DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and prpf-4

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001250391.1	Gene:	prpf-4 / 172443	WormBaseID:	WBGene00004186	Length:	775	Species:	Caenorhabditis elegans

Alignment Length:	1003	Identity:	345/1003 - (34%)
Similarity:	454/1003 - (45%)	Gaps:	350/1003 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADDKSYDSS------NNSET--EERRAKHKKAKKHKKHKKSSTGKTEKDRHVHKKQKKAKKRPHR 58
            :|:|:.||.      .:||.  ::::.||||.|||||.||            |||:||.|    |
Worm    20 SDEKASDSEVEKRQRTDSERSGKDKKKKHKKEKKHKKDKK------------HKKEKKHK----R 68

  Fly    59 TSESTNESDAPENAKLKLSQNCGLSSKFTEIMQKASRNGADFRVGKPLLPTDPSSLVEEITKTIQ 123
            ..|...|:|.|                                      |....:|.|..||..:
Worm    69 EKEVEMENDGP--------------------------------------PAKKRTLEEVDTKKDE 95

  Fly   124 NKMLPVLEVASSSSESDVPADAASPIILSIIEDELNLEELMRQKALLQARLGAYMSDPEAEDKGD 188
            :|.    :.|..||.::              ||||.
Worm    96 SKK----KEAKESSRNN--------------EDELR----------------------------- 113

  Fly   189 LLPHTHSQQLVVHTKSVLKAVTSVPQPQPSKSAAPLATATSKHANIKKSTTHNSNESDVILLDDS 253
                                  :.|:.:.||||
Worm   114 ----------------------NPPRRERSKSA-------------------------------- 124

  Fly   254 SGGQRTPSPTPEKRRRHASPLPAAPRSRCRRDRRSRDRDRSPPRRRASDQQTQVRPRSRNRNMED 318
                       |:|.|..         |.|||...|||..|..||..            .|..||
Worm   125 -----------ERRDREL---------RERRDAERRDRSLSKERRLI------------QRKRED 157

  Fly   319 LRQEINRDKQRERRDHSRDRDRRGLDRPPPPTDMRPGRARERD-VRPSRMQRSHSRSKFESDRRR 382
            .|::....:...|||.:.:|.|...||            |:|| .|..|.:||..|.: :|||:|
Worm   158 NRRDPRAHEGNRRRDRTPERFRNNRDR------------RDRDGRREDRHRRSPDRRR-DSDRKR 209

  Fly   383 ERERQKDRDRGGGRVGARSGTDNGDRDRYKGSLSEGQNKLDKESSDEEVNVNIDILEEDDEERII 447
            |..::||                                   ||.|.|.|::.|   .|||::.|
Worm   210 EDGKRKD-----------------------------------ESKDVEWNLDSD---SDDEQKKI 236

  Fly   448 ELRRKKREELLKKLGTGQESPAPHNSVSYES---------------------------------- 478
            |..||:|.:::||:....|...|.:|.:..|
Worm   237 EAARKRRIQIIKKIEGHTEENTPRDSSTPRSDTIGDKKTDESEDSSSDSEDDEDDRKLAEAKDLI 301

  Fly   479 RSTSQGSSQ---RERPLRTPSPTMPCPNPLISEIP------------------------------ 510
            :||..||.|   ...|:...|.. ..|....|.:.
Worm   302 KSTRFGSEQGSGASTPVSIQSDN-DTPTDFFSGLRDKMVHMKDADEHNVDEVLQRGKDEEYREDW 365

  Fly   511 ----KDREDMDNSTSQKTC-------SAKEKRNE-----WDMFAD-----QDVDSNFDVSRKISP 554
                |::|..:....:|..       :||:|:.|     :|||||     ||
Worm   366 HTQLKEQEKREEEEKKKKLEAEAAAEAAKKKKQEEDDTGFDMFADNEELPQD------------- 417

  Fly   555 NTIVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANV 619
            :|.:.......:..|.|||||.||||||||||:||.||.|.|:||.|||.||.|..||.:|. .|
Worm   418 STTIDGHSGAVHDTLKDNWDDVEGYYRVRIGELLDTRYRVVGFTGAGVFGNVCRCNDQTKGN-TV 481

  Fly   620 AIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLK 684
            |:|||||||:|:||||||||:|:|||:||.||::|||||:|.|.|..|||:|||.|:|||||:||
Worm   482 AVKIIRNNEVMYKTGLRELEVLRKLNEADKEDKYHCLRLFRTFKHHNHLCLVFENLSMNLRELLK 546

  Fly   685 KYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNLILKLCDFGSASAISDN 749
            |||:..|||:||||||.|||.|||:||||...:|||||||||||||:.|.|||||||||..:::.
Worm   547 KYGQKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKLTLKLCDFGSAGRVNEQ 611

  Fly   750 EITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIP 814
            |:.|||||||||:|||:||:.:||.||.||...|:||:|||||:|.|::||.|||.|.|||||.|
Worm   612 ELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYEVYTGKIMFPGRTNNHMLKLFTDVKGKYP 676

  Fly   815 NRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQQELIADQNLPDDQHRKVT 879
            |:::||.||::.|||.:||.||.|:||:|||.||.|:..:||:|.|:.||||.|.|..||..::.
Worm   677 NKLVRKSQFKDTHFDVNCNLLYQEVDKVTERNKITVLANLKPTRDLESELIAGQRLSRDQMDQIQ 741

  Fly   880 QLKDLLENMFALDPAKRISLNQALVHPF 907
            ..:.||:.|..|||:||.:.|:||.|||
Worm   742 AFRTLLDGMLILDPSKRTTCNEALKHPF 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	198/317 (62%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	193/309 (62%)
prpf-4	NP_001250391.1	STKc_PRP4	454..770	CDD:271037	198/317 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163614
Domainoid	1	1.000	412	1.000	Domainoid score	I346
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	484	1.000	Inparanoid score	I797
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003592
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102293
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R996
SonicParanoid	1	1.000	-	-		X2065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.010