DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and KDM4B

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	XP_005259578.2	Gene:	KDM4B / 23030	HGNCID:	29136	Length:	1130	Species:	Homo sapiens

Alignment Length:	719	Identity:	157/719 - (21%)
Similarity:	249/719 - (34%)	Gaps:	218/719 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QQHHQSHHPPPQQHQRKDVEPQPPPTKRRKGRPPNGATTAAVAEVTG------SGPATGSERVPV 68
            ::..|:..|....|:::....:|.|...:  .|..|...||:.|..|      :||....|
Human   395 RKKEQTKRPGLSSHRKRSQPKKPKPEDPK--FPGEGTAGAALLEEAGGSVKEEAGPEVDPE---- 453

  Fly    69 LPLCKSKHEEPGAEAGGGGQGRAAAGATSTSKSK--STKLAKSASKCKSQG-------------A 118
                 .:.|||....    .||.|.||....:.|  .|| |||..|.||.|             .
Human   454 -----EEEEEPQPLP----HGREAEGAEEDGRGKLRPTK-AKSERKKKSFGLLPPQLPPPPAHFP 508

  Fly   119 SSSSSW------------QARSVADIKMSSIYNRSSTEAPAE----------------------L 149
            |..:.|            ...::.:..:.:..|....|.|:|                      .
Human   509 SEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAA 573

  Fly   150 YRKDLISAMKLPDSEPLANYEYLIVTDP-WKQEWEKGVQVPVNPDSL--PE-------------- 197
            :.::.:|..:.        :|:.....| ||:        ||:|..|  ||
Human   574 FNQEHVSCQQA--------FEHFAQKGPTWKE--------PVSPMELTGPEDGAASSGAGRMETK 622

  Fly   198 --------PCVY--VLPEPVVSPAHDFKLPKNRY-LRITK-----DEHYSP--------DLHYLT 238
                    |..:  :..|...|..|....|..|. |.:.|     ||..||        |...|.
Human   623 ARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALR 687

  Fly   239 NVVAL--AENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEELEVRCWEQIQVILKL 301
            .:::|  .....::..:       |.:|:..|:...:....|.|....:.|:.   |:...|..|
Human   688 PLLSLQWKNRAASFQAE-------RKFNAAAARTEPYCAICTLFYPYCQALQT---EKEAPIASL 742

  Fly   302 EEGLGIEFDEN-------VICDVCRSPDSEE-----ANE---------MVFCDNCNICVHQACYG 345
            .||........       :|.::|.:...|.     ||.         ::.|..|.:.||.:|||
Human   743 GEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYG 807

  Fly   346 I-TAIPSGQWLCRTCSM-GIKPDCVLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEP 408
            | ..:.:..|.|..|:. ....:|.||..:|||::.. :.:.|.||.||:.:||.....|....|
Human   808 IRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMT-TDRRWIHVICAIAVPEARFLNVIERHP 871

  Fly   409 ITKISSIPQSRWSLICVLCRKRV----GSCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAED 469
            : .||:||:.||.|.||.||||:    |:|||||.:.|.|::|||||...|:.|       ..:|
Human   872 V-DISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLM-------EPDD 928

  Fly   470 GVKLRSY-CQKHSMSKGKKENAGSHGG---GSASVASAMQKANRYG-------SGAGG------G 517
            ...:.|. |.||        .:|.|..   .:.|:...:...||.|       .||..      .
Human   929 WPYVVSITCLKH--------KSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVN 985

  Fly   518 ADDGNNACGTTGEDPRRRKNHRKTELTSEE------RNQARAQRLQEVEAEFDKHVNFNDISCHL 576
            .|||:.:           .|.....:||.:      .::.....|:..:....|....:.::.|:
Human   986 FDDGSYS-----------DNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHI 1039

  Fly   577 FDVD 580
            :.|:
Human  1040 YQVE 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	93/381 (24%)
		EPL1	<250..288	CDD:287484	5/37 (14%)
		PHD_JADE	314..359	CDD:277048	15/59 (25%)
		ePHD_RNO	367..480	CDD:277177	46/117 (39%)
		TFIIA	2138..>2295	CDD:281188
KDM4B	XP_005259578.2	JmjN	15..56	CDD:128818
		JmjC	176..292	CDD:202224
		PHD_JMJD2B	717..822	CDD:277051	23/107 (21%)
		ePHD_JMJD2B	831..940	CDD:277184	46/117 (39%)
		TUDOR	955..1007	CDD:197660	11/62 (18%)
		TUDOR	1009..1064	CDD:197660	4/35 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810