DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rno and jade1

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	NP_956099.1	Gene:	jade1 / 327437	ZFINID:	ZDB-GENE-030131-5648	Length:	829	Species:	Danio rerio

Alignment Length:	875	Identity:	313/875 - (35%)
Similarity:	456/875 - (52%)	Gaps:	115/875 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 SQGASSSSSWQARSVADIKMSSIYNRSSTEAPAELYRKDLISAMKLPDSEPLANYEYLIVTDPWK 179
            |...|:|:||...|      :|.:.:.|.:.|:|::|.|||:||||.||..|...:|..:.|||:
Zfish    13 SDNGSNSTSWSQHS------NSKHRKQSGKRPSEVFRTDLITAMKLHDSHQLNPEDYYELADPWR 71

  Fly   180 QEWEKGVQVPVNPDSLPEPCVYVLPEPVVSPAHDFKLPKNRYLRITKDEHYSPDLHYLTNVVALA 244
            |||||||||||:|:|:|:..|..:.|...:|.  |..|| :.:|.::    |..|.|: .:..||
Zfish    72 QEWEKGVQVPVSPESIPQCAVRTVAEKSTAPL--FIKPK-KLIRSSE----SSMLGYV-GIQTLA 128

  Fly   245 ENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEELEVRCWEQIQVILKLEEGLGIEF 309
            :..|.||::..|.|||::.|.:.::.|..|::....|||:||.|.||::.:...::.|||||||:
Zfish   129 DGMCRYDLNEEDVAWLQITNEEFSKMGMQPLDELTMERVMEEFERRCYDNMSHAMETEEGLGIEY 193

  Fly   310 DENVICDVCRSPDSEEANEMVFCDNCNICVHQACYGITAIPSGQWLCRTCSMGIKPDCVLCPNKG 374
            ||:|:||||:|||.|:.|||||||.||||||||||||..:|.|.||||||::||.|.|.|||.||
Zfish   194 DEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGIFPKCHLCPKKG 258

  Fly   375 GAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLCRKRVGSCIQCSV 439
            ||||..:||..|.||||||||||||||..::|||||.:|.||.:||:|||.||:::.|:|||||.
Zfish   259 GAMKPTRSGTKWVHVSCALWIPEVSIGNPEKMEPITNVSHIPSNRWALICCLCKEKTGACIQCSA 323

  Fly   440 KPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSYCQKHSMSKGKKENAGSHGGGSASVASAM 504
            |.|:.|:||||....||:|..|:.|.   |.||.:|:|.|||.....:|.
Zfish   324 KSCRVAFHVTCGLHCGLKMNTILTEA---DEVKFKSFCPKHSGLDWNEEE--------------- 370

  Fly   505 QKANRYGSGAGGGADDGNNACGTTGEDPRRRK--------NHRKTELTSEERNQARAQRLQEVEA 561
                         .||.......|.||..|.:        ..|.::...|.|...|..|:|::|.
Zfish   371 -------------GDDDRPVKVPTREDRSRNRGIDFSASSQTRLSQNPEETRLSERKLRVQQLED 422

  Fly   562 EFDKHVNFNDISCHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARKQEQQDMENH 626
            ||.:.|..::::.|| .:..:.:..::.|||||||...|:.||.||.|:.:.:||::::..:...
Zfish   423 EFYRFVAADEVAEHL-QLPLEMVDILFQYWKLKRKVNFNQPLIMPKKEEEDSLARREQEVLLRRL 486

  Fly   627 KLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFYKQLGVLDEMRLEKQQTKQEQQQPVMD 691
            :|..||||||||||||.|||||||::.|:|.:::||:|:..:.:|::.|:....:.:..::
Zfish   487 RLFTHLRQDLERVRNLTYMVSRRERIKRTLCRVQEQIFHHHVRLLEQGRVTGVSSTRRLEE---- 547

  Fly   692 LNAVIYANDGPTLYDRFYSSVGGQTVPAQYQDLKYILEQLMGKLQSGKQGRGRASQSPNKRKQPA 756
              |:.|....|             .|||..|.||....| ...|.|.::|    |.|....|...
Zfish   548 --AMFYFRTTP-------------PVPASPQPLKGHCGQ-NSTLSSSEKG----SNSYRSSKHIE 592

  Fly   757 KASPNKKLNNGILSSRTSSPEKTVAGSKVGTTTSKVRS-------PPGKNPTGRRASKSSAAAAT 814
            ...|.|.|.:|:.||..|...:||..:....:..:.||       ...:.|...|..||......
Zfish   593 ADKPAKMLMDGVPSSGDSVRSETVMSASSRRSEGRTRSGESHRKEEESERPLEDRRRKSKLWDQV 657

  Fly   815 STHNKSQFHSNIRSSTTSHSSSGTISSGNSSSANGTSSSDSSSGSDSGSESGSSSAGSGVSKRKS 879
            |..:|.:...::..:.:|.:...|:......|....:|..::....|||...::::..|......
Zfish   658 SIKDKLRHAKSMEDTLSSETELDTMDDRLLLSHTNANSVATAPNMYSGSPRKTNASHQGKLVPNG 722

  Fly   880 SSGSPLK--------KQSYARSVEQRQKQRQRRQNEAVAGAS----ATYPDS------------- 919
            :||..||        |:| .|:...||.:||...|.|...:|    :|.|.|
Zfish   723 TSGRHLKNWGSFRIPKRS-ERTSAGRQTERQEADNTADQNSSLKTFSTSPSSPQIRTRLRTGSEN 786

  Fly   920 -RSASSSSDGEDE---RCRNRQEPERGARR 945
             |....|..|:.|   ||..::.|....||
Zfish   787 RRHLEESDLGQSEQGKRCHTQRLPSPMTRR 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	191/421 (45%)
		EPL1	<250..288	CDD:287484	14/37 (38%)
		PHD_JADE	314..359	CDD:277048	33/44 (75%)
		ePHD_RNO	367..480	CDD:277177	65/112 (58%)
		TFIIA	2138..>2295	CDD:281188
jade1	NP_956099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		9/32 (28%)
		EPL1	<104..173	CDD:287484	24/74 (32%)
		PHD_JADE1	198..243	CDD:277149	33/44 (75%)
		ePHD_JADE	251..361	CDD:277141	65/112 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..408		8/67 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..651		27/112 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..829		30/121 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	171	1.000	Domainoid score	I3693
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001581
OrthoInspector	1	1.000	-	-		otm24281
orthoMCL	1	0.900	-	-		OOG6_103961
Panther	1	1.100	-	-	LDO	PTHR13793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.800