DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and pom1

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_592974.1	Gene:	pom1 / 2541889	PomBaseID:	SPAC2F7.03c	Length:	1087	Species:	Schizosaccharomyces pombe

Alignment Length:	1056	Identity:	247/1056 - (23%)
Similarity:	403/1056 - (38%)	Gaps:	219/1056 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKSYDSSNNSETEERRAKHK---KAKKHKKHKKSSTGKTEKDRHVHKKQKKAKKRPHRTSESTNE 65
            |::.|:.....|..|::.:.   |::.....:.|:.|....|  :...::.:......||.|||.
pombe    14 DENTDALFKLHTSNRKSANMFGIKSELLNPSELSAVGSYSND--ICPNRQSSSSTAADTSPSTNA 76

  Fly    66 SDA----PE---------------------NAKLKLSQNCG---LSSKFT-EIMQKAS------- 94
            |:.    ||                     |..:.:..:.|   |.|.|. :..||.|
pombe    77 SNTNISFPEQEHKDELFMNVEPKGVGSSMDNHAITIHHSTGNGLLRSSFDHDYRQKNSPRNSIHR 141

  Fly    95 -------RNGADFRVGKPLLPTDPSSLVEEITKTIQNKMLPVLEVASSSS---ESDVPAD----- 144
                   .|..||...:...|:..::.....|.:|.|..    ...:|.|   .|..|:|
pombe   142 LSNISIGNNPIDFESSQQNNPSSLNTSSHHRTSSISNSK----SFGTSLSYYNRSSKPSDWNQQN 202

  Fly   145 --AASPIILSIIEDELNLEELMRQKALLQARLGAYMSDPEAEDKGDLLPHT------HSQQLVVH 201
              .....::||.:|   :..:..|.::..:...||.:....:..|. ..||      |.:...:.
pombe   203 NGGHLSGVISITQD---VSSVPLQSSVFSSGNHAYHASMAPKRSGS-WRHTNFHSTSHPRAASIG 263

  Fly   202 TKSVLKAVTSVPQPQPSKSAAPLATATSKH----ANIKKSTTHNSNESDVILLDDSSGGQRTPSP 262
            .||.:..|.::|         |....::.|    |||..|.|.:|:||..:....|      |..
pombe   264 NKSGIPPVPTIP---------PNIGHSTDHQHPKANISGSLTKSSSESKNLSTIQS------PLK 313

  Fly   263 TPEKRRRHASPLPAAPRSRCRRDRR-----------------SRDRDRSPPRRRASDQQTQVRPR 310
            |.....:..||......|..:.:..                 ..::..|......:...:||.|.
pombe   314 TSNSFFKELSPHSQITLSNVKNNHSHVGSQTKSHSFATPSVFDNNKPVSSDNHNNTTTSSQVHPD 378

  Fly   311 SRNRNMEDLRQEINRDKQRERRDHSRDRDRRGLDRPPPPTDMRPGRARERDVRPSRMQRS--HSR 373
            |||.:.:...:.::   |:...|..|:.:.:..:     |.....::::...:..|..|.  .||
pombe   379 SRNPDPKAAPKAVS---QKTNVDGHRNHEAKHGN-----TVQNESKSQKSSNKEGRSSRGGFFSR 435

  Fly   374 SKFESDRRRERERQKDRDRGGGRVGA-----------RSGTDNGDR--DRYKGSLSEGQNKLDKE 425
            ..|.....|.::..|.:......|.|           :|...||.:  .|.|..:.:..|.. |.
pombe   436 LSFSRSSSRMKKGSKAKHEDAPDVPAIPHAYIADSSTKSSYRNGKKTPTRTKSRMQQFINWF-KP 499

  Fly   426 SSDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHN-----------SVSYESR 479
            |.:...|.|.|........|:...|.:...|..|........|.|.|           ||||..:
pombe   500 SKERSSNGNSDSASPPPVPRLSITRSQVSREPEKPEEIPSVPPLPSNFKDKGHVPQQRSVSYTPK 564

  Fly   480 STSQGSSQRERPLRTPSPTMPCPNPLISEIPKDREDMD---------------------NSTSQK 523
            .:|..|...:     ||.:....| ::|| |.||:..|                     .|...:
pombe   565 RSSDTSESLQ-----PSLSFASSN-VLSE-PFDRKVADLAMKAINSKRINKLLDDAKVMQSLLDR 622

  Fly   524 TCSAKEKRN------------EWDMFADQDVDSNFDVSRKISPNTIVQNKHQHENPALTDNWDDA 576
            .|.....||            |:    :||..:|:|.........:.:.:...||.:....:||.
pombe   623 ACIITPVRNTEVQLINTAPLTEY----EQDEINNYDNIYFTGLRNVDKRRSADENTSSNFGFDDE 683

  Fly   577 EGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEIL 641
            .|.|:|.:|:.:..||.|..:.|:|.|..|:|..|...|:. ||:|||||.:..|...|.|.:||
pombe   684 RGDYKVVLGDHIAYRYEVVDFLGKGSFGQVLRCIDYETGKL-VALKIIRNKKRFHMQALVETKIL 747

  Fly   642 KKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFL 706
            :|:.:.||.|.:..::...||:.:.|||:..|.|..||.|::|..|.. ||.|..::|.|:||..
pombe   748 QKIREWDPLDEYCMVQYTDHFYFRDHLCVATELLGKNLYELIKSNGFK-GLPIVVIKSITRQLIQ 811

  Fly   707 ALKLLKKTGILHADIKPDNILV-NENNLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIP 770
            .|.||.:..::|.|:||:|||: :.....:|:.|||| |......:..|:.||||||||:|||:.
pombe   812 CLTLLNEKHVIHCDLKPENILLCHPFKSQVKVIDFGS-SCFEGECVYTYIQSRFYRSPEVILGMG 875

  Fly   771 YDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFL 835
            |...||.||.||.|.|:|||..||.|::..:.|...|::.|...:.:|.|...::..||.|
pombe   876 YGTPIDVWSLGCIIAEMYTGFPLFPGENEQEQLACIMEIFGPPDHSLIDKCSRKKVFFDSS---- 936

  Fly   836 YHEIDKLTEREKIVVMPVVKPSRSLQQELIADQNLPDDQHRKVTQLKDL-----LENMFALDPAK 895
                              .||...:..:.::.:......| :|.|.||:     :.:....||.:
pombe   937 ------------------GKPRPFVSSKGVSRRPFSKSLH-QVLQCKDVSFLSFISDCLKWDPDE 982

  Fly   896 RISLNQALVHPFIQEK 911
            |::..||..|.|:..|
pombe   983 RMTPQQAAQHDFLTGK 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	109/322 (34%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	106/314 (34%)
pom1	NP_592974.1	PKc_DYRK	685..995	CDD:271112	113/335 (34%)
pom1	NP_592974.1	S_TKc	699..995	CDD:214567	108/321 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810