DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and Cdk12

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001103096.1	Gene:	Cdk12 / 69131	MGIID:	1098802	Length:	1484	Species:	Mus musculus

Alignment Length:	1095	Identity:	222/1095 - (20%)
Similarity:	383/1095 - (34%)	Gaps:	337/1095 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DDKSYDS----------SNNSETEERRAKHKKAK----KHKKHKKS----STGKTEKDRHVHKKQ 49
            ||.|.||          |:..|.||||...:..:    :|.:|::|    .|.:|||::  :::.
Mouse    74 DDISSDSDTFSDDTAFKSDRRENEERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEK--NQEV 136

  Fly    50 KKAKKRPHRTSESTNES--DAPENAKLKLSQNCGLSSKFTEIMQKASRNGADFRVG-----KPLL 107
            .|:.....|.|.|:..|  .:.:..|.:||::....|:.:::.::.:|...:.:.|     |...
Mouse   137 SKSGSMKDRVSGSSKRSVEGSDDYGKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHR 201

  Fly   108 PTDPSSLVEEITKTIQNKMLPVLEVASSSSESDVPADAASPIILSIIEDELNLEELMRQKALLQA 172
            ..:.....:.:....:....|..:.:.||.:.|.|:.|      |..:|    .:|...::...:
Mouse   202 KRETPKSYKTVASPKRRSRSPHRKWSDSSKQDDSPSGA------SYGQD----YDLSPPRSHTSS 256

  Fly   173 RLGAYMSDPEAEDKGDLLPHTHSQQLVVHTKSVLKAVTSVPQP--QPSKSAAPLATATSKHANIK 235
            ...:|...|.:..:...:...:.:      .|..::.|..|.|  :..:|.:|.:.        :
Mouse   257 NYDSYKKSPGSTSRRQSISPPYKE------PSAYQSSTRSPSPYSRRQRSVSPYSR--------R 307

  Fly   236 KSTTHNSNESDVILLDDSSGGQRTPSPTPEKRRRHASPLPAAPRSRCRRDRRSR----DRDRSPP 296
            :|:::           :.||.....||:|..|||.:||. .:.||..|....||    .|.|||.
Mouse   308 RSSSY-----------ERSGSYSGRSPSPYGRRRSSSPF-LSKRSLSRSPLPSRKSMKSRSRSPA 360

  Fly   297 RRRASDQQTQVR---PRSRNRNMEDLRQEINRDKQRERRDHSRDRDRRGLDRPPPPTDMRPGRAR 358
            ..|.|...::.:   .|||:.::..:|..:|.....|.                    .|..:.|
Mouse   361 YSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAEL--------------------SRKKKER 405

  Fly   359 ERDVRPSRMQRSHSRSKFESDRRRERERQKDRDRGGGRVGARSGTDNGDRDRYKGSLSEGQNKLD 423
            ......::|....|:|......::|:...|:           ||.::....|        ..|.:
Mouse   406 AAAAAAAKMDGKESKSSPIILPKKEKLEVKE-----------SGLESKKLPR--------SIKSE 451

  Fly   424 KESSDEEV------NVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVSYESRSTS 482
            |.:.|.|:      |..:....:..:.|:.|..:|...:.||..||....|.....|...|:.|.
Mouse   452 KSTPDTELVTVAHSNPEVKHCLDTGKVRLDENLQKHPAKDLKAQGTKDVKPVAPKEVIVTSKETE 516

  Fly   483 QGSSQRERPL----------------RTP-------------SPTMPCPNPLISEIP-KDREDMD 517
            ....:...||                :||             .|.:|.|.|..|::| .....:.
Mouse   517 TSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQPPLPPPQPPFSQVPVSSTSILP 581

  Fly   518 NSTSQKTCSAKEKRNEWD--------------------------------MFADQDVDSNFDVSR 550
            :|...:|.:...:.|...                                :..|.|:||   ...
Mouse   582 SSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDS---PKE 643

  Fly   551 KISPNTIVQNKHQHENPALTD-------------------------------------------- 571
            .:......:.|.|.....|||
Mouse   644 TLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKICCPRYGER 708

  Fly   572 -----NWDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIR---NNE 628
                 :|           |:...:::.:.|..|:|.:..|.:.:|:..|:. ||:|.:|   ..|
Mouse   709 RQTESDW-----------GKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGEL-VALKKVRLDNEKE 761

  Fly   629 IMHKTGLRELEILKKLND----------ADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVL 683
            ....|.:||::||::|..          .|.:|.....:....|:      :|||.:..:|..:|
Mouse   762 GFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFY------LVFEYMDHDLMGLL 820

  Fly   684 KKYGKNVGL------HIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNLILKLCDFGS 742
            :.     ||      |||   |:.:||...|....|...||.|||..|||:|.:..| ||.|||.
Mouse   821 ES-----GLVHFSEDHIK---SFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQI-KLADFGL 876

  Fly   743 ASAISDNEITPY---LVSRFYRSPEIILGIP-YDYGIDTWSAGCTIYELYTGKILFSGKSNNQML 803
            |...:..|..||   :::.:||.||::||.. |...||.||.||.:.||:|.|.:|........|
Mouse   877 ARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQL 941

  Fly   804 KFFMDVKG-----------KIP--NRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVMPVVK 855
            :....:.|           |:|  |.:..|.|:|.               :|.|....:
Mouse   942 ELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRR---------------RLREEFSFI------ 985

  Fly   856 PSRSLQQELIADQNLPDDQHRKVTQLKDLLENMFALDPAKRISLNQALVHPFIQE 910
            ||.:|                      |||::|..|||:||.:..|.|...|:::
Mouse   986 PSAAL----------------------DLLDHMLTLDPSKRCTAEQTLQSDFLKD 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	96/352 (27%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	95/344 (28%)
Cdk12	NP_001103096.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..465		89/467 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..699		31/218 (14%)
		STKc_CDK12	715..1016	CDD:270847	98/370 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1219..1363
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000