DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and prpf4ba

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	XP_017207374.1	Gene:	prpf4ba / 393182	ZFINID:	ZDB-GENE-040426-947	Length:	986	Species:	Danio rerio

Alignment Length:	1015	Identity:	420/1015 - (41%)
Similarity:	560/1015 - (55%)	Gaps:	173/1015 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSYDSSNNSETEE-RRAKHKKAKKHKKHKKSSTGKTE---KDRHVHKKQKKAKKRPHRTSESTNE 65
            |..|:.:.:..|: ::.|||...||||||.||..:.:   |.:|.||::.:...|..|...::.|
Zfish    38 KKADNMDFARVEKHKKRKHKHRSKHKKHKHSSPDERDQKHKYKHKHKRKHRDSFRDDRECSTSYE 102

  Fly    66 SDAPENAKLKLSQNCGL-----------SSKFTEIMQKASRNGADFRVGKPLLPTDPSSLVEEIT 119
            ..|....:.:|.....|           :....|:|:.:.::|    :|..|...:..|...|:.
Zfish   103 GAADSPKRFRLDDLAALEDLEKQRAMIQAELDNELMEGSVQSG----MGLILQGYNSDSEDGEVQ 163

  Fly   120 KTIQN-----KMLPVLEVASSSS---ESDVPADAASPIILSIIEDELNLEELMRQKALLQAR--- 173
            :.::|     |.|..|.....:.   :.|...|..   ..|::|.....||:..|....:.|
Zfish   164 EAVRNGEQQRKDLDELVTVKGNGRKLQQDYVNDEQ---FYSVLEGRTMSEEVTVQSHKSEKRESM 225

  Fly   174 --LGAYMSD-----PEAEDKGDLLPHTHSQQLVVHTKSVLKAVTSVPQPQPSKSAAPLATATSK- 230
              ||..:|:     .|.:::........|:.....:||.:|:     :..||.||.....:.::
Zfish   226 TGLGIKISERPSGPSETKERRRSRSTDRSKDRSRRSKSPVKS-----KEVPSSSATSNRKSNTRP 285

  Fly   231 ------HANIKKSTTHNSNESDVIL-------------LDDSSGGQRTPSPT----PEK------ 266
                  |.:..:|:...|.|....|             |.:.|.|:...||:    |::
Zfish   286 EEQAVDHRSSSRSSKSGSKERSTSLPEVDRDKKPVKAPLKEVSSGKENRSPSRKQGPDRLSPTVQ 350

  Fly   267 RRRHASP--LPAAPRS-RCRRDRRSRDRDRSPPRRRASDQQTQVRPRSRNRNMEDLRQEINRDKQ 328
            .|.|.||  ||....: |..|..||...:|||||            |.|:|::|..|:|  .::|
Zfish   351 PRSHRSPERLPVVQNTDRASRQDRSTCHNRSPPR------------RGRSRSVERRRRE--EERQ 401

  Fly   329 RERRDHSRDRDRRGLDRPPPP-----------------------TDMRPGRARERDVRPSRMQRS 370
            |...|..|.||..|..|...|                       :...|.|.|||| |..|.|..
Zfish   402 RLSSDRMRSRDMAGAHREDSPSISSRRRLNHSPLRRRSRSPRRRSSRSPLRHRERD-RMDRRQPV 465

  Fly   371 HSRSKFESDRRRERERQKDRDRGGGRVGARSGTDNGDRDRYKGSLSEGQNKLDKESSDEEVNVNI 435
            .|||: |..|||.:||:                     |.:|||||||. |.::|.|||||..:.
Zfish   466 RSRSQ-ERRRRRSKERE---------------------DMFKGSLSEGM-KAEQEDSDEEVLEDY 507

  Fly   436 DILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVSYESRSTSQGSSQRERPLRTPSPTMP 500
            |: :|:|||.:||.||.:|..:::|.       .|.|..|..|..:..||.|.....|:||
Zfish   508 DV-DEEDEEALIEQRRLQRLAIMQKY-------KPVNEDSNMSGLSDHGSPQSSTHSRSPS---- 560

  Fly   501 CPNPLISEIPKD-----REDMD----------NSTSQKTCSAKEKRNEW-DMFADQD--VDSNFD 547
             |:.::..:..|     :|::|          :..||:...|..|:... |||.:.|  ..:.||
Zfish   561 -PDDILERVAADVKAYEQENLDTFEDNVKAKYSLVSQEKNGANSKKPPAPDMFTESDDMFAAYFD 624

  Fly   548 VSRKISPNTIVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQ 612
            .:|..:...   .|...|||:|.|||.||||||||.||||||.||.|.|||||||||||:|.||.
Zfish   625 SARLRAAGI---GKDFKENPSLRDNWTDAEGYYRVNIGEVLDKRYAVYGYTGQGVFSNVIRARDL 686

  Fly   613 ARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAM 677
            ||....||:|||||||:|.||||:|||.||||||||.:|:||||||:|||:||||||:|||||:|
Zfish   687 ARANQEVAVKIIRNNEMMQKTGLKELEFLKKLNDADADDKFHCLRLFRHFYHKQHLCLVFEPLSM 751

  Fly   678 NLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNLILKLCDFGS 742
            ||||||:||||:|||||||||||:||||||||.||:..|||||||||||||||...|||||||||
Zfish   752 NLREVLRKYGKDVGLHIKAVRSYSQQLFLALKHLKRCNILHADIKPDNILVNEPKTILKLCDFGS 816

  Fly   743 ASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFM 807
            ||.::||:|||||||||||:||||:|..||||||.||.|||:||||||||||.||:||.|||..|
Zfish   817 ASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLNM 881

  Fly   808 DVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQQELIADQNLPD 872
            |:|||:||::||||.|::|||||:.||||.|:||:||||||.||..:.|::.|..:::..|.||:
Zfish   882 DLKGKLPNKMIRKGLFKDQHFDQNLNFLYTEVDKVTEREKITVMSTINPTKDLSMDMVGRQALPE 946

  Fly   873 DQHRKVTQLKDLLENMFALDPAKRISLNQALVHPFIQEKM 912
            ||.:||.||||||:.:..|||||||::||||.||||||::
Zfish   947 DQRKKVGQLKDLLDQILMLDPAKRITINQALQHPFIQERI 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	229/316 (72%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	223/308 (72%)
prpf4ba	XP_017207374.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590007
Domainoid	1	1.000	493	1.000	Domainoid score	I352
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	648	1.000	Inparanoid score	I782
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003592
OrthoInspector	1	1.000	-	-		otm25960
orthoMCL	1	0.900	-	-		OOG6_102293
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.790