DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and Dyrk2

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	151/546 - (27%)
Similarity:	234/546 - (42%)	Gaps:	112/546 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 RD-RYKGS------LSEGQNKLDKESSDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQ 465
            || |..||      |..|..:||..::....|.|......                 |...|.|.
  Fly    53 RDVRLSGSRLDLPQLCNGSRRLDGHNNHVAANENTVTTTS-----------------LNGNGNGN 100

  Fly   466 ESPAPHNS------VSYESRSTSQGSSQRERPLR----------------TPSPTMPCPNPLI-S 507
            .:...:|:      ||..:.::|.|.::|....:                |.|..:.|..|:. |
  Fly   101 GNSNSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPS 165

  Fly   508 EIPKDREDMDNSTSQKTCSAKEKRNEWDMFADQDVDSNFDVSRKISPNTIVQNKHQHEN---PAL 569
            |:.|                        .|.:...|..|: ..|:........:|..:|   ||.
  Fly   166 ELVK------------------------KFRNYLTDLEFE-ELKVYKEVWYFGQHASKNYNKPAP 205

  Fly   570 TDN-----WDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEI 629
            |.|     :||..|.|::...:.:..||.:....|:|.|..|:|..|. :...:||||||||.:.
  Fly   206 TANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDH-KTNTHVAIKIIRNKKR 269

  Fly   630 MHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHI 694
            .....:.||.||.:|.:.|.:...:.:.:..:.:.::|||:.||.:::||.|::||...| |..:
  Fly   270 FLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYN-GFSM 333

  Fly   695 KAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNE-NNLILKLCDFGSASAISDNEITPYLVSR 758
            ..:|.:...:...|:||.|..|:|.|:||:|||:.: .:..:|:.|||| |...|.:|..|:.||
  Fly   334 SLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGS-SCYVDRKIYTYIQSR 397

  Fly   759 FYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQF 823
            ||||||:|||:.|...||.||.||.:.|||||..||.|::..:.|...|:|.|..|..:|...:.
  Fly   398 FYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARR 462

  Fly   824 REQHFDQ----SCNFLYHEIDKLTEREKIVVMPVVKP-SRSLQQELIADQNLPDDQHRKVTQLKD 883
            |...||.    .|      |.....|::       .| |:||...|          |.:.....|
  Fly   463 RRLFFDSRDAPRC------ITNTKGRKR-------SPGSKSLAHIL----------HCQDRYFID 504

  Fly   884 LLENMFALDPAKRISLNQALVHPFIQ 909
            .|:.....|||:|::.::|..|.|:|
  Fly   505 FLQRCLEWDPAERMTPDEAAHHEFLQ 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	108/322 (34%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	106/314 (34%)
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	118/368 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	107/321 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810