DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7028 and dyrk1b

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	XP_005158271.1	Gene:	dyrk1b / 556212	ZFINID:	ZDB-GENE-060503-499	Length:	833	Species:	Danio rerio

Alignment Length:	531	Identity:	152/531 - (28%)
Similarity:	232/531 - (43%)	Gaps:	108/531 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 QESPAPHN----SVSYES------------------RSTSQGSSQRERPLRTPSPTMPCPNPLIS 507
            :|.|.|.|    ::..||                  :....|||...:|   ||.|:..|..|
Zfish     8 EEKPQPSNRMVANLPTESWIGSPDQNRFLPQSHLLRKPARSGSSSGCKP---PSSTLCQPAAL-- 67

  Fly   508 EIPKDREDMDNSTSQKTCSAKEKR----NEWDMFADQDVDSNFDV----------------SRKI 552
                     ..|.::.|.|::...    |...|...|.|.|:..:                .||:
Zfish    68 ---------GFSPAEPTMSSQHSHPSFSNIHSMADQQQVLSDMTILQRRIPPSFRDPASAPLRKL 123

  Fly   553 SPNTIVQNKH-----------------------QHENPALTDNWDDAEGYYRVRIGEVLDNRYLV 594
            |.:.|...||                       :.|.....|.:||....|.|:.||...:||.:
Zfish   124 SVDLIKTYKHINEVYYTKKKRRAQQVPPEDSSTKKERKVYNDGYDDDNYDYIVKNGEKWLDRYEI 188

  Fly   595 NGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLY 659
            :...|:|.|..||:..|. ..|..||||||:|.:........||.:|:.:|..|.|.:::.:.|.
Zfish   189 DSLIGKGSFGQVVKAYDH-HEQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMKYYIVHLK 252

  Fly   660 RHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLL--KKTGILHADIK 722
            |||..:.|||:|||.|:.||.::|:..... |:.:...|.:.|||..||..|  .:..|:|.|:|
Zfish   253 RHFMFRNHLCLVFELLSYNLYDLLRNTNFR-GVSLNLTRKFAQQLCTALLFLATPELSIIHCDLK 316

  Fly   723 PDNILV-NENNLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYE 786
            |:|||: |.....:|:.||||:..:. ..|..|:.||||||||::||:|||..||.||.||.:.|
Zfish   317 PENILLCNPKRSAIKIVDFGSSCQLG-QRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVE 380

  Fly   787 LYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVM 851
            ::||:.||||.:....:...::|.|..||.::.:.....::||:..:.|:      |.::...:.
Zfish   381 MHTGEPLFSGSNEVDQMNKIVEVLGVPPNHMLDQAPKARKYFDKLSDGLW------TVKKNKDIK 439

  Fly   852 PVVKPS---------RSLQQELIADQNLP------DDQHRKVTQL--KDLLENMFALDPAKRISL 899
            .|:.||         |.|.:.|..:...|      :..|.....|  |||:..|...||..||:.
Zfish   440 KVLYPSASEYKPPATRRLHEILGVETGGPGGRRAGEQGHAPCDYLKFKDLILRMLDYDPKTRITP 504

  Fly   900 NQALVHPFIQE 910
            ..||.|.|.::
Zfish   505 FYALQHNFFKK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	114/336 (34%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	112/328 (34%)
dyrk1b	XP_005158271.1	PKc_DYRK1	175..518	CDD:271128	118/350 (34%)
dyrk1b	XP_005158271.1	S_TKc	186..513	CDD:214567	113/335 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810