DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rno and brpf3a

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	XP_005169382.1	Gene:	brpf3a / 100149254	ZFINID:	ZDB-GENE-130530-730	Length:	1214	Species:	Danio rerio

Alignment Length:	1286	Identity:	295/1286 - (22%)
Similarity:	440/1286 - (34%)	Gaps:	406/1286 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 VQVPVNPDSLPEPCVYVLPEPVVSPAHDFKLPKNRYLRITKDEHYSPDLHYLTNVVALAENTCAY 250
            :|.|     ||:|....|....||.|....:...||:..:.:|               .:|...|
Zfish   146 LQAP-----LPKPTFRKLDNFTVSDAPPLPVAYYRYMEKSGEE---------------LDNEAEY 190

  Fly   251 DIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEELEVRCWEQIQVILKLEEGLG-IEFDENVI 314
            |:|..|.|||.:.|..|...|...:....||.:|:.|     |:..::....:.|. ...||:..
Zfish   191 DMDEEDMAWLEMVNQKRVSDGHASVPPDTFELLIDRL-----ERESILESRSQALSQSTIDEDAY 250

  Fly   315 CDVCRSPDSEEANEMVFCDNCNICVHQACYGITAIPSGQWLCRTC--SMGIKPDCVLCPNKGGAM 377
            |.||...:...:|.::|||.||:.|||.|||:..||.||||||.|  |.....|||||||:|||.
Zfish   251 CCVCLDDECLNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRRCLQSPSRPVDCVLCPNRGGAF 315

  Fly   378 KSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLCR-KRVGSCIQCSVKP 441
            |....|. ||||.||:|||||.......:||:..:.:||.:||.|.|.||: |..|:.|||....
Zfish   316 KQTSDGS-WAHVICAIWIPEVCFANTVFLEPVEGVKNIPPARWKLTCYLCKQKGRGASIQCHKAN 379

  Fly   442 CKTAYHVTCAFQHGLEMRAIIEEGNAEDG----VKLRSYCQKHSM----SKGKKENA-----GSH 493
            |..|:|||||.:.||.|:.........:|    ||..:||:.||.    ::|.::|.     |:.
Zfish   380 CYRAFHVTCAQRAGLYMKIDPVRETGTNGTTFTVKKTAYCENHSPPGTGTEGYEDNGLVGGRGNR 444

  Fly   494 GGGSASVASAMQKANRYGSGAGGGAD----DGNNACGT--TG-------EDPRRRKNHRKTELTS 545
            |..|.::...:|: |:.|...|..|.    ..|:..|:  ||       :.|..|.|...|.::.
Zfish   445 GQRSYTLGPPLQQ-NQNGRKKGSAAQQKKTQKNSGGGSRKTGVPLLLVPQIPSFRLNKICTGVSV 508

  Fly   546 EERNQARAQRLQEVEAEFDKHVNFNDISCHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSED 610
            |.:||. .|||                               :|||.|||.||:...||......
Zfish   509 ERKNQF-MQRL-------------------------------HNYWLLKRHSRNGVPLIRRLHSH 541

  Fly   611 VEMIARKQEQQD--------MENHKLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFYKQ 667
            ::  |:|.||::        .|..|....||||||:.|.|..::.:||:|.|...||::.....|
Zfish   542 LQ--AQKSEQREPDAKLQAVREELKYWQKLRQDLEKARLLIELIRKRERLKREQMKLQQAALELQ 604

  Fly   668 L-GVLDEMRLEKQQTKQEQQQPVMD-----------LNAVIYANDGPTLYDRF----YSS----- 711
            | ..|..:|...:|.|::....:..           |..|....|..|::|:.    |||
Zfish   605 LTPALVFLRATLEQLKEKDTDHIFTTPVNLKEVPDYLEFVTVPMDFSTMHDKLEAHKYSSVADLE 669

  Fly   712 -----------------------------VGGQTV-PAQYQDLKYILEQLMGKLQSGKQGRGRAS 746
                                         |||..: .||:|.|...|:...|
Zfish   670 NDFNLMVSNCLRYNSNDTVFHKAAMQLREVGGAILRHAQHQALSIGLDPSTG------------- 721

