DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and CG15439

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	NP_608836.1	Gene:	CG15439 / 33651	FlyBaseID:	FBgn0031606	Length:	1008	Species:	Drosophila melanogaster

Alignment Length:	1015	Identity:	221/1015 - (21%)
Similarity:	369/1015 - (36%)	Gaps:	302/1015 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 ICDVCRSPDSEEANEMVFCDNCNICVHQACYGIT---AIPSGQ-------WLCRTCSMGI-KPDC 367
            :|.||....|::.||:|.||:|.:.||:.|||::   :|.|..       |.|..|..|: :|||
  Fly   120 MCCVCLGERSDDVNEIVECDSCGVSVHEGCYGVSDNVSISSTNSTCSTEPWFCEACRAGVSEPDC 184

  Fly   368 VLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRW-SLICVLCRK-- 429
            .|||||||..|....|| |.|:.|||::|.|:.|.|:::..:| :..:..|:| :.:|.||..
  Fly   185 ELCPNKGGIYKETDVGK-WVHLICALYVPGVAFGEVEQLSSVT-LFEMQYSKWGAKVCSLCENAL 247

  Fly   430 --RVGSCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSYCQKHS---MSKGKKEN 489
              |.|.||.|....|||.:|||||...|..:.|..|:..|:   ...::|:.||   |.|.::.|
  Fly   248 FARTGVCIGCDAGMCKTYFHVTCAQVAGFLIEAHHEDDAAD---PFYAHCKVHSEKEMIKKRRRN 309

  Fly   490 AGSHGGGSASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNHRKTELTSEERNQARAQ 554
            .      .....:.||:|..            ..|.....|.|....|..          |||.|
  Fly   310 Y------HTLRLNMMQRARE------------KEALAAEHETPAPHPNPA----------QARIQ 346

  Fly   555 R-LQEVEAEFDKHVNFNDISCHLFDVDDDAIVAIYNYW-KLKRKSRHNRELIPPKSEDVEMIARK 617
            | |.:::.::.:|.......                 | ..::.||    |:...:.....:..|
  Fly   347 RKLLKIQHKYTRHKELKPTP-----------------WVPTQKMSR----LLTTSASACRRLLAK 390

  Fly   618 QEQQDMENHKLVVHLRQDLERVRNLCYMVSRREKLS-RSLFKLREQVFYKQLGVLDEMRLEKQQT 681
            .|...::    |.||.|   |..::..:...|:|.. ...|.:....:|..       |:.:...
  Fly   391 AEIMSVD----VQHLEQ---REAHINALTDIRKKWHIAPAFSVEFTAYYMD-------RIVRMDD 441

  Fly   682 KQEQQQPVMDLNAVIYANDGPTL---YDRFYSSVGGQTVPAQYQDLKYILEQLMGKLQSGKQGRG 743
            .::||:.::..||:: :.|...|   ||         |...:.:.:|...:.|:..::|.....|
  Fly   442 FRQQQRELISHNAIL-SKDQDVLRAQYD---------TALEERKAVKATKDSLLTSIKSLHTALG 496

  Fly   744 RASQSPNKR-------KQPAKASPNKKLNNGILSSRTSSPEK-----TVAGSKVGTTTSKVRSPP 796
            :.  :||..       ..|...:|.|       :|..:.|::     |.|..|:|     |..|.
  Fly   497 QI--APNMTLPSVDLIAHPLPEAPPK-------TSTPTPPQRPISVPTAAALKMG-----VGFPL 547

  Fly   797 GK-NPTGRRASKSSAAAATSTHNKSQFHSNIRSSTTSHSSSGTISSG------------------ 842
            |. .|.|   ||..::...|||.|...||   :|:.|..::.::|.|
  Fly   548 GHLGPPG---SKMDSSRMLSTHAKQGKHS---TSSASVEAAPSVSCGICKRSKDQHLLVKCDTCN 606

  Fly   843 ----------------NSSSANGTSSS---DSSSGSDSGSESGSSSAGSGVSKRKSSSGSPLKKQ 888
                            ..|...|...|   |.|.|||:.:|         :|.....|.:...|.
  Fly   607 LHYHLGCLNPPLTRPPKKSKQYGWQCSECCDKSEGSDAVTE---------ISSGPRKSRTRFNKD 662

  Fly   889 SYARSVEQ--------------RQKQRQRRQNEAVAGASATYPDSRSASSSSDGEDERCRNRQEP 939
            .:...|::              ::...:|..|:::...:..|.:..:.|               |
  Fly   663 GHLVYVDRYSLDDIPVAAVNVPKESHTKRALNKSLPAPAPEYIEDLTKS---------------P 712

  Fly   940 ERGARRGPIQSKSVPNRSQASRSKPTTEADVGEGTGASARRKLSTTTRGLAQMDKDADESVSSDE 1004
            :|...:.|.::   |....|....|||:|.....:.|:.....:..|.....::....|. |.|:
  Fly   713 KRPKLQSPCKT---PINVPAENVTPTTDAAPVAASAATPAAAPTLPTPNTIVINLSGCED-SIDD 773

  Fly  1005 SEELLPLRGERQRESTTTSGLATTGSAIGRNLGQHIYSDSESS-SSEQEKDQEEQATVE---SNV 1065
            |...|..:|:|:.:......|:               ||:|.| ..|.::.::::|.::   :::
  Fly   774 SSGKLSRKGKRKDKHKNKHNLS---------------SDTEKSIGKEHKRKRKKRAHLDESSTHL 823

  Fly  1066 SDSQNQQTIRTKAAMKEF-VPGTAATTS-----------STSQAASSTS---------------- 1102
            .::.|......|...|.. :||..|..|           |..:|:..||
  Fly   824 DNAGNTSGSTIKIIFKALRLPGEDAPESQYFYVPANAVRSVDEASRPTSVETVEDSVQGAEQALA 888

  Fly  1103 -------KAKNTREGKEGAASIGNSTKTKPNPNAKLYPADLLVVPQRQAAKKASENMRSTNLATT 1160
                   ..:..||.||.|||.  |....|:|..|:.|            :|||..
  Fly   889 PIVLPAASPQKVREPKETAASA--SVNPTPSPKRKVSP------------RKASPR--------- 930

  Fly  1161 LQPDVSDRVREPDINSISGTAKSKVKDSSSRVSNEADKSS 1200
                 ..||..|.:::    ||..| :.|..|.::..||:
  Fly   931 -----KPRVGRPRVSN----AKPNV-EISCCVCSQTGKSN 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	100/371 (27%)
		EPL1	<250..288	CDD:287484
		PHD_JADE	314..359	CDD:277048	19/54 (35%)
		ePHD_RNO	367..480	CDD:277177	44/117 (38%)
		TFIIA	2138..>2295	CDD:281188
CG15439	NP_608836.1	PHD1_PHF14	120..175	CDD:277036	19/54 (35%)
		ePHD_PHF14	184..297	CDD:277144	44/117 (38%)
		PHD2_PHF14	586..635	CDD:277037	5/48 (10%)
		PHD3_PHF14	949..997	CDD:277038	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13793
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850