DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and Kdm4a

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	NP_001155295.1	Gene:	Kdm4a / 230674	MGIID:	2446210	Length:	1064	Species:	Mus musculus

Alignment Length:	715	Identity:	159/715 - (22%)
Similarity:	257/715 - (35%)	Gaps:	206/715 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RRKGRPPNGATT-----AAVAEVTGSGPATGSERVPVLPLCKSKHEEPGAEAGGGGQGRAAAGAT 96
            ::|.....|:|:     ::.:|...|....|.|:..||.:          .:...|.|:||.|..
Mouse   505 KKKSSSSLGSTSSQDSVSSDSETAESVSCQGQEKTGVLTV----------HSYARGDGKAATGEP 559

  Fly    97 STSKSKSTKLAKSASKCKSQGASSSSSWQARSVADIKMSSIYNRSSTEAPAELYRKDLISAMKLP 161
            |..|.:|             ...|.|..:...|||..|.|:.....|:.     |:..:|  |||
Mouse   560 SVKKKRS-------------APRSISEQELAEVADEYMLSLEENKKTKG-----RRQPLS--KLP 604

  Fly   162 DSEPLANYEYLIVTDPWKQEWEKGVQVPVNPDSLPEPCVYVLPEPVVSPAHDFKLP-----KNRY 221
            ...||...|.                     .|..|....:.||........:..|     :||.
Mouse   605 RHHPLVLQEC---------------------GSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRP 648

  Fly   222 LRITKDEHYSPDLHYLTNVVALAENTCAYDIDPIDEAWLRL-YNSDRAQCGAFPINATQFERVIE 285
            .....::.::       .::|.....||  :..|.:.:.:: :.:....||.....|.|.:|...
Mouse   649 PNFEAEKEFN-------EIMAQQAPHCA--VCMIFQTYHQVEFGAFSQSCGDASEPAAQTQRTKP 704

  Fly   286 ELEVRCWEQIQVILKLEEGLGIEFDENVICDVCRSPDSEE--ANEMVFCDNCNICVHQACYGI-T 347
            .:...|:..          .|...|.|:     .:|..||  .:.:|.|..|::.||.:|||: .
Mouse   705 LIPEMCFTT----------TGCSTDINL-----STPYLEEDGTSMLVSCKKCSVRVHASCYGVPP 754

  Fly   348 AIPSGQWLCRTCSM-GIKPDCVLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITK 411
            |..|.:|:|..||. .::.||.||..:|||:: ..:...|.|||||:.|.|.....:....|: .
Mouse   755 AKASEEWMCSRCSANALEEDCCLCSLRGGALQ-RANDDRWVHVSCAVAILEARFVNIAERSPV-D 817

  Fly   412 ISSIPQSRWSLICVLCRKR----VGSCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVK 472
            :|.||..|:.|.||.|:||    .|.|:|||...|.||:||:||...|:.|:        .|...
Mouse   818 VSKIPLPRFKLKCVFCKKRRKRNAGCCVQCSHGRCPTAFHVSCAQAAGVMMQ--------PDDWP 874

  Fly   473 LRSY--CQKHSMSKGKKENAGSHGGGSASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRR 535
            ...:  |.:|     |..|.....|...|:.:..:..:::.:|                    |.
Mouse   875 FVVFITCFRH-----KIPNLERAKGALLSITAGQKVISKHKNG--------------------RF 914

  Fly   536 KNHRKTELTSEERNQARAQRLQEVEAEFDKHVNFND--ISCHLFDVDDDAIVAIYNYWKLKRKSR 598
            .......||:|...:                |||:|  .|.:|:..|   ||           |:
Mouse   915 YQCEVVRLTTETFYE----------------VNFDDGSFSDNLYPED---IV-----------SQ 949

  Fly   599 HNRELIPPKSEDV-------------EMIAR---KQEQQDMENHKLVVHLRQDLERVRNLCYMVS 647
            ...:|.||...:|             :.:|.   :..|.:.|:...:|..|.|   |..|...:.
Mouse   950 DCLQLGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDD---VYTLDEELP 1011

  Fly   648 RREKLSRSLFKLREQVFYKQLGVLDEMRL-----EKQQTKQEQQQPVMDLNAVIYAND--GPTLY 705
            :|.|              .:|.|..:||.     ||:..:::::|.|::..   |..|  .|.||
Mouse  1012 KRVK--------------SRLSVASDMRFNEIFTEKEVKQEKKRQRVINSR---YREDYIEPALY 1059

Fly 706 705
Mouse 1060 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	103/442 (23%)
		EPL1	<250..288	CDD:287484	6/38 (16%)
		PHD_JADE	314..359	CDD:277048	15/47 (32%)
		ePHD_RNO	367..480	CDD:277177	41/118 (35%)
		TFIIA	2138..>2295	CDD:281188
Kdm4a	NP_001155295.1	JmjN	13..55	CDD:128818
		JmjC	175..291	CDD:334913
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..384
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..489
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..537		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..573		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..643		14/80 (18%)
		Interaction with NCOR1. /evidence=ECO:0000250	597..638		11/63 (17%)
		PHD_SF	667..766	CDD:389947	27/115 (23%)
		ePHD_JMJD2A	775..884	CDD:277183	41/118 (35%)
		Tudor_2	902..936	CDD:375553	9/69 (13%)
		Tudor_2	960..994	CDD:375553	4/33 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810