DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rno and MLLT10

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	XP_024303947.1	Gene:	MLLT10 / 8028	HGNCID:	16063	Length:	1102	Species:	Homo sapiens

Alignment Length:	1564	Identity:	318/1564 - (20%)
Similarity:	517/1564 - (33%)	Gaps:	560/1564 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 CDVCRSPDSEEANEMVFCD--NCNICVHQACYGITAIPSGQWLCRTC---SMGIKPDCVLCPNKG 374
            |.||........|.:|:||  .|::.||||||||..:|:|.|.||.|   ....:..|.|||:|.
Human    25 CCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKD 89

  Fly   375 GAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLC-------RKRVG 432
            ||:|...:| .||||.|||:||||....|..||||. :.|:|..|::..|.:|       :...|
Human    90 GALKRTDNG-GWAHVVCALYIPEVQFANVSTMEPIV-LQSVPHDRYNKTCYICDEQGRESKAATG 152

  Fly   433 SCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSYCQKHSMSKGKKENAGSHGGGS 497
            :|:.|:...|:.|:|||||...||...   ||||..|.|:...||:.| .||.||...||:....
Human   153 ACMTCNKHGCRQAFHVTCAQFAGLLCE---EEGNGADNVQYCGYCKYH-FSKLKKSKRGSNRSYD 213

  Fly   498 ASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNHRKTELTSEERNQARAQRLQEVEAE 562
            .|::.:...:                          :.|:|.|.:...:|:
Human   214 QSLSDSSSHS--------------------------QDKHHEKEKKKYKEK-------------- 238

  Fly   563 FDKHVNFNDISCHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARKQEQQDMENHK 627
             |||                             |.:|.::..|..:
Human   239 -DKH-----------------------------KQKHKKQPEPSPA------------------- 254

  Fly   628 LVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFYKQLGVLDEMRLEKQQTKQEQQQPVMDL 692
            ||..|....|:.    |..:....:|.||                 .|||....:
Human   255 LVPSLTVTTEKT----YTSTSNNSISGSL-----------------KRLEDTTAR---------- 288

  Fly   693 NAVIYANDGPTLYDRFYSSVGGQTVPAQYQDLKYILEQLMGKLQSGKQGRGRASQSPNKRKQPAK 757
                            :::...|.|.|.....|.:.|      ..|.:|:|:.|.:.:..::..|
Human   289 ----------------FTNANFQEVSAHTSSGKDVSE------TRGSEGKGKKSSAHSSGQRGRK 331

  Fly   758 ASPNKKLNNG-ILSSRTSSPEKTVAGSKVGTTTSKVRSPPGKNPTGRRASKSSAAAATSTHNKSQ 821
              |....|.| .:|:.:..|:    ||..||        ||.      ...||.::..|..:...
Human   332 --PGGGRNPGTTVSAASPFPQ----GSFSGT--------PGS------VKSSSGSSVQSPQDFLS 376

  Fly   822 F-HSNIRSSTTSHS--SSGT--ISSGNSSSANGTSSSDSSSGSDSGSESGSSSAGSGVSKRKSSS 881
            | .|::|:.:.|||  ||.|  :..|.|.|..|..:|.|:.       .|..|..:..|:.||..
Human   377 FTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTL-------IGLPSTSAVTSQPKSFE 434

  Fly   882 GSP-------LKKQSYARSVEQRQKQRQRRQNEAVAGASATYPDSRSASSSSDGEDERCRNRQEP 939
            .||       |....|.|                              :.:|..|:|..:.::
Human   435 NSPGDLGNSSLPTAGYKR------------------------------AQTSGIEEETVKEKK-- 467

  Fly   940 ERGARRGPIQSKSVPNRSQASRSKPTTEADVGEGTGASARRKLSTTTRGLAQMDKDADESVSSDE 1004
                |:|..|||..|.|.:.::::                             :..:..||||
Human   468 ----RKGNKQSKHGPGRPKGNKNQ-----------------------------ENVSHLSVSS-- 497

  Fly  1005 SEELLPLRGERQRESTTTSGLATTGSAIGRNLGQHIYSDSESSSSEQEKDQEEQATVESNVSDSQ 1069
                          ::.||.:|:...:|            .|||.::........:::|.   |.
Human   498 --------------ASPTSSVASAAGSI------------TSSSLQKSPTLLRNGSLQSL---SV 533

  Fly  1070 NQQTIRTKAAMKEFVPGTAATTSSTSQAASSTSKAKNTREGKEGAASIGNSTKTKPNPNAKLYPA 1134
            ....:.::.:|:....|...||        :.|:..|......|    .:||.||         .
Human   534 GSSPVGSEISMQYRHDGACPTT--------TFSELLNAIHNDRG----DSSTLTK---------Q 577

