DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NitFhit and NIT1

DIOPT Version :9

Sequence 1:	NP_525122.1	Gene:	NitFhit / 38029	FlyBaseID:	FBgn0024945	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_012102.1	Gene:	NIT1 / 854642	SGDID:	S000001426	Length:	199	Species:	Saccharomyces cerevisiae

Alignment Length:	206	Identity:	44/206 - (21%)
Similarity:	78/206 - (37%)	Gaps:	50/206 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ATIAVGQM-RSTSDKAANLSQVIELVDRAKSQNACMLFLPECC-----------DFVG----ESR 81
            |.:.:|.. .||.|   .|.:::......|...|.::.:||..           .::|    |.|
Yeast     7 AALQIGSCPGSTKD---TLKKILSYEKEIKESGAKLVVIPEATLGGYPKGSNFGVYLGYRLQEGR 68

  Fly    82 -------TQTIELSEGLDGELMAQYRELAKCNKIWISLGGVHERNDQKIFNAHVLLNEKGELAAV 139
                   .:.||:..|.....::|...|:|.....:.:|.: ||:...::...|.::.|......
Yeast    69 EEYAKYLAEAIEIGNGEKYPEISQLCALSKATDASLCVGCI-ERDGTTLYCTMVYIDPKDGYVGK 132

  Fly   140 YRKLHMFDVTTKEVRL---RESDTVTPGYCLERPVSTPVGQIGLQICYD-----LRFAEPAVLLR 196
            :|||    :.|...||   :...:..|      .|.|..|:||..||::     ||:|     :.
Yeast   133 HRKL----MPTAGERLIWGQGDGSTLP------VVDTAAGKIGGAICWENMMPLLRYA-----MY 182

  Fly   197 KLGANLLTYPS 207
            |.|..:...|:
Yeast   183 KKGVEIWCAPT 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NitFhit	NP_525122.1	nit	34..296	CDD:143596	43/205 (21%)
NitFhit	NP_525122.1	FHIT	317..436	CDD:238606
NIT1	NP_012102.1	nitrilase	4..>198	CDD:416265	44/206 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810