DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and phf14

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	XP_005159744.1	Gene:	phf14 / 555505	ZFINID:	ZDB-GENE-030131-1796	Length:	914	Species:	Danio rerio

Alignment Length:	863	Identity:	185/863 - (21%)
Similarity:	286/863 - (33%)	Gaps:	337/863 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 VICDVCRSPDSEEANEMVFCDNCNICVHQACYGI----TAIPSG-------QWLCRTCSMGIKPD 366
            :||.||...:||:|:|::.||||.:.||:.|||:    .:|.|.       .|.|..|..|:.|.
Zfish   286 LICCVCLGDNSEDADEIIQCDNCGVTVHEGCYGVDGESDSIMSSASENSTEPWFCDACKNGVSPS 350

  Fly   367 CVLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRW-SLICVLCR-- 428
            |.|||::.|..|...:|: |.||.|||::|.|:.|.:|::.|:| ::.:..|:: :..|.||.
Zfish   351 CELCPSQDGIFKETDAGR-WVHVVCALYVPGVAFGDIDKLRPVT-LTEMNYSKYGAKECSLCEDT 413

  Fly   429 --KRVGSCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSYCQKHSMSKGKKENAG 491
              .|.|.||.|....|::.:|||||.:.||...|..||..|:   ...:||::|
Zfish   414 RFARTGVCISCDAGMCRSFFHVTCAQREGLLSEAAAEEDIAD---PFFAYCKQH----------- 464

  Fly   492 SHGGGSASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNH-------------RKTEL 543
                           |:|:                   :...:|||:             |:.:|
Zfish   465 ---------------ADRF-------------------DRKWKRKNYLALQSYCKVSLQEREKQL 495

  Fly   544 TSEERNQAR-AQRLQEVEAEFDKHVNFNDISCHLFDVDDDAIVAIYNYW---------------- 591
            |.|.  ||| ..|||:..|:.:...|...                 ..|
Zfish   496 TPEA--QARITTRLQQYRAKAELSRNTRP-----------------QAWVPREKLPRPLTSSASA 541

  Fly   592 --KLKRKSR---HNRELIPPKSEDVEMIA---RKQEQ----QDMENHKLVVHLRQDLERVRNLCY 644
              ||.||:.   .:.::.|..:.|:....   ||.:|    .|..|:.|..::|
Zfish   542 IRKLMRKAELMGISTDIFPVDTSDISASVDGRRKHKQPALTADFVNYYLERNMR----------- 595

  Fly   645 MVSRREKLSRSLFKLREQVFYKQLGVLDEMRLEKQQTKQEQQQPVMDLNAVIYANDGPTLYDRFY 709
                       :.::::.: .:|..:.|::..|:::...|                    ||:..
Zfish   596 -----------MIQIQDNI-VEQKNLKDKLESEQEKLHME--------------------YDKLC 628

  Fly   710 SSVGG-QTVPAQYQDLKYILEQLMGKLQSGKQGRGRASQSPNKRKQPAKASPNKKLNNGILSSRT 773
            .|:.. |.|..|.:.....:..:||.:...|.......::|.:||
Zfish   629 ESLEDLQNVNGQLRTEGQSIWSMMGGIVGQKLNVPAVLKAPKERK-------------------- 673

  Fly   774 SSPEKTVAGSKVGTTTSKVRSPPGKNPTGRRASKSSAAAATS----THNKSQFHSNIRSSTTSHS 834
              |.|...||            |||       |.|..|...|    ..|:.|....:..:...|.
Zfish   674 --PSKKEGGS------------PGK-------SSSLPAMLYSCGICKKNQDQHLLLLCDTCKLHY 717

  Fly   835 SSGTISSGNSSSANGTSSSDSSSGSDSGSESGSSSAGSGVSKRKSSSGSPLKKQSYARSVEQRQK 899
            ..|.:....:.....|                                    |.||.:..|..|.
Zfish   718 HLGCLDPPLTRMPKKT------------------------------------KNSYWQCSECDQA 746

  Fly   900 QRQRRQNEAVAGASATYPDSRSASSSSDGEDERCRNRQEPERGARRGPIQSKSVPNRSQASRSKP 964
            .    .:||.. |..|.||....|                 |...:|||  |.:|........||
Zfish   747 S----SDEADI-AMETLPDGTKRS-----------------RRQIKGPI--KFIPQEMSPEPKKP 787

  Fly   965 TTEADVGEGTGASARRKLSTTTRGLAQMDKDADESVSSDES-EELLPLRGERQREST-------- 1020
            ...               .|.|||    .|....|:..:|. ||.|| |..|||:||
Zfish   788 QVR---------------GTRTRG----QKRKRMSICEEEKMEEPLP-RERRQRQSTLQKKPKAD 832

  Fly  1021 TTSGLATTGSAIGRN----------LGQH-------------------IYSDSESSSSEQEKDQE 1056
            .|....||....|.|          |..|                   |..:.::|||::|:.||
Zfish   833 DTRTECTTCKGPGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDTSSSKEEEAQE 897

  Fly  1057 EQATVESNVSDSQNQQTI 1074
            .:   |.:|::...:|.|
Zfish   898 VE---EESVNEETAEQEI 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	98/408 (24%)
		EPL1	<250..288	CDD:287484
		PHD_JADE	314..359	CDD:277048	21/55 (38%)
		ePHD_RNO	367..480	CDD:277177	42/117 (36%)
		TFIIA	2138..>2295	CDD:281188
phf14	XP_005159744.1	EPL1	<287..>619	CDD:331339	101/423 (24%)
		ePHD_PHF14	351..464	CDD:277144	42/117 (36%)
		PHD2_PHF14	694..743	CDD:277037	9/84 (11%)
		PHD3_PHF14	837..885	CDD:277038	7/47 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920