DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and Prpf4b

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001011923.1	Gene:	Prpf4b / 291078	RGDID:	1307784	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	1025	Identity:	435/1025 - (42%)
Similarity:	579/1025 - (56%)	Gaps:	168/1025 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SYDSSNNSETEERRAKHKKAKKHKKHKKSSTGKTEKDR---HVHKKQKKAKKRPHRTSESTNESD 67
            |.|.|.|..:..::.|||...||||||.||    |:||   |.||.:.|..||......|..|..
  Rat    33 SEDQSQNKHSRHKKKKHKHRSKHKKHKHSS----EEDRDKKHKHKHKHKKHKRKEVLDASDKEGL 93

  Fly    68 AP-ENAKL---------------------------KLSQNCGL--------SSKFTEIMQKASRN 96
            :| :..||                           |:....||        |.:..||.:|| ||
  Rat    94 SPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKA-RN 157

  Fly    97 G------ADFRVGKPLLPTDPSSLVEEITKTIQNK-------------MLPVLEVASSSSESDVP 142
            |      :....|| |..||..:..::.:|:...:             .:.::...::.|:|...
  Rat   158 GNRSSTRSSSTRGK-LEITDNKNSAKKRSKSRSKERTRHRSDKRKSKGAVEMMREKANRSKSKER 221

  Fly   143 ADAASPIILSIIEDELNLEELMRQKALLQARLGAYMSDPE----AEDKGDLLPHTHSQQLVVHTK 203
            ..:.||...|..:|:....:....:...|.::|...|..:    :|:||.:.....|.  :|:.:
  Rat   222 RKSKSPSKRSKSQDQARKSKSPTLRRRSQEKVGKARSPADEKIKSEEKGKIKDRKKSP--IVNER 284

  Fly   204 SVLKAVTSVPQPQPSKSAAPLATATSKHANIKKSTTHNSNESDVILLD-----------DSSGGQ 257
            |         :.:..||.:|:...........:|....|..|::   |           |:|.|:
  Rat   285 S---------RDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEI---DKEKKPIKSPSKDASSGK 337

  Fly   258 --RTPSPTPEK--RRRHASPLPAAPRSRCRR-------DRRSRDRDRSPPRRRASDQQTQVRPRS 311
              |:||..|.:  :||..||   ..|.:.||       ||||: :.:||.|..:..:      |:
  Rat   338 ENRSPSRRPGRSPKRRSLSP---KQRDKSRRSRSPLLNDRRSK-QSKSPSRTLSPGR------RA 392

  Fly   312 RNRNMEDLRQEINRDKQRERRDHSRD----RDRRGLDRPP----PPTDMR---PGRARERD-VRP 364
            ::|::|..|:|..|.:....|...||    |..|..|..|    .|:..|   |.|.|.|. :|.
  Rat   393 KSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPSRRRSRSPIRRRSRSPLRR 457

  Fly   365 SRMQRSHSRS---KFESDRRRERERQKDRDRGGGRVGARSGTDNGDRDRYKGSLSEGQNKLDKES 426
            ||..|..|||   :..|.|.|.|.|::.|.|||.|..:||..   ..|::|||||||. |:::||
  Rat   458 SRSPRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKV---KEDKFKGSLSEGM-KVEQES 518

  Fly   427 SDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVSYESRSTSQGSSQRERP 491
            |.::...:.|: ||:|||.:||.||.:|:.:::|    .:..|..:::|..|..:|..||.|.|
  Rat   519 SSDDNLEDFDV-EEEDEEAVIEQRRIQRQAIVQK----YKYLAEDSNISVPSEPSSPQSSTRSR- 577

  Fly   492 LRTPSPTMPCPNPLISEIPKD-----REDMDN------------STSQKTCSAKEKRNEWDMFAD 539
                   .|.|:.::..:..|     ||::|.            :..|...|:::|....|||.:
  Rat   578 -------SPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTE 635

  Fly   540 QD--VDSNFDVSRKISPNTIVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDNRYLVNGYTGQGV 602
            .|  ..:.||.:|..:...   .|...|||.|.|||.||||||||.||||||.||.|.|||||||
  Rat   636 SDDMFAAYFDSARLRAAGI---GKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGV 697

  Fly   603 FSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQH 667
            ||||||.||.||....||:|||||||:|.||||:|||.|||||||||:|:||||||:|||:||||
  Rat   698 FSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQH 762

  Fly   668 LCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENN 732
            ||:|||||:||||||||||||:|||||||||||:|||||||||||:..|||||||||||||||:.
  Rat   763 LCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESK 827

  Fly   733 LILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSGK 797
            .|||||||||||.::||:|||||||||||:||||:|..||||||.||.|||:||||||||||.||
  Rat   828 TILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGK 892

  Fly   798 SNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQQ 862
            :||.|||..||:|||:||::||||.|::|||||:.||:|.|:||:|||||:.||..:.|::.|..
  Rat   893 TNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLA 957

  Fly   863 ELIADQNLPDDQHRKVTQLKDLLENMFALDPAKRISLNQALVHPFIQEKM 912
            :||..|.||:||.:||.||||||:.:..||||||||:||||.|.|||||:
  Rat   958 DLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	233/316 (74%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	227/308 (74%)
Prpf4b	NP_001011923.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		29/74 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..535		111/424 (26%)
		PTZ00108	<171..396	CDD:240271	49/249 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..583		9/30 (30%)
		STKc_PRP4	686..1003	CDD:271037	233/316 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348851
Domainoid	1	1.000	487	1.000	Domainoid score	I372
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I765
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003592
OrthoInspector	1	1.000	-	-		oto96929
orthoMCL	1	0.900	-	-		OOG6_102293
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2065
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.790