DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and Jade3

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	XP_038955504.1	Gene:	Jade3 / 299305	RGDID:	1563945	Length:	850	Species:	Rattus norvegicus

Alignment Length:	926	Identity:	328/926 - (35%)
Similarity:	451/926 - (48%)	Gaps:	195/926 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 AKSASKCKSQGASSSSSWQARSVADIKMSSIYNRSSTEAPAELYRKDLISAMKLPDSEPLANYEY 171
            ::|:.:|.|...:|.|.::.:|         .|....:..||::|||||||||:|||..:....|
  Rat    11 SESSDECPSTSFTSGSMYRKKS---------KNPKEHKKSAEVFRKDLISAMKIPDSHHINPDSY 66

  Fly   172 LIVTDPWKQEWEKGVQVPVNPDSLPEPCVYVLPEPVVSPAHDF-------KLPKNR--------- 220
            .:.||.||:|||||||||.||||:|.|.:......:.:|...|       .||..|
  Rat    67 YLFTDTWKEEWEKGVQVPANPDSVPTPSLRSRNRTLPTPQKPFFCSLPVTDLPHRRIISEKVKEI 131

  Fly   221 -------YLRITKDEHYSPDLHYLTNVVALAENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINAT 278
                   |:|.:..|...|.  |: |.:.||.:||.||:|.:|..||:..|.|..:.|..||:.|
  Rat   132 LFVRPRKYIRCSSPESAEPG--YI-NTLELAASTCRYDLDDMDIFWLQELNEDLGEMGYGPIDET 193

  Fly   279 QFERVIEELEVRCWEQIQVILKLEEGLGIEFDENVICDVCRSPDSEEANEMVFCDNCNICVHQAC 343
            ..|:.||.||..|.|.:...::..||||||:||:|||||||||||||.|:|||||.||:||||||
  Rat   194 LMEKTIEVLERHCHENMNHAIETVEGLGIEYDEDVICDVCRSPDSEEGNDMVFCDKCNVCVHQAC 258

  Fly   344 YGITAIPSGQWLCRTCSMGIKPDCVLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEP 408
            |||..||.|.||||:|.:||.|.|||||.||||||:.::|..|||||||||||||||.|.:||||
  Rat   259 YGILKIPEGSWLCRSCVLGIYPQCVLCPKKGGAMKTTRTGTKWAHVSCALWIPEVSIACPERMEP 323

  Fly   409 ITKISSIPQSRWSLICVLCRKRVGSCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKL 473
            :||||.||.|||:|:|.||:.:.|:|||||||.|.||:||||||:|||||:.|::||   |.||.
  Rat   324 VTKISHIPPSRWALVCNLCKLKTGACIQCSVKSCITAFHVTCAFEHGLEMKTILDEG---DEVKF 385

  Fly   474 RSYCQKHSMSKGKKENAGSHGGGSASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNH 538
            :|:|.|||.:|.|..:|..|                                           :|
  Rat   386 KSFCLKHSQNKPKLGDAEYH-------------------------------------------HH 407

  Fly   539 RKTELT--SEERNQARAQRLQEVEAEFDKHVNFNDISCHL----FDVDDDAIVAIYNYWKLKRKS 597
            |..|.:  ..|:...|||:|:|:|.||...|...|::..:    |.||     .|||||||||||
  Rat   408 RAAEQSQAKSEKTSLRAQKLRELEEEFYTLVQVEDVAKEMGLSAFTVD-----FIYNYWKLKRKS 467

  Fly   598 RHNRELIPPKSEDVEMIARKQEQQDMENHKLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQ 662
            ..|:.|||||.::...:.:.:|:......::.:|||||||||||||||:||||||..|..|::||
  Rat   468 NFNKPLIPPKEDEQNGLVQPKEESIHTRMRMFMHLRQDLERVRNLCYMISRREKLKLSHTKVQEQ 532

  Fly   663 VFYKQLGVLDEMRLEKQQTKQEQQQPVMDLNAVIYANDGPTLYDRFYSSVGGQTVPAQYQDLKYI 727
            :|..|:.:::|                       ...||.:|.:...:|:       .|...:..
  Rat   533 IFGLQVQLINE-----------------------EITDGLSLTNALENSL-------FYPPPRIT 567

  Fly   728 LEQLMGKLQS-----------------GKQGRGRASQSPNKRKQPAKAS-------PNKKLNNGI 768
            |:..|.|..|                 |......:.:||...::|...:       |.:..:|.:
  Rat   568 LKLKMPKSTSEDCRDSSTETEHQPSSPGSSSPSHSKRSPEMPEEPLDMNVKIYPRYPLESKSNCV 632

  Fly   769 LSSRTSSPEKTVAGSKV----------GTTTSKVRSPP---------------GKNPTGRRASKS 808
            |:||:.|..:|.:.|..          |.|..|    |               |||....|.:.|
  Rat   633 LASRSHSQSETRSSSPTQRAPSAEFYHGQTLGK----PLALQAALHGQASIGNGKNQPNSRLASS 693

  Fly   809 SAAAATSTHNKSQFHSNIRSSTTSHSSSGTISSGNSSSANGTSSSDSSSGSDSGSESGSSSAGSG 873
            :......:.|.:|   .:.|....:.....:||...||.|     ...||.:..|.|...:..:.
  Rat   694 NGLEGNWSGNITQ---KVNSGEMCYDQESMLSSHLPSSGN-----IRKSGMEHFSRSFKEATNTW 750

  Fly   874 VSKR-------KSSSGSPLKKQSYARSVEQRQKQRQRRQNEAVAGASATYPDSRSASSSSDGEDE 931
            |...       |.:.....|:|.:.|.:.:|...|...|.     .....||...:.|.::||..
  Rat   751 VKPNEDLQYCVKPTKNVSSKEQLWGRPLLRRSTGRASYQE-----TDGYCPDLEPSDSEAEGEGN 810

  Fly   932 RCRNRQEPERGARRGP 947
            :...|.:.|...|..|
  Rat   811 KETVRVKRESSDRENP 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	210/419 (50%)
		EPL1	<250..288	CDD:287484	15/37 (41%)
		PHD_JADE	314..359	CDD:277048	36/44 (82%)
		ePHD_RNO	367..480	CDD:277177	75/112 (67%)
		TFIIA	2138..>2295	CDD:281188
Jade3	XP_038955504.1	EPL1	<74..204	CDD:402235	47/132 (36%)
		COG5141	165..>536	CDD:227470	211/421 (50%)
		PHD_SF	282..392	CDD:419867	75/112 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9204
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001581
OrthoInspector	1	1.000	-	-		otm45690
orthoMCL	1	0.900	-	-		OOG6_103961
Panther	1	1.100	-	-	O	PTHR13793
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910