DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and pom2

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_593081.2	Gene:	pom2 / 2542326	PomBaseID:	SPAC16C9.07	Length:	836	Species:	Schizosaccharomyces pombe

Alignment Length:	862	Identity:	225/862 - (26%)
Similarity:	355/862 - (41%)	Gaps:	152/862 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 DPSSLVEEITKTIQNKMLPVLEVASSSSESDVPADAASPIILSIIEDELNLEELMRQKAL----- 169
            :|..|:.:...:..:|:|  .|:.:|....:.|........:.|.|.....|.|.::|.|
pombe    48 EPVFLLSQRQYSHNSKIL--TELINSVKRPNKPDQNEEKSAVGIEEKSFKDEHLAQKKGLHHFAD 110

  Fly   170 -----LQARLGAY--MSDPEAED---KGDLLPHTHSQQLVVHTKSVLKAVTSVPQPQPSKSAAPL 224
                 |...|...  :.|....|   .|.|.....||    :.:.||:.:.:   |..||....:
pombe   111 LKEIFLNKNLSTLDGLQDASLHDNIQSGKLDNPVISQ----NRRIVLEKLAN---PNSSKEYETI 168

  Fly   225 ATATSKHANIKKSTTHN-SNESDVILLDDSSGGQRTP--------SPT-----PEKRRRH----- 270
            .|..::|...|.|.|.. :.|..:..||::.||...|        |.|     |::.:.|
pombe   169 PTVENRHPLNKLSKTKTLAYEETINQLDETPGGTNYPMNKKKTLSSETNKYEYPQQSKFHECSQF 233

  Fly   271 ASP---LPAAPRSRCRRDRRSRDRDRSPPRRRASDQQTQVRPRSRNRNMEDLRQEINRDKQRERR 332
            |||   :...||:..:..:|:.|..|...|.:.|:....::..|.....:..:....||     .
pombe   234 ASPRSSIVNGPRTLGKNSKRADDTARMASRMKPSNFNNNIQSSSYGHASQSTKLTSQRD-----N 293

  Fly   333 DHSRDRDRRGLDRPP---PPTDMRP-----------GRARERDV---RPSRMQRSHSRSKFESDR 380
            ||.:|     |:..|   .|.:.||           |.....|.   |||. ::.:..|||...
pombe   294 DHQKD-----LNFSPYKSIPLNNRPYSPMSEIVGFSGSTTPLDTYGNRPSG-KKFNKNSKFRPP- 351

  Fly   381 RRERERQKDRDRGGGRVGARSGTDNGDR-DRYKGSLSEGQNKLDKESSDEEVNVNIDILEEDDEE 444
                         |..:.:.|......| .|..||      |:..|..:...|..|.:
pombe   352 -------------GSTISSYSSASTLRRLPRAPGS------KVHAERQNSTFNSGISL------- 390

  Fly   445 RIIELRRKKREELLKKLGTGQESPAPHNSVSYESRSTSQGSSQR--ERPLRTPSPTMPCPNPLIS 507
                  |..|:|:      |..:|...|.:..::....:..|.|  |:.||..:.........::
pombe   391 ------RALRKEM------GNTAPVSSNQLLKDADLVMENLSTRNTEKVLREVNILKRLRESCVA 443

  Fly   508 EIPKDREDMDNS--TSQKTCSAKEKRNEWDMFADQDVDSNFDVSRKISPNTIVQNKHQHENPALT 570
            ...|..:.:|..  .|..|....|.:|...::.     :..:..:|:|.    |......|.||
pombe   444 ITAKSYDTLDERKIRSLTTFEYLEIKNFQKIYF-----TGSENCQKLSK----QIPLDECNEAL- 498

  Fly   571 DNWDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGL 635
              :||..|.|:...|:.|..||.:....|:|.|..|::..|..|||. ||||:|:|.:..|...|
pombe   499 --FDDDNGDYKAIQGDHLLYRYEIIDTVGKGSFGQVLKCIDHKRGQV-VAIKVIKNRQKFHGQTL 560

  Fly   636 RELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSY 700
            .|:.|||:|.:|||.|:.:.:|...||..:.|||:|.|.|..||.:|::: ....||.:..|:|:
pombe   561 VEVGILKRLCEADPADKNNVIRYLSHFDFRGHLCIVTELLGSNLFDVIRE-NNYKGLPLIVVKSF 624

  Fly   701 TQQLFLALKLLKKTGILHADIKPDNILVNEN-NLILKLCDFGSASAISDNEITPYLVSRFYRSPE 764
            ..|...||:||:...|:|.|:||:|:|::.. ...:||.|||| |...:.::..||.|||||:||
pombe   625 ALQGLQALRLLQGQNIIHCDLKPENLLLSHPLKARIKLIDFGS-SCFYNEKVYTYLQSRFYRAPE 688

  Fly   765 IILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFD 829
            ||||:.|...||.||.||.:.||:||..||.|.:..:.|.:.|:|.|..|..:||.....:.:||
pombe   689 IILGLEYGKEIDIWSFGCILAELFTGVPLFPGGNETEQLGYIMEVLGPPPMALIRNSTRSKAYFD 753

  Fly   830 QSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQQELIADQNLPDDQHRKVTQLKDLLENMFALDPA 894
            ..     .:...:|:....:::|   .:|:..|.|          :.|.....|.|......||.
pombe   754 SE-----GKPHPITDSHNRLLVP---STRTFSQLL----------NTKQASFLDFLSKCLKWDPK 800

  Fly   895 KRISLNQALVHPFIQEK 911
            .||:::.||.|.||..|
pombe   801 DRITVDSALQHEFILGK 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	113/317 (36%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	111/309 (36%)
pom2	NP_593081.2	PKc_DYRK	504..814	CDD:271112	117/330 (35%)
pom2	NP_593081.2	S_TKc	518..814	CDD:214567	112/316 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810