DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and Jade2

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	NP_001344517.1	Gene:	Jade2 / 76901	MGIID:	1924151	Length:	901	Species:	Mus musculus

Alignment Length:	1064	Identity:	337/1064 - (31%)
Similarity:	485/1064 - (45%)	Gaps:	276/1064 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PQPPPTKRRKGRPPNG----ATTAAVAEVTGSGPATG--SERVPVLPLCKSKHEE---PGAEAGG 85
            |:||..  ..|.|..|    |...|.|...|..|:.|  ..|.|      .:|..   |...:..
Mouse     4 PRPPAP--APGAPGFGSILPAPAPAAARSRGQRPSGGHRGARAP------GEHTSPPGPPVPSSL 60

  Fly    86 GGQGRAAAG-----------ATSTSKSKSTK---LAKSASKCKSQGASSSSSWQARSVADIKMSS 136
            ||.|.|...           :.|:..|.:|.   .:.|||:|....:|:.|.|.
Mouse    61 GGLGLAEQSTKQMEEKRRKYSISSDNSDTTDGHVTSTSASRCSKLPSSTKSGWP----------- 114

  Fly   137 IYNRSSTEAPAELYRKDLISAMKLPDSEPLANYEYLIVTDPWKQEWEKGVQVPVNPDSLPEPCVY 201
               |.:.:.|:|::|.|||:|||:|||..|:..:|.|:.|||:||||||||||...:::|||.|.
Mouse   115 ---RQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVR 176

  Fly   202 VLPEPVVSPAHDFKLPKNRYLRITKDEHYSPDLHYLTNVVALAENTCAYDIDPIDEAWLRLYNSD 266
            :|| |:..|..... |.:.    |..|...||.          .....||:|.||..||.|.||:
Mouse   177 LLP-PLKGPPTQMS-PDSP----TLGEGAHPDW----------PGGSRYDLDEIDAYWLELLNSE 225

  Fly   267 RAQCGAFPINATQFERVIEELEVRCWEQIQVILKLEEGLGIEFDENVICDVCRSPDSEEANEMVF 331
            ..:.....::....|||:||||..|.:.:...::.:||||||:||:|:|||||||:.|:.|||||
Mouse   226 LKEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVF 290

  Fly   332 CDNCNICVHQACYGITAIPSGQWLCRTCSMGIKPDCVLCPNKGGAMKSNKSGKHWAHVSCALWIP 396
            ||.||:|||||||||..:|:|.||||||::|::|.|:|||.:|||:|..:||..|.|||||||||
Mouse   291 CDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIP 355

  Fly   397 EVSIGCVDRMEPITKISSIPQSRWSLICVLCRKRVGSCIQCSVKPCKTAYHVTCAFQHGLEMRAI 461
            ||||||.::||||||||.||.|||:|.|.||::..|:|||||:..|.||:||||||..|||||.|
Mouse   356 EVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCITAFHVTCAFDRGLEMRTI 420

  Fly   462 IEEGNAEDGVKLRSYCQKHSMSKGKKENAGSHGGGSASVASAMQKANRYGSGAGGGADDGNNACG 526
            :.:   .|.||.:|.||:||                                      ||.
Mouse   421 LAD---NDEVKFKSLCQEHS--------------------------------------DGG---- 440

  Fly   527 TTGEDPRRRKNHRKTELTSE--ERNQA---------RAQRLQEVEAEFDKHVNFNDISCHLFDVD 580
                 ||       :|.|||  |.:||         |.||||::|..|.:.|...:::..| |:.
Mouse   441 -----PR-------SEPTSEPVEPSQAVEDLEKVTLRKQRLQQLEENFYELVEPAEVAERL-DLA 492

  Fly   581 DDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARKQEQQDM--ENHKLVVHLRQDLERVRNLC 643
            :..:..||.||||||::..|:.|:.||:::|:.:|  |::||:  ...||..|||||||||||||
Mouse   493 EALVDFIYQYWKLKRRANANQPLLTPKTDEVDNLA--QQEQDVLYRRLKLFTHLRQDLERVRNLC 555

  Fly   644 YMVSRREKLSRSLFKLREQVFYKQLGVLDEMRLEKQQTKQEQQQPVMDLNAVIYANDGPTLYDRF 708
            |||:|||:...::.||:||:|:.|:
Mouse   556 YMVTRRERTKHTICKLQEQIFHLQM---------------------------------------- 580

  Fly   709 YSSVGGQTVPAQYQDLKYILEQLMGKLQSGKQGRGRASQSPNK-RKQPAKASPNKKLNNGILSSR 772
                             .::||.:.:..||::.:|:.:.|..| |:.|..:||.||
Mouse   581 -----------------KLIEQDLCREPSGRRSKGKKNDSKRKGREGPKGSSPEKK--------- 619

  Fly   773 TSSPEKTVAG-----SKVGTTTSKVRSPPGKNPTGRRASKSSAAAATSTHNKSQFHSNIRSSTTS 832
                ||..||     .::|.:||                    .....|...|....:::.:...
Mouse   620 ----EKVKAGPESVLGQLGLSTS--------------------FPIDGTFFNSWLAQSVQITAED 660

  Fly   833 HS-SSGTISSGN-SSSANGTSSSDSSSGSD---SGSESGSSSAGSGVSKRKSSSGSPLKKQ---- 888
            .: |..:::||: ...|.|..|.:.....:   |.....|...|....|.:..:..|.||:
Mouse   661 MAMSEWSLNSGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPSPL 725

  Fly   889 ---SYARSVEQRQ-KQRQRRQNEAVAGASATYPDSRSA----SSSSDGE---------------- 929
               ..||:...:| |:...:..:...|.....|..|::    ||.:.|:
Mouse   726 QDGPSARTTPDKQPKKAWAQDGKGTQGPPMRKPPRRTSSHLPSSPAAGDCPVPATLESPPPLASE 790

  Fly   930 --DERC-----RNRQEPERGARRGPIQSKSVPNRSQASRSKPTTEADVGEG--TGASARRKLS-- 983
              |:..     .|.|.|.......|:.....|...:.||..|...:|.|.|  :..:.|.|:|
Mouse   791 ILDKTAPMASDLNVQVPGPTVSPKPLGRLRPPREMKVSRKSPGARSDAGTGLPSAVAERPKVSLH 855

  Fly   984 --TTTRGLAQMDKDADESVSSDES 1005
              |...|....::.:|..|.:::|
Mouse   856 FDTEADGYFSDEEMSDSEVEAEDS 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	198/426 (46%)
		EPL1	<250..288	CDD:287484	15/37 (41%)
		PHD_JADE	314..359	CDD:277048	32/44 (73%)
		ePHD_RNO	367..480	CDD:277177	70/112 (63%)
		TFIIA	2138..>2295	CDD:281188
Jade2	NP_001344517.1	EPL1	209..>578	CDD:331339	199/428 (46%)
		ePHD_JADE2	326..436	CDD:277175	70/112 (63%)
		Atrophin-1	<676..852	CDD:331285	33/175 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3571
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001581
OrthoInspector	1	1.000	-	-		otm43615
orthoMCL	1	0.900	-	-		OOG6_103961
Panther	1	1.100	-	-	O	PTHR13793
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.770