DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7028 and Dyrk4

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	XP_011239406.1	Gene:	Dyrk4 / 101320	MGIID:	1330292	Length:	685	Species:	Mus musculus

Alignment Length:	565	Identity:	145/565 - (25%)
Similarity:	224/565 - (39%)	Gaps:	147/565 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 KLGTGQESP-APHNSVSYESRSTSQGSSQRERPLRT---------------PSPTMPCPNPLISE 508
            |:..|...| ||.:|.|..|..|::.   |:|.|.|               ..||:|....::..
Mouse    39 KIIKGSSPPLAPRDSGSRTSMDTNKA---RKRSLTTFPILKARKKQSFTSVKGPTLPPEIYMVES 100

  Fly   509 IP---------KDREDMDNSTSQKTCS--------AKEKRN-------------------EWDMF 537
            .|         |:::...|...||..|        .|.|||                   :.:..
Mouse   101 KPLGHLQKPSSKNKKLRVNRCPQKIPSNTAFPFVDTKGKRNTVNFPQIGNKVPSKGPMQYQENQI 165

  Fly   538 ADQDVDSN-------FDVSRK---ISPNTIVQNKH---------------------QHENPALTD 571
            .:|.:.|.       |:::.|   ..|:..:|.||                     |.|....::
Mouse   166 HNQVLSSELKTSEIPFNINTKAQDTKPHPELQKKHKVPLTVAEALKFFKNQLSPYEQSEILGYSE 230

  Fly   572 NW---------------------DDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARG 615
            .|                     ||..|.|...:.:.:..||.|....|:|.|..|.:..|....
Mouse   231 LWFLGLEAKKLNVVPEKFSKTSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNN 295

  Fly   616 QANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLR 680
            :. ||:|||||.:..|...|.||:||:.|...|.::..:.:.:...|:.:.|||:.||.|.:||.
Mouse   296 EL-VALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLY 359

  Fly   681 EVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNI-LVNENNLILKLCDFGSAS 744
            |::|....: |.::..||.:|..:...|.:|....|:|.|:||:|| |.....:.:|:.|||| |
Mouse   360 ELMKNNSFH-GFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGS-S 422

  Fly   745 AISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDV 809
            .....::..|:.||||||||:|||.||:..||.||.||.:.|||||..||.|::..:.|...|:|
Mouse   423 CYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEV 487

  Fly   810 KGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQQEL---IADQNLP 871
            .|..|....:....|:..||                           |:.|.:.:   ...:..|
Mouse   488 LGLPPAHFTQTASRRQVFFD---------------------------SKGLPKNINNNRGGKRYP 525

  Fly   872 DDQHRKV------TQLKDLLENMFALDPAKRISLNQALVHPFIQE 910
            |.:...:      :...|.|......:|:.|::..|||.|.:|.|
Mouse   526 DSKDLTMVVKTYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWIHE 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	102/326 (31%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	99/318 (31%)
Dyrk4	XP_011239406.1	PKc_DYRK4	228..568	CDD:271127	107/369 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810