DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rno and Brpf3

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	NP_001074784.1	Gene:	Brpf3 / 268936	MGIID:	2146836	Length:	1204	Species:	Mus musculus

Alignment Length:	1160	Identity:	273/1160 - (23%)
Similarity:	411/1160 - (35%)	Gaps:	350/1160 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SKCKSQGASSSSSW--------------QARSVADIKMSSIYNRSSTEAPAELYRKDLISAMKLP 161
            |:..::|..|.|.:              ||:.:.::.:....:|.|...|.::..:|.::|..:.
Mouse     8 SRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDIT 72

  Fly   162 DSEPLANYEYLIVTDPWKQEWEKGVQVPV---NPDS------------------LPEPCVYVL-- 203
            :...             .:|..:..|.|.   .|.|                  ||:|...|:
Mouse    73 ECNS-------------NKENSEQPQFPAKSKKPSSKGKRKESCSKHASGTSFHLPQPSFRVVDT 124

  Fly   204 -PEPVVSPAHDFKLPKNRYLRITKDEHYSPDLHYLTNVVALAENTCAYDIDPIDEAWLRLYNSDR 267
             .:|...|     ||...|..|.|...   ||          :....||:|..|.|||.:.|..|
Mouse   125 GSQPEAPP-----LPAAYYRYIEKPPE---DL----------DAEVEYDMDEEDIAWLDMVNEKR 171

  Fly   268 AQCGAFPINATQFERVIEELEVRCWEQIQVILKLEEGLGIE---FDENVICDVCRSPDSEEANEM 329
            ...|...::|..||.:::.||...:.:       ....|.:   .||:..|.||...:...:|.:
Mouse   172 RADGHSSVSADTFELLVDRLEKESYLE-------SRSSGAQQSLIDEDAFCCVCLDDECHNSNVI 229

  Fly   330 VFCDNCNICVHQACYGITAIPSGQWLCRTC--SMGIKPDCVLCPNKGGAMKSNKSGKHWAHVSCA 392
            :|||.||:.|||.|||:..||.||||||.|  |.....|||||||||||.|....| |||||.||
Mouse   230 LFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDG-HWAHVVCA 293

  Fly   393 LWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLCR-KRVGSCIQCSVKPCKTAYHVTCAFQHGL 456
            :|||||.......:|||..|.:||.:||.|.|.:|: |.:|:.|||....|.||:|||||.:.||
Mouse   294 IWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGL 358

  Fly   457 EMRAIIEEGNAEDG----VKLRSYCQKHSMS------KGKK---------ENAGSHGGGSASVAS 502
            .|:.......:.:|    |:..:||:.||.|      ||..         |:....|||.    .
Mouse   359 FMKIEPMRETSLNGTTFTVRKTAYCEAHSPSVAVARRKGDSPRSLSEVGDEDGPKEGGGE----E 419

  Fly   503 AMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNHRKTELTSEERNQARAQRLQEVEAEFDKHV 567
            ..::|...|....||...........|:...::|..::.|   |...:|.:..|..|........
Mouse   420 EQEEAEEEGQEGQGGVGSPLKGVSKKGKMSLKQKIKKEPE---EAGREAPSITLPMVTVPQIPSY 481

  Fly   568 NFNDISCHL-FDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARKQEQQDMENHKLVV- 630
            ..|.|...| |......:..::|||.|||::|:...||......::. .|..||::.:.....|
Mouse   482 RLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQS-QRNAEQREQDEKTSAVK 545

  Fly   631 -------HLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFYKQL---GVLDEMRLEKQQTKQEQ 685
                   .||.||||.|.|..::.:||||.|...|:::.....:|   .||....|:..|.|...
Mouse   546 EELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFTVLLRTTLDLLQEKDSA 610

  Fly   686 Q---QPVM-------------------------------------DLNAVI-------------- 696
            .   :||.                                     |.|.::
Mouse   611 HIFAEPVSLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFH 675

  Fly   697 --------------------------------YANDGPTLYD--RF-YSSVGGQTVP-------- 718
                                            :..:.|.|.|  || :..|....:|
Mouse   676 RAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPRLEDFYRFSWEDVDNILIPENRAHLSP 740

  Fly   719 -AQYQDLKYILEQLMGKLQSGKQG-------------RGRASQSPNKRKQPAKASPNKKLNNGIL 769
             ||.::|...|:.:.....||.:.             |.:.:|.|    .|...|.||.:.||.|
Mouse   741 EAQLKELLEKLDLVSTMRSSGARTRRVRMLRREINALRQKLAQPP----PPQLLSLNKTVPNGEL 801

  Fly   770 SSRTSSPEKTVAGSKVGTTT-----------------SKVRSPPGKNPTGRRASKSSAAA----- 812
            .          |||:..|..                 ||:.:||...|||...|.|...:
Mouse   802 P----------AGSRGDTAVLEQAQQEEPEEEGDRDDSKLPAPPTLEPTGPAPSLSEQESPPDPP 856

  Fly   813 ----ATSTHNKSQFHSNIRSSTTSHSSSGTISSGNSS-----SANG-----TSSSDSSSGSDSGS 863
                .:.:...|:|..:.:...........:..|:..     |.||     .::.||...:..|:
Mouse   857 TLKPISDSKPSSRFLKSRKVEDEELLEKSALQLGSEPLQCLLSDNGIDRLSLTNPDSHPDTPLGT 921

  Fly   864 ESGSSS-----AGSGVSKRKSSSGS--------PLKKQSYARSVEQRQKQRQRRQNEAVAGASAT 915
            ....:|     |.:||..::...|:        |....:...|.|.....|:|
Mouse   922 VGRRTSVLFKKAKNGVKLQRGPDGTLENGEDHGPEDDPASPASTEDEHYSRKR------------ 974

  Fly   916 YPDSRSASSSSDGEDERCRNRQEPERGARRGPIQSKSVPNRSQASRSKPTTEADVG--------E 972
             |.|||.   ||.|.|| ..:||.|.|...|         ..:.:.|...:|..:|        .
Mouse   975 -PRSRSC---SDSEGER-SPQQEEETGVTNG---------FGKHTESGSDSECSLGLSGGLAFEA 1025

  Fly   973 GTGASARRKLSTTTRG---------LAQMDKDADESVSS-------DESEELLPL 1011
            |:|.:..::    :||         |..::.|:|.|.|.       ::..:|.||
Mouse  1026 GSGLTPPKR----SRGKPALSRVPFLEGVNGDSDHSGSGRSLLMPFEDHGDLEPL 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	150/447 (34%)
		EPL1	<250..288	CDD:287484	13/37 (35%)
		PHD_JADE	314..359	CDD:277048	23/44 (52%)
		ePHD_RNO	367..480	CDD:277177	55/117 (47%)
		TFIIA	2138..>2295	CDD:281188
Brpf3	NP_001074784.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..127		9/63 (14%)
		COG5141	117..>603	CDD:227470	165/519 (32%)
		ePHD_BRPF3	269..386	CDD:277173	55/117 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..464		14/77 (18%)
		Bromo_brd1_like	592..689	CDD:99944	9/96 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..879		25/114 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..1015		29/137 (21%)
		BR140_related	1073..1188	CDD:99900	3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850