DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and Jade1

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	XP_006232363.1	Gene:	Jade1 / 310352	RGDID:	1306920	Length:	847	Species:	Rattus norvegicus

Alignment Length:	897	Identity:	310/897 - (34%)
Similarity:	458/897 - (51%)	Gaps:	165/897 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 SASKCKSQGASSSSSWQARSVADIKMSSIYNRSSTEAPAELYRKDLISAMKLPDSEPLANYEYLI 173
            |:|:......|.|::|...|.:....|:. :|.....|:|::|.|||:||||.||..|...||.:
  Rat    23 SSSEDSDDNGSLSTTWSQHSRSQHGRSTC-SRHEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYV 86

  Fly   174 VTDPWKQEWEKGVQVPVNPDSLPEPCVYVLPEPVVSPAHDFKLPKNRYLRITKDEHYSPDLHYLT 238
            :.|||:|||||||||||:|.::|:|...|:.|   ..:..|..|| :|:..:..|  .|:|.|:
  Rat    87 LADPWRQEWEKGVQVPVSPGTIPQPVARVVSE---EKSLMFIRPK-KYIASSGSE--PPELGYV- 144

  Fly   239 NVVALAENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEELEVRCWEQIQVILKLEE 303
            ::..||::.|.||::.:|.|||.|.|.:..:.|...::....|||:||.|.||::.:...::.||
  Rat   145 DIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEE 209

  Fly   304 GLGIEFDENVICDVCRSPDSEEANEMVFCDNCNICVHQACYGITAIPSGQWLCRTCSMGIKPDCV 368
            |||||:||:|:||||:|||.|:.|||||||.||||||||||||..:|.|.||||||::|::|.|:
  Rat   210 GLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCL 274

  Fly   369 LCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLCRKRVGS 433
            |||.||||||..:||..|.||||||||||||||..::||||||:|.||.|||:|:|.||.::.|:
  Rat   275 LCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGA 339

  Fly   434 CIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSYCQKHSMSKGKKENAGSHGGGSA 498
            .||||||.|:||:||||||..||||:.|:.|   .|.||.:|||.|||..:..:|:.|.
  Rat   340 SIQCSVKNCRTAFHVTCAFDRGLEMKTILAE---NDEVKFKSYCPKHSSHRKPEESLGE------ 395

  Fly   499 SVASAMQKANRYGSGAGGGADDGNNACGTTGE-------DPRRRKNHRKTELTSEERNQARAQRL 556
                            |...::|...|.....       :..|.:.||.:         .|.|:|
  Rat   396 ----------------GAAQENGATECSPQSPLEPFASLEQNREEAHRVS---------VRKQKL 435

  Fly   557 QEVEAEFDKHVNFNDISCHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARKQEQQ 621
            |::|.||...||..|:: ....:.::.:..:|.|||||||...|:.||.||.::.:.:|::::..
  Rat   436 QQLEDEFYTFVNLLDVA-RALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDNLAKREQDV 499

  Fly   622 DMENHKLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFYKQLGVLDEMRLEKQQTKQEQQ 686
            .....:|..||||||||||||.|||:||||:.||:.|::||:|.....:|::.::....:.....
  Rat   500 LFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFSLYAKLLEQGKVSGVPSSCSSL 564

  Fly   687 QPVMDLNAVIYANDGPTLYDRFYSSVGGQTVPAQYQDLKY---ILEQLMGK--LQSGKQGRGR-- 744
            :.::..|:       |::         |..|| :.:|||:   ...:.||.  :.|.|:...|
  Rat   565 ENMLLFNS-------PSV---------GPNVP-KIEDLKWHSAFFRKQMGTNLVHSLKKSHKRDA 612

  Fly   745 -----ASQSPNKRKQPAKASPNKKLNNGILSSRTSSPEKTVAGSKVGTTTSKVRSPPGKNPTGRR 804
                 .::.....|||..:  .::..:|:..|..|. |||.|.:::      :.|...||
  Rat   613 LQNSSGTEGKTLLKQPGLS--GRREGSGVPESLLSF-EKTFAEARL------ISSAQQKN----- 663

  Fly   805 ASKSSAAAATSTHNK--------------------SQFHSNIRSSTTSH----SSSGTISSGNSS 845
                  ...|..|.|                    .|.|..:||:.||.    ::....|.|...
  Rat   664 ------GVVTPDHGKRRDNRFHCDLVKGDLKDKSFKQSHKPLRSTDTSQRHLDNTRAATSPGVGQ 722

  Fly   846 SANGT-------------------SSSDSSSGS----DSGSESGSSSAGSGVSKRKSS------S 881
            ||.||                   :|...|.|.    ..|.......|..|...:.|.      |
  Rat   723 SAPGTRKEIVPKCNGSLVKVPTTPASPVKSWGGFRIPKKGERQQQGEAHDGACHQHSDCSHLGIS 787

  Fly   882 GSPLKKQSYARSVEQRQKQRQRRQNEAVAGASATYPDSRSASSSSDGEDERC 933
            .:|.|::|       :.:.|...:|:..|      ||...:.|.|:..:::|
  Rat   788 RAPAKERS-------KSRLRTDSENDGYA------PDGEMSDSESEASEKKC 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	195/420 (46%)
		EPL1	<250..288	CDD:287484	14/37 (38%)
		PHD_JADE	314..359	CDD:277048	33/44 (75%)
		ePHD_RNO	367..480	CDD:277177	71/112 (63%)
		TFIIA	2138..>2295	CDD:281188
Jade1	XP_006232363.1	EPL1	<107..195	CDD:287484	29/94 (31%)
		PHD_JADE1	220..265	CDD:277149	33/44 (75%)
		ePHD_JADE1	270..387	CDD:277174	75/119 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3917
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001581
OrthoInspector	1	1.000	-	-		otm45690
orthoMCL	1	0.900	-	-		OOG6_103961
Panther	1	1.100	-	-	LDO	PTHR13793
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.770