  Fly   747 QSPNKRKQPAKASPNKKLNNGILS-----SRTSSPEKTV---AGSKVGTTTSKVRSPPGKNPTGR 803
                 ...|.|..|    :|..:|     .....|:..|   |..::.|...|:........:|.
Zfish   722 -----MHLPDKPIP----HNTTVSWCDEVDMLLDPDNRVHMCAEDQLKTLLDKLDLVASMRTSGG 777

  Fly   804 RASKSSAAAATSTHNKSQFHSNIRSSTTSHSSSGTISSGNSSSANGTSSSDSSSGSDSGSESGSS 868
            |..:...               :|....|.....:....||...||.
Zfish   778 RTKRMRL---------------LRREINSLRHKISHQDRNSRLLNGK------------------ 809

  Fly   869 SAGSGVSKRKSSSGSPLKKQSYARSVEQRQKQRQRRQNEAVAGASATYPDSRSASSSSDGEDERC 933
                 :.:.||......||..|..|.:.::...|:.| |....||:..|.....:
Zfish   810 -----IREEKSKDAKSEKKMDYITSEDPKKSASQKAQ-EPACPASSPLPGDAPPN---------- 858

  Fly   934 RNRQEP----ERGARRGPIQSKSVPNRSQASRSKPTTEADVGEGTGASARRKLSTTTRGLAQMDK 994
                .|    |.|....|.||....:|.|.::.|..:                         :.:
Zfish   859 ----PPLFCLETGRTTTPAQSNKPGSRKQRAKGKDRS-------------------------LRE 894

  Fly   995 DADESVSSDESEELLPLRGERQRESTTTSGLATTGSAIGRNLGQHIYSDSESSSSEQEKDQEEQA 1059
            :.:::...||:                                   :...|:.||    .||::.
Zfish   895 NHNQTPKEDEN-----------------------------------FHTKENDSS----PQEDRV 920

  Fly  1060 TVESNVSDSQNQQT-IRTKAAMKEFVPGTAATTSSTSQAASSTSKAKNTREGKEGAASIGNSTKT 1123
            ....|.|||..... .||....|:...|...|........:..|||:|      ||:...|:...
Zfish   921 CSAKNQSDSPKIGVGRRTSILFKKAKNGARPTKDKPVLLPNGVSKAQN------GASQEQNTQAK 979

  Fly  1124 KPNPNAKLYPADLLVVPQRQAAKKASENMRSTNLATTLQPDVSDRVREPDINSISGTAKSKVKDS 1188
            .|:....:.|              :...:||..|:|                         ..|.
Zfish   980 APSTPKPVSP--------------SPHQLRSRGLST-------------------------CSDG 1005

  Fly  1189 SSRVSNEADKSSLEKVRPKEH-----LQKTVGKTSESAPAERGKRGRPPKVPKDARPPSITENDK 1248
            ....:|..         |:|:     |::..|.:|:|                        ||..
Zfish  1006 EGMKANSL---------PEENGLTNGLKRHNGNSSDS------------------------ENST 1037

  Fly  1249 PALPTHTQSKPPSVVATPVSAKSNFAVSLVPQRQAAKKAAEQLKSSKPVLESFSTGNDISDKETV 1313
            ||.|||:.|.|......|       |:|.||        .::.|:......|.::.|| .:.|.:
Zfish  1038 PAFPTHSSSPPKRSRGKP-------ALSKVP--------VDEEKNEVTNTNSEASQND-GEMEPL 1086

  Fly  1314 TSATISGSG-SSVPAASTPVKPTRRSSIKEA---PITPKEPLS-GRRKSKE 1359
            |.......| .|.||.....|..:...:...   |:.|.:.|. |:|:.:|
Zfish  1087 TLVWAKCRGYPSYPAMIVDPKMPQEGILHNGIPIPVPPTDVLDLGKRRQEE 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	152/451 (34%)
		EPL1	<250..288	CDD:287484	13/37 (35%)
		PHD_JADE	314..359	CDD:277048	23/44 (52%)
		ePHD_RNO	367..480	CDD:277177	52/117 (44%)
		TFIIA	2138..>2295	CDD:281188
brpf3a	XP_005169382.1	EPL1	125..654	CDD:331339	175/568 (31%)
		ePHD_BRPF3	305..422	CDD:277173	52/117 (44%)
		Bromodomain	607..704	CDD:321986	15/96 (16%)
		BR140_related	1084..1198	CDD:99900	13/54 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950