DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and mik1

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_595093.1	Gene:	mik1 / 2540885	PomBaseID:	SPBC660.14	Length:	581	Species:	Schizosaccharomyces pombe

Alignment Length:	577	Identity:	118/577 - (20%)
Similarity:	197/577 - (34%)	Gaps:	183/577 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 YKGSLSEGQNKLDKESSDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVS 475
            :|.|..:|.:|....||..:::..|     .|....|:|:||:   .:..|.||..|.....|:
pombe    89 FKNSDLDGCSKPFAFSSGLKLSKKI-----VDASTPIDLKRKR---AVTSLSTGLLSKREKWSL- 144

  Fly   476 YESRSTSQGSSQRERP--------LRTP-SPTMPCPNPL-----------ISEIPKDREDMDNST 520
            :|...|:..|.|...|        |:.| ||..|..:.|           .|.:.....|..:.|
pombe   145 WEGNLTNPRSEQPHTPCKKGTKIKLKPPQSPLSPTTSLLARKCKHIDLDTFSRLDHPNSDSSDET 209

  Fly   521 -------------------------SQKTCSAKEKRNEWDMFADQDVDSNFDVSRKISPNTIVQN 560
                                     ||....:....|.||   ::||.|:...: ..||..:..|
pombe   210 FEMEELPSLSYGSEDLLEFCETPCKSQPIFLSSSHVNNWD---EKDVPSSLSWT-PTSPIFLNIN 270

  Fly   561 KHQHENPALTDNWDDAEGY---YRVRIGEV-----LDNRYL-----VNGYTGQGVFSNVVRGRDQ 612
            .        .|::::.|.:   .|:|..:|     .|..::     :|..|
pombe   271 S--------ADDYEEEEDWTSDLRIRFQQVKPIHESDFSFVYHVSSINPPT-------------- 313

  Fly   613 ARGQANVAIKIIRNNEIMHKTG----LRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFE 673
               :....:|:::.|.... ||    |:|:.||::|                      ..|
pombe   314 ---ETVYVVKMLKKNAAKF-TGKERHLQEVSILQRL----------------------QAC---- 348

  Fly   674 PLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFL-----------------------ALKLLKKTG 715
            |..:||..|. .|..|:.|.:....:....|||                       ||..:....
pombe   349 PFVVNLVNVW-SYNDNIFLQLDYCENGDLSLFLSELGLLQVMDPFRVWKMLFQLTQALNFIHLLE 412

  Fly   716 ILHADIKPDNILVNENNLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSA 780
            .:|.|:||.|:|:..:. .|||.|||.|:::..:.:......|.|.:|||:....|....|.:|.
pombe   413 FVHLDVKPSNVLITRDG-NLKLGDFGLATSLPVSSMVDLEGDRVYIAPEILASHNYGKPADVYSL 476

  Fly   781 GCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTER 845
            |.::.|..|..:|                    |...:...:.|...:....|..    |.|..:
pombe   477 GLSMIEAATNVVL--------------------PENGVEWQRLRSGDYSNLPNLK----DLLLSK 517

  Fly   846 EKIVVMPVVKPSRSLQQELIADQNLPDDQHRKVTQLKDLL---ENMFALDPAKRISL 899
            ||:.:.. |:.:.|||. |:.....|....|..||  |||   |.:|..:.:::.::
pombe   518 EKVQINK-VRCAESLQC-LLQRMTHPYVDCRPTTQ--DLLAMPEMIFISEHSQKAAI 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	70/344 (20%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	68/331 (21%)
mik1	NP_595093.1	PTKc_Wee1_fungi	288..556	CDD:270954	71/341 (21%)
mik1	NP_595093.1	S_TKc	300..556	CDD:214567	68/329 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960