Protein Alignment CG7028 and DYRK1A

DIOPT Version :9

• Sequence 1: NP_001286884.1
• Gene: CG7028 / 38032
• FlyBaseID: FBgn0027587
• Length: 912
• Species: Drosophila melanogaster
• Sequence 2: NP_001387.2
• Gene: DYRK1A / 1859
• HGNCID: 3091
• Length: 763
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 144/479 - (30%)
• Similarity: 219/479 - (45%)
• Gaps: 70/479 - (14%)

  Fly   470 PHN---------SVSYESRSTSQGSSQRERPLRTPSPTMPCPNPLISEIPKDREDMDNSTSQK-- 523
            ||:         ::|.:..|....|.|.::||  .:..||....|...:|:...|...:..:|
Human    35 PHSHQYSDRRQPNISDQQVSALSYSDQIQQPL--TNQVMPDIVMLQRRMPQTFRDPATAPLRKLS 97

  Fly   524 ------------TCSAKEKRNEWDMFADQDVDSNFDVSRKISPNTIVQNKHQHENPALTDNWDDA 576
                        ...||:||....   .|..||:                |:.|.....|.:||.
Human    98 VDLIKTYKHINEVYYAKKKRRHQQ---GQGDDSS----------------HKKERKVYNDGYDDD 143

  Fly   577 EGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEIL 641
            ...|.|:.||...:||.::...|:|.|..||:..|:.. |..||||||:|.:........|:.:|
Human   144 NYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVE-QEWVAIKIIKNKKAFLNQAQIEVRLL 207

  Fly   642 KKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFL 706
            :.:|..|.|.:::.:.|.|||..:.|||:|||.|:.||.::|:..... |:.:...|.:.||:..
Human   208 ELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFR-GVSLNLTRKFAQQMCT 271

  Fly   707 ALKLL--KKTGILHADIKPDNILV-NENNLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILG 768
            ||..|  .:..|:|.|:||:|||: |.....:|:.||||:..:. ..|..|:.||||||||::||
Human   272 ALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLG-QRIYQYIQSRFYRSPEVLLG 335

  Fly   769 IPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRII----RKGQFREQHFD 829
            :|||..||.||.||.:.|::||:.||||.:....:...::|.|..|..|:    :..:|.|:..|
Human   336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPD 400

  Fly   830 QSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQQELIADQNLP------DDQHRKVTQL--KDLLE 886
            .:.|.      |.|:..|....|  ..:|.|...|..:...|      :..|.....|  |||:.
Human   401 GTWNL------KKTKDGKREYKP--PGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLIL 457

  Fly   887 NMFALDPAKRISLNQALVHPFIQE 910
            .|...||..||....||.|.|.::
Human   458 RMLDYDPKTRIQPYYALQHSFFKK 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	113/331 (34%)
		S_TKc	599..908	CDD:214567	111/323 (34%)
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..57		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		7/39 (18%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		6/35 (17%)
		PKc_DYRK1	148..484	CDD:271128	117/345 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		7/35 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..679
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..763

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810