DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NitFhit and nit1

DIOPT Version :9

Sequence 1:	NP_525122.1	Gene:	NitFhit / 38029	FlyBaseID:	FBgn0024945	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001004638.1	Gene:	nit1 / 447900	ZFINID:	ZDB-GENE-040912-65	Length:	316	Species:	Danio rerio

Alignment Length:	294	Identity:	143/294 - (48%)
Similarity:	199/294 - (67%)	Gaps:	13/294 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QKRKDQSATI-AVGQMRSTSDKAANLSQVIELVDRAKSQNACMLFLPECCDFVGESRTQTIELSE 89
            |.|...|..: ||.||.:|.||.||......||::||...|.|:||||..|::|.||.:|::|||
Zfish    26 QSRMSSSVPVAAVCQMTATPDKEANFRTCTRLVEQAKVGGASMVFLPEGFDYIGSSREETLQLSE 90

  Fly    90 GLDGELMAQYRELAKCNKIWISLGGVHE-----RNDQKIFNAHVLLNEKGELAAVYRKLHMFDV- 148
            .||||.:::|..||:...:|:||||.||     :.|::|:|:|:::|.:||:.:||||.|:|||
Zfish    91 SLDGETISRYTHLARKLDVWLSLGGFHEQGHDWKTDRRIYNSHIIINGQGEIVSVYRKTHLFDVE 155

  Fly   149 -TTKEVRLRESDTVTPGYCLERPVSTPVGQIGLQICYDLRFAEPAVLLRKLGANLLTYPSAFTYA 212
             ::|.|.|:||....||..|..||.||:|::||.:||||||.|.:..|::.||.:||||||||.|
Zfish   156 LSSKGVSLKESAFTIPGPRLVPPVQTPIGKVGLGVCYDLRFPELSAALQRHGAEILTYPSAFTVA 220

  Fly   213 TGKAHWEILLRARAIETQCFVVAAAQIGWHNQKRQSWGHSMIVSPWGNVLADCSEQELDIGTAEV 277
            ||.||||:||||||:||||||:||||:|.|:.||.|:||::.|.|||.||.||...:..:..|.:
Zfish   221 TGTAHWEVLLRARAVETQCFVLAAAQVGSHHSKRVSYGHALAVDPWGEVLGDCGGTQEGVTLAHI 285

  Fly   278 DLSVLQSLYQTMPCFEHRR-NDIYALTAYNLRSK 310
            :|..|:.:.:.||..:||| .|.|.    :|.||
Zfish   286 NLQKLRDIRRDMPVLQHRRQTDFYC----SLDSK 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NitFhit	NP_525122.1	nit	34..296	CDD:143596	133/269 (49%)
NitFhit	NP_525122.1	FHIT	317..436	CDD:238606
nit1	NP_001004638.1	nit	36..304	CDD:143596	133/267 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594436
Domainoid	1	1.000	267	1.000	Domainoid score	I1837
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154369at2759
OrthoFinder	1	1.000	-	-		FOG0004252
OrthoInspector	1	1.000	-	-		oto40015
orthoMCL	1	0.900	-	-		OOG6_103694
Panther	1	1.100	-	-	LDO	PTHR23088
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3511
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760