DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rno and jade1

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	NP_001090707.2	Gene:	jade1 / 100036687	XenbaseID:	XB-GENE-949213	Length:	831	Species:	Xenopus tropicalis

Alignment Length:	880	Identity:	312/880 - (35%)
Similarity:	463/880 - (52%)	Gaps:	123/880 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 KSTKLAKSASKCKSQGASSSSSWQARSVADIKMSSIYNRSSTEAPAELYRKDLISAMKLPDSEPL 166
            |.|:|. |:|:......|.|:||...|.:....|.   |.....|:|::|.|||:||||.||..|
Frog     2 KRTRLL-SSSEDSDNNDSLSTSWSQHSRSRPSGSL---RHEDRKPSEVFRTDLITAMKLHDSYQL 62

  Fly   167 ANYEYLIVTDPWKQEWEKGVQVPVNPDSLPEPCVYVLPE--PVVSPAHDFKLPKNRYLRITKDEH 229
            ...::.::.|||:|||||||||||||:.:||.....:.|  .||:    |..|: :|:|.:..|
Frog    63 NPEDFYVLADPWRQEWEKGVQVPVNPEFIPETVAREIAEKDKVVT----FTRPR-KYIRSSGSE- 121

  Fly   230 YSPDLHYLTNVVALAENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEELEVRCWEQ 294
             .|:|.|: ::..||:..|.||:|.:|.|||.|.|.:..:.|...::....|||:||.|.:|:::
Frog   122 -PPELGYV-DIQTLADAVCRYDLDEMDVAWLELINEEFKEMGMQQLDEYSMERVLEEFEKKCYDK 184

  Fly   295 IQVILKLEEGLGIEFDENVICDVCRSPDSEEANEMVFCDNCNICVHQACYGITAIPSGQWLCRTC 359
            :...::.|||||||:||:|:||||:|||.|:.|||||||.||||||||||||..:|.|.||||||
Frog   185 MNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTC 249

  Fly   360 SMGIKPDCVLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLIC 424
            ::|::|.|:|||.||||||..:||..|.||||||||||||||..::||||||:|.||.|||:|.|
Frog   250 ALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALFC 314

  Fly   425 VLCRKRVGSCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDGVKLRSYCQKHSMSKGKKEN 489
            .||.:::|:|||||:|.|:||:||||||.|||||:.|:.|   ||.||.:|||.||..:| |.||
Frog   315 SLCNEKLGACIQCSIKNCRTAFHVTCAFDHGLEMKTILTE---EDEVKFKSYCPKHGSTK-KPEN 375

  Fly   490 AGSHGGGSASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNHRKTELTSEE--RNQAR 552
              ||...|                    .:||...||.:   |......|..:::.::  ....|
Frog   376 --SHFCKS--------------------VNDGKGTCGAS---PTCLDGLRLLDVSQQDAKHGSQR 415

  Fly   553 AQRLQEVEAEFDKHVNFNDISCHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARK 617
            ..:||::|.||...|:..:|| ....:..|....||.||||:||:..|..||.||.::.:.:|:|
Frog   416 KFKLQQLEDEFHTFVDVQEIS-QALKIPLDMTEYIYQYWKLRRKANFNEPLITPKKDEEDNLAKK 479

  Fly   618 QEQQDMENHKLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVF---------YKQLGV-LD 672
            ::...:...:|..||||||||||||.|||:||||:.||:.:::||:|         .|.||. |:
Frog   480 EQDVLIRRLQLFTHLRQDLERVRNLTYMVTRREKMKRSVCRVQEQIFNLYAKISEQEKNLGFPLE 544

  Fly   673 EMRLEKQQTKQEQQQPVMDL---NAVIYANDGPTL-------YDRFYSSVGGQTV---------- 717
            .:.|...|........:.||   :|......|.||       :.:....:.|:::
Frog   545 SVLLFNTQPSDPDAPKIEDLKWHSAFFRKQLGSTLGCSMKDSHKKSRVRIMGKSLDTEILLPERK 609

  Fly   718 -PAQYQDLKYILEQLMGKLQSGKQGRGRASQSPNKRKQP-AKASPNKKLNNGILSSRTSSPEKTV 780
             ..|..|:.:..|:.:.|::..:|..|.:.....||:.. |:..|.|      .|.:...|.:.
Frog   610 KEGQTSDVSFSFEKTVAKIRPVQQKNGASMPEHRKRRDSRAQGDPAK------FSLKEKPPRQQ- 667

  Fly   781 AGSKVGTTTSKVRSPPGKNPTGRRA-SKSSAAAATSTHNKSQFHSNIRSSTTS----HSSSGTIS 840
                  ...:|...||.:....:|. |:..:..||::.||.|..|::...:.|    |....::.
Frog   668 ------HRPAKPAEPPERPAENKRVLSQCGSKTATTSANKKQCSSSLPRYSGSLIKLHCKQSSVK 726

  Fly   841 SGNSSSANGTSSSDSSSGSDSGSESGSSSAGSGVSKRKSSSGSPLKKQSYARSV------EQRQK 899
            ...|...|.                    .|..:.|:......|...::...::      :..:|
Frog   727 VPTSPVKNW--------------------GGFRIPKKGERQQQPGNMETCQPNLNCQFLGQVSKK 771

  Fly   900 QRQRRQNEAVAGASATYPDSRