:|..:..::..:  |::|....|||.|..|::
Yeast   291 FKT--------------------------DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLK 329

  Fly   609 GRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFE 673
            ..|.......||:|:||..:...:....||.||:.:.:.||:.:|.||.|...|.:|.|:|:|.:
Yeast   330 CIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTD 394

  Fly   674 PLAMNLREVLKKYG--KNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNLI-- 734
            ....::.:.:...|  :..|.||:|:   .:||..::..|...||:|.|:||:|||:.:...|
Yeast   395 LYGRSIYDFMCSNGIARFPGSHIQAI---ARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQ 456

  Fly   735 -----------------------------LKLCDFGSASAISDNEITPYLVS-RFYRSPEIILGI 769
                                         :|:.|||  |||...|..|.::| |.||:|||:||:
Yeast   457 KLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFG--SAIFHYEYHPPVISTRHYRAPEIVLGL 519

  Fly   770 PYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKG-KIPNRIIRKGQFREQH------ 827
            .:.:..|.||..|.:.||..|:.|:....|.:.:.....:.| ..|..||.|..::.:|
Yeast   520 GWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSP 584

  Fly   828 FDQSCNFLYHEIDKLT----------------------------EREKIVVMPVVKPSRSLQQEL 864
            .|.:...:.| .|:.|                            :|..|.:..|:|  :.....|
Yeast   585 SDLNSTVIKH-FDRKTLSLQWPEKNKRGDTITTEKSMKRVLQSCDRLDIYISKVLK--QDYGDSL 646

  Fly   865 IADQNLPDDQHRKVTQLK------------------------------DLLENMFALDPAKRISL 899
            ..:.|||.:::..:...|                              |||..||..||.|||:.
Yeast   647 SINWNLPPEKNWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITA 711

  Fly   900 NQALVH 905
            ..||.|
Yeast   712 KDALDH 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	105/414 (25%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	103/406 (25%)
KNS1	NP_013081.1	PKc_CLK	298..720	CDD:271036	106/428 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810