  Fly  1135 DLLVVPQRQAAKKA--SENMRSTNLATTLQPDVSDRVREPDINSISGTAKSKVKDSSSRVSNEAD 1197
            :|..:...:..|.|  |:|:|:..:..:  .||:  |..|::.|.||   |....|||.:..::
Human   578 ELKFIVYLEFIKWAYSSQNLRNEGIYNS--NDVA--VSFPNVVSGSG---SSTPVSSSHLPQQS- 634

  Fly  1198 KSSLEKVRPKEHLQKTVGKTSESAPAERGKRGRPPKVPKDARPPSITENDKPALPTHTQSKPPSV 1262
                     ..|||: ||..|.||                                 ..|..|:|
Human   635 ---------SGHLQQ-VGALSPSA---------------------------------VSSAAPAV 656

  Fly  1263 VATPVSAKSNFAVSLVPQRQAAKKAAEQLKSSKPVLESFSTGNDISDKETVTSATISGSGSSVPA 1327
            ..|..:..|..::|..|......::...:.:.....|:..|..|:.|    .|..:.|.|||...
Human   657 ATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGD----NSRNLVGRGSSPRG 717

  Fly  1328 ASTPVKPTRRSSIKEAPITPKEPLSGRRKSKEDLLATPIKTTPLVKRRVVVPNLSSSSSGDSESS 1392
            :.:|     ||.:....|...:|   ...|.|:|.........|::|:.
Human   718 SLSP-----RSPVSSLQIRYDQP---GNSSLENLPPVAASIEQLLERQW---------------- 758

  Fly  1393 SSSSSSGSSSSSGGSDSDSESQASNSENPSSREPPVAPAKVPSDSSLVPKRSPRKSMDKPSALTI 1457
                              ||.|....|..:           |||...:.|
Human   759 ------------------SEGQQFLLEQGT-----------PSDILGMLK--------------- 779

  Fly  1458 APASVNVLNIPSTRSRQ---NSTTKSTKVALQKAVQSVE-DDVKCTPKTNRLQGSMDECGKQVQL 1518
               |::.|.:.:.|..:   |.|.|..::.|..|..||. ..:...|..:.          |:..
Human   780 ---SLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSH----------QIHT 831

  Fly  1519 EQATKRATRGSKSRPPSPTAKSS--PEKTVSRCKSRAEESPKKVANLEQEISQRKVASGKGTSSL 1581
            ..|....|..|.:...||...:|  |:.::                  ..::|...:||:.|||
Human   832 FSAQTAPTTDSLNSSKSPHIGNSFLPDNSL------------------PVLNQDLTSSGQSTSS- 877

  Fly  1582 DKLLNKKQQQMNHSAQATPPPISPTPPASETRIVKDQCDLKPDEVSIQQIN------LGADAQPE 1640
                        .||.:||||...:|....:.:           ..:||:|      |.:..||.
Human   878 ------------SSALSTPPPAGQSPAQQGSGV-----------SGVQQVNGVTVGALASGMQPV 919

  Fly  1641 PDLDPESAAEA---GELPMD--------------IDEELTTAPTRTQLSASASKLADIIDDERPP 1688
            ....|..:|..   |.||.:              :...:|.:...|.|:.:..          ||
Human   920 TSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTV----------PP 974

  Fly  1689 AA--PLPASPTPTPTSNDEMSDAGSDLSERRRMRWRSRRRRRRRSHE-PDEEHT---------HH 1741
            .|  |:||:.|.:.:....:||     .:|:.:..:.:.::...|.: ..|:|.         ||
Human   975 NATHPMPATLTNSASGLGLLSD-----QQRQILIHQQQFQQLLNSQQLTPEQHQAFLYQLMQHHH 1034

  Fly  1742 TQHLLNEMEMARELEEERKNELLANASKYSASTSSPAVTVIPPDPPEIIELDSNSAEQQQQHLHD 1806
            .||...|::   :|:.....::..|  ...|.|.:|.:.....:|  .:.:..::|.|:...|.|
Human  1035 QQHHQPELQ---QLQIPGPTQIPIN--NLLAGTQAPPLHTATTNP--FLTIHGDNASQKVARLSD 1092

  Fly  1807 QPLP 1810
            :..|
Human  1093 KTGP 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	98/360 (27%)
		EPL1	<250..288	CDD:287484
		PHD_JADE	314..359	CDD:277048	21/45 (47%)
		ePHD_RNO	367..480	CDD:277177	50/119 (42%)
		TFIIA	2138..>2295	CDD:281188
MLLT10	XP_024303947.1	PHD_AF10_AF17	24..71	CDD:277049	21/45 (47%)
		RanBP2-type Zn finger	66..85	CDD:275375	5/18 (28%)
		ePHD_AF10	78..206	CDD:277178	55/133 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810