DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and jade3

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	NP_970614.2	Gene:	jade3 / 322209	ZFINID:	ZDB-GENE-030131-928	Length:	795	Species:	Danio rerio

Alignment Length:	859	Identity:	311/859 - (36%)
Similarity:	434/859 - (50%)	Gaps:	167/859 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 SSSSSWQARSVADIKMSSIYN------RSSTEAPAELYRKDLISAMKLPDSEPLANYEYLIVTDP 177
            |||.|....|.:....|:.|.      .|:.:.|||::|||||||||||||..:::.:|.::.|.
Zfish     8 SSSDSSDNESPSTSFSSNKYGSKPGTPASAQKKPAEVFRKDLISAMKLPDSHHISSEDYYLLADT 72

  Fly   178 WKQEWEKGVQVPVNPDSLPEPCVYVL---PEPVVSPAHDFKLPKNRYLRITKDEHYSPDLHYLTN 239
            |||||||||||..:||::|:|.|.::   |:.|:     |..|: :|::....:  |.:..|: |
Zfish    73 WKQEWEKGVQVLASPDTIPQPSVRIITEKPKEVL-----FSKPR-KYIQCWSQD--STETGYV-N 128

  Fly   240 VVALAENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEELEVRCWEQIQVILKLEEG 304
            :..|||..|.||:|.:|..||:..|::....|...::....|||:|.||.:|.|.:...::.|||
Zfish   129 IKELAEAMCRYDLDDMDLYWLQQLNAELGMMGDGVVDELTMERVMEALERQCHENMNHAIETEEG 193

  Fly   305 LGIEFDENVICDVCRSPDSEEANEMVFCDNCNICVHQACYGITAIPSGQWLCRTCSMGIKPDCVL 369
            ||||:||:|||||||||||||.|:|||||.||||||||||||..:|.|.||||||.:||.|.|:|
Zfish   194 LGIEYDEDVICDVCRSPDSEEGNDMVFCDKCNICVHQACYGIVKVPDGNWLCRTCVLGITPQCLL 258

  Fly   370 CPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLCRKRVGSC 434
            ||..|||||:.::|..|||||||||||||||.|.:|||||||:|.||.|||||||.||:.:.|:|
Zfish   259 CPKTGGAMKATRAGTKWAHVSCALWIPEVSIACPERMEPITKVSHIPPSRWSLICSLCKLKTGAC 323

  Fly   435 IQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSYCQKHSMSKGKKENAGSHGGGSAS 499
            ||||||.|...:||||||:|.|||:.|::||   |.||.:|||.|||..|
Zfish   324 IQCSVKNCTIPFHVTCAFEHSLEMKTILDEG---DEVKFKSYCLKHSKPK--------------- 370

  Fly   500 VASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNHRKTELTSEERNQARAQRLQEVEAEFD 564
                                     .|..|..|.|.|...:|:..|     .|||:|||:|.||.
Zfish   371 -------------------------AGEPGLSPARHKPPTETDKLS-----LRAQKLQELEEEFY 405

  Fly   565 KHVNFNDIS------CHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARKQEQQDM 623
            .:|:..:::      .||.|.       |:.|||:||||..|:.|:|||.::..::.:.||....
Zfish   406 TYVHPEEVAHDLSLPLHLLDF-------IFQYWKMKRKSNFNKALLPPKEDEENLLLQPQEDSIH 463

  Fly   624 ENHKLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFYKQLGVLDE--------------- 673
            ...::.:||||||||||||||||||||||..|..|.:||:|...:.::::
Zfish   464 TRMRMFMHLRQDLERVRNLCYMVSRREKLKLSQSKAQEQIFNLHVKLVNQELSAGLPVSSSIENL 528

  Fly   674 -----------MRLEKQQTKQEQQQPVMDLNAVIYANDGPTLYDRFYSSVGGQTVPAQYQDLKYI 727
                       :::.|.|....:...... |..:..::...|||.....: ||..|..:...:.|
Zfish   529 LFHPPPRITLKLKMPKVQLGNGKSSSKSG-NGPLCPDNSCNLYDTSEGGI-GQGKPQLHLGRQRI 591

  Fly   728 LEQLMGKL------------------QSGK--------QGRGRASQSPNKRKQPAKASPNKKLNN 766
            .|::.|.|                  ||||        .|:....::.|:.::..:...|..|:.
Zfish   592 EERINGILPASIYIRRDGGTPPLAVKQSGKPLALHAALHGQSSNGKTKNEAEKTRQIKSNGILDK 656

  Fly   767 GILSSRTS-------SPEKTVAGSKVGTTTSKVRSPPGKNPTG----RRASKSSAAAATSTHNKS 820
            .||...||       .|...::|..         .|.|.:.|.    .|:.|.:..:...|.:..
Zfish   657 PILQRDTSCLAASEKDPRSEISGKS---------QPSGFHKTSLEHFSRSLKEATVSLVRTEDLR 712

  Fly   821 QFHSNIRSSTTSHSSSGTISSGNSSSANGTSSSDSSSG-------SDSGSESGSSSAGSGVSKRK 878
            .|..|.|.|:.......|     .....|..:|..|.|       |||..|:.......|  :.:
Zfish   713 TFEKNSRKSSGFSKPLST-----ERPQGGGRASQESDGYCPDAELSDSEPEAKGKCRQGG--RTQ 770

  Fly   879 SSSGSPLKKQSYAR 892
            :..|..:|..|.|:
Zfish   771 NQRGDYVKSASRAK 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	205/419 (49%)
		EPL1	<250..288	CDD:287484	12/37 (32%)
		PHD_JADE	314..359	CDD:277048	36/44 (82%)
		ePHD_RNO	367..480	CDD:277177	73/112 (65%)
		TFIIA	2138..>2295	CDD:281188
jade3	NP_970614.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		8/32 (25%)
		EPL1	<89..178	CDD:287484	28/97 (29%)
		COG5141	139..555	CDD:227470	208/470 (44%)
		PHD_JADE3	203..252	CDD:277151	38/48 (79%)
		ePHD_JADE3	256..366	CDD:277176	73/112 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..654		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..687		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	714..795		18/78 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596274
Domainoid	1	1.000	171	1.000	Domainoid score	I3693
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001581
OrthoInspector	1	1.000	-	-		otm24281
orthoMCL	1	0.900	-	-		OOG6_103961
Panther	1	1.100	-	-	O	PTHR13793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.730