DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and Hipk2

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001102092.1	Gene:	Hipk2 / 362342	RGDID:	1309349	Length:	1195	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	151/520 - (29%)
Similarity:	235/520 - (45%)	Gaps:	108/520 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 TGQESPAPHNSVSYESRS--TSQGSSQRERPLRTPSPTMPCPNPLISEIPKDRE----------- 514
            ||..|   |:.|..:|::  .||.:|      .|.|.::|.|||   .:|.::.
  Rat    42 TGYGS---HSKVYSQSKNIPPSQPAS------TTVSTSLPIPNP---SLPYEQTIIFPGSTGHIV 94

  Fly   515 -DMDNSTS------------------------QKTCSAKEKRNEWDMFADQDVDSNFDVSRKISP 554
             ...:|||                        || |..|.|..|.:.      .|:..:..:..|
  Rat    95 VTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQK-CGLKRKSEEIEN------TSSVQIIEEHPP 152

  Fly   555 NTIVQNKHQHENPALT--------DNWDDAEGYYRVRIGEVL---DNRYLVNGYTGQGVFSNVV- 607
              ::||.......|..        ::..::||.|::...|||   .|.|.|..:.|:|.|..||
  Rat   153 --MIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVK 215

  Fly   608 ---RGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLC 669
               ||.::.     |||||::|:....:.|..|:.||.:|:....:| ::.:|.|..|.||.|.|
  Rat   216 CWKRGTNEI-----VAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTC 274

  Fly   670 MVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILV---NEN 731
            :|||.|..||.:.||: .|...|.:|.:|...||:..||..||..|::|||:||:||::   :..
  Rat   275 LVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQ 338

  Fly   732 NLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSG 796
            ...:|:.||||||.:|....:.||.||:||:||||||:|:...||.||.||.|.||:.|..|:.|
  Rat   339 PYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPG 403

  Fly   797 KSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLY----------HEID---KLTEREKI 848
            .|....:::....:|.....::..|....:.|::..:..|          ||.:   |..|..|.
  Rat   404 ASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKY 468

  Fly   849 VV-----MPVVKPSRSLQQELIADQNLPDDQHRKVTQLKDLLENMFALDPAKRISLNQALVHPFI 908
            :.     |..|    ::..:|.....|.:...|:  :..|||:.|..:|..|||:..:.|.|||:
  Rat   469 IFNCLDDMAQV----NMTTDLEGSDMLVEKADRR--EFIDLLKKMLTIDADKRITPIETLNHPFV 527

Fly 909 908
Rat 528 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	113/341 (33%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	111/333 (33%)
Hipk2	NP_001102092.1	STKc_HIPK2	183..537	CDD:271129	119/358 (33%)
Hipk2	NP_001102092.1	S_TKc	199..527	CDD:214567	113/340 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810