DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NitFhit and NIT2

DIOPT Version :9

Sequence 1:	NP_525122.1	Gene:	NitFhit / 38029	FlyBaseID:	FBgn0024945	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_064587.1	Gene:	NIT2 / 56954	HGNCID:	29878	Length:	276	Species:	Homo sapiens

Alignment Length:	272	Identity:	95/272 - (34%)
Similarity:	154/272 - (56%)	Gaps:	4/272 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SATIAVGQMRSTSDKAANLSQVIELVDRAKSQNACMLFLPECCDFVGESRTQTIELSEGLDGELM 96
            |..:|:.|::.:|.|:.|:::....:..|.:|.|.::.||||.:....:: ...|.:|.:.||..
Human     3 SFRLALIQLQISSIKSDNVTRACSFIREAATQGAKIVSLPECFNSPYGAK-YFPEYAEKIPGEST 66

  Fly    97 AQYRELAKCNKIWISLGGVHERNDQKIFNAHVLLNEKGELAAVYRKLHMFDVTTK-EVRLRESDT 160
            .:..|:||...|::..|.:.|.:..|::|...:....|.|.|.|||:|:||:... ::..:||.|
Human    67 QKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDVPGKITFQESKT 131

  Fly   161 VTPGYCLERPVSTPVGQIGLQICYDLRFAEPAVLLRKLGANLLTYPSAFTYATGKAHWEILLRAR 225
            ::||.... ...||..::||.||||:||||.|.:..:.|..||.||.||...||.||||:|.|:|
Human   132 LSPGDSFS-TFDTPYCRVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRSR 195

  Fly   226 AIETQCFVVAAAQIGWHNQKRQSWGHSMIVSPWGNVLADCSEQELDIGTAEVDLSVLQSLYQTMP 290
            |::.|.:|..|:..........:||||.:|:|||.|||....:|. |..:::||..|..:.|.:|
Human   196 AVDNQVYVATASPARDDKASYVAWGHSTVVNPWGEVLAKAGTEEA-IVYSDIDLKKLAEIRQQIP 259

  Fly   291 CFEHRRNDIYAL 302
            .|..:|:|:||:
Human   260 VFRQKRSDLYAV 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NitFhit	NP_525122.1	nit	34..296	CDD:143596	90/262 (34%)
NitFhit	NP_525122.1	FHIT	317..436	CDD:238606
NIT2	NP_064587.1	nit	5..265	CDD:143596	90/262 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154369at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820