DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7028 and dyrk3

DIOPT Version :9

Sequence 1:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001108400.1	Gene:	dyrk3 / 100141364	ZFINID:	ZDB-GENE-080219-31	Length:	581	Species:	Danio rerio

Alignment Length:	549	Identity:	143/549 - (26%)
Similarity:	234/549 - (42%)	Gaps:	77/549 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 GGGRVGARSGTD---NGDRDRYKGSLSEGQNKLDKES-------SDEEV----NVNIDILEEDDE 443
            |.|...:...||   |.|.| ..|....|...|.|.:       .|.:.    .:.:..:.||..
Zfish    17 GDGLYDSYMRTDHIVNQDAD-VNGQSPSGLPPLPKHTGVIKPTMKDHQAIRGGQMKVKYVYEDSY 80

  Fly   444 ERIIELRRKKREELLKKLGTGQESPAPHNSVSYE----SRSTSQGSSQRERPLRTPSPTMPCPNP 504
            .|       |...:.:..||.|....|..::|.|    |.|:.:.|....:..:..||..|
Zfish    81 NR-------KLNGVSQHNGTSQVPAKPPPAISKERSVDSNSSVKSSESSTKVTKLGSPMTP---- 134

  Fly   505 LISEIPKDREDMDNSTSQKTCSAKEKRNEWDMFADQDVDSNFDVSRKISPNTIVQNKHQHENPAL 569
                               ..:.|:.|.:......|:: .|:.....:.||.    |.:......
Zfish   135 -------------------EQALKQHRQQMTTLEQQEI-HNYSEIYFLGPNA----KKRQAVAGG 175

  Fly   570 TDN--WDDAEGYYRVRIGEVLDNRYLVNGYTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHK 632
            |:|  :||.:|.|.....:.|..||......|:|.|..|.:..|. :.|.:||:||:||.:..|:
Zfish   176 TNNSGYDDDQGGYIHVPHDHLAYRYEFLKVIGKGSFGQVAKVYDH-KLQQHVALKIVRNEKRFHR 239

  Fly   633 TGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAV 697
            ....|:.||:.|...|.....:.:.:..:|..:.|:||.||.|:|||.|::|: .|..|..:..|
Zfish   240 QAAEEIRILEHLKKQDKTGSMNVVHMLENFTFRNHICMTFELLSMNLYELIKR-NKFQGFSLPLV 303

  Fly   698 RSYTQQLFLALKLLKKTGILHADIKPDNILVNENNLI-LKLCDFGSASAISDNEITPYLVSRFYR 761
            |.:...:...|:.|.:..|:|.|:||:|||:.:.... :|:.|||| |......:..|:.|||||
Zfish   304 RKFAHSILQCLEALHRHKIIHCDLKPENILLKQQGRSGIKVIDFGS-SCFDHQRVYTYIQSRFYR 367

  Fly   762 SPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQ 826
            :||:|||..|...||.||.||.:.||.||..||.|:.....|...|::.|..|::::.:.:..:.
Zfish   368 APEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPSKLLEQAKRAKN 432

  Fly   827 HFDQSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQQELIADQNLPDDQHRKVTQLK--------D 883
            ......:..|..:..|:..     ..|:..|||.:.::   :..|..:... |.||        |
Zfish   433 FISSKGHPRYCTVSTLSNG-----TIVLNGSRSRRGKM---RGAPGSKEWG-TALKGCEDATFID 488

  Fly   884 LLENMFALDPAKRISLNQALVHPFIQEKM 912
            .|:.....||:.|::..|||.||::.:::
Zfish   489 FLKKCLDWDPSTRMTPVQALRHPWLYKRL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	101/325 (31%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	99/317 (31%)
dyrk3	NP_001108400.1	PKc_DYRK2_3	134..513	CDD:271126	116/418 (28%)
dyrk3	NP_001108400.1	S_TKc	200..513	CDD:214567	100/324 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810