DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rno and KDM4A

DIOPT Version :9

Sequence 1:NP_001246528.1 Gene:rno / 38027 FlyBaseID:FBgn0035106 Length:3241 Species:Drosophila melanogaster
Sequence 2:NP_055478.2 Gene:KDM4A / 9682 HGNCID:22978 Length:1064 Species:Homo sapiens


Alignment Length:688 Identity:150/688 - (21%)
Similarity:231/688 - (33%) Gaps:247/688 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 GQGRAAAGATSTSKSKSTKLAKSASKCKSQGASSSSSWQARSVADIKMSSIYNRSSTEAPAELYR 151
            |.||...|...|.|             |...|.|.|..:...|||..|.|:.....::.     |
Human   550 GDGRVTVGEPCTRK-------------KGSAARSFSERELAEVADEYMFSLEENKKSKG-----R 596

  Fly   152 KDLISAMKLPDSEPLANYEYLIVTDPWKQEWEKGVQVPVNPDSLPEPCVYVLPEPVVSPAHDFKL 216
            :..:|  |||...||.                  :|..|:.|...|                   
Human   597 RQPLS--KLPRHHPLV------------------LQECVSDDETSE------------------- 622

  Fly   217 PKNRYLRITKDEHYSPDLHYLTNVVALAENTCAYDIDPIDEAWL---------RLYNSDRAQ--- 269
                  ::|.:|.              ||.|.|: ..|:.:.|.         :.:|...||   
Human   623 ------QLTPEEE--------------AEETEAW-AKPLSQLWQNRPPNFEAEKEFNETMAQQAP 666

  Fly   270 ----------------------CGAFPINATQFERVIEELEVRCWEQIQVILKLEEGLGIEFDEN 312
                                  ||.....|.|.:|....:...|:          ...|...|.|
Human   667 HCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCF----------TSTGCSTDIN 721

  Fly   313 VICDVCRSPDSEE--ANEMVFCDNCNICVHQACYGI-TAIPSGQWLCRTCSM-GIKPDCVLCPNK 373
            :     .:|..||  .:.:|.|..|::.||.:|||: .|..|..|:|..||. .::.||.||..:
Human   722 L-----STPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLR 781

  Fly   374 GGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLCRKR----VGSC 434
            |||:: ..:...|.|||||:.|.|.....:....|: .:|.||..|:.|.|:.|:||    .|.|
Human   782 GGALQ-RANDDRWVHVSCAVAILEARFVNIAERSPV-DVSKIPLPRFKLKCIFCKKRRKRTAGCC 844

  Fly   435 IQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSY--CQKHSMSKGKKENAGSHGGGS 497
            :|||...|.||:||:||...|:.|:        .|......:  |.:|     |..|.....|..
Human   845 VQCSHGRCPTAFHVSCAQAAGVMMQ--------PDDWPFVVFITCFRH-----KIPNLERAKGAL 896

  Fly   498 ASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNHRKTELTSEERNQARAQRLQEVEAE 562
            .|:.:..:..:::.:|                    |........||:|...:            
Human   897 QSITAGQKVISKHKNG--------------------RFYQCEVVRLTTETFYE------------ 929

  Fly   563 FDKHVNFND--ISCHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDV-------------E 612
                |||:|  .|.:|:..|   ||           |:...:..||...:|             :
Human   930 ----VNFDDGSFSDNLYPED---IV-----------SQDCLQFGPPAEGEVVQVRWTDGQVYGAK 976

  Fly   613 MIAR---KQEQQDMENHKLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFYKQLGVLDEM 674
            .:|.   :..|.:.|:...:|..|.|   |..|...:.:|.|              .:|.|..:|
Human   977 FVASHPIQMYQVEFEDGSQLVVKRDD---VYTLDEELPKRVK--------------SRLSVASDM 1024

  Fly   675 RL-----EKQQTKQEQQQPVMDLNAVIYAND--GPTLY 705
            |.     ||:..:::::|.|::..   |..|  .|.||
Human  1025 RFNEIFTEKEVKQEKKRQRVINSR---YREDYIEPALY 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rnoNP_001246528.1 COG5141 250..>664 CDD:227470 105/475 (22%)
EPL1 <250..288 CDD:287484 10/71 (14%)
PHD_JADE 314..359 CDD:277048 15/47 (32%)
ePHD_RNO 367..480 CDD:277177 40/118 (34%)
TFIIA 2138..>2295 CDD:281188
KDM4ANP_055478.2 JmjN 13..55 CDD:128818
JmjC 175..291 CDD:202224
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..384
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..537
Interaction with NCOR1. /evidence=ECO:0000269|PubMed:16024779 597..638 16/100 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..641 9/64 (14%)
PHD_JMJD2A 667..766 CDD:277050 24/113 (21%)
ePHD_JMJD2A 775..884 CDD:277183 40/118 (34%)
TUDOR 897..953 CDD:197660 16/105 (15%)
TUDOR 955..1010 CDD:197660 11/57 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5141
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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