DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7028 and dyrk3

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	XP_012815970.1	Gene:	dyrk3 / 493520	XenbaseID:	XB-GENE-1008699	Length:	568	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	136/528 - (25%)
Similarity:	230/528 - (43%)	Gaps:	98/528 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   413 GSLSEGQNKLDKESSDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTG---QESPAPHNSV 474
            |.|:...|||   :..::..|.:..|.||...|              ::|.|   .||..|  .:
Frog    50 GRLTISGNKL---AMKDQQQVKVQQLFEDSGNR--------------RVGAGVTSTESAFP--LL 95

  Fly   475 SYESRSTSQGSSQ-RERPLRTPSPTMPCPNPLISEIPKDREDMDNSTSQKTCSAKEKRNEWDMFA 538
            :.|..|.|.|:|: .:...::...|...|:..:                     |:.:::...:.
Frog    96 TKEKSSDSSGTSKSSDSSAKSSKATYLTPDQAV---------------------KQYKHQLSAYE 139

  Fly   539 DQDVDSNFDVSRKISPNT-----IVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDNRYLVNGYT 598
            .|:: |:|.....:.||.     :|...:       ...:||.:|.|.:...:.:..||.|....
Frog   140 LQEI-SSFSEIYFVGPNAKKRQGVVGGPN-------NGGYDDDQGGYNLVPHDHVAYRYEVLKVI 196

  Fly   599 GQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFF 663
            |:|.|..|.:..|....| ::|:|::||.:..|:....|:.||:.|...|.....:.:.:...|.
Frog   197 GKGSFGQVAKVYDHKLHQ-HLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFT 260

  Fly   664 HKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILV 728
            .:.|:||.||.|:|||.|::|: .|..|..::.||.:...:...|:.|.:..|:|.|:||:|||:
Frog   261 FRNHICMTFELLSMNLYELIKR-NKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILL 324

  Fly   729 NENNLI-LKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKI 792
            .:.... :|:.|||| |......:..|:.|||||:||:|||..|...||.||.||.:.||.||..
Frog   325 KQQGRSGIKVIDFGS-SCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYP 388

  Fly   793 LFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQS------CNFLYHEIDKLTEREKIVVM 851
            ||.|:.....|...|::.|..|.:::.:.: |.::|..|      |.              :..:
Frog   389 LFPGEDEGDQLACMMELLGAPPPKLLEQAK-RAKNFINSKGYPRYCT--------------VTTL 438

  Fly   852 P----VVKPSRSLQQELIADQNLPDDQHRKVTQLK--------DLLENMFALDPAKRISLNQALV 904
            |    |:..|||.:.::.......|    .|..||        |.|:.....||..|::.:|||.
Frog   439 PNGTTVLNGSRSRRGKMRGAPGSKD----WVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALR 499

  Fly   905 HPFIQEKM 912
            |.:|.:::
Frog   500 HQWISKRL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	102/335 (30%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	99/327 (30%)
dyrk3	XP_012815970.1	PKc_DYRK2_3	124..503	CDD:271126	114/429 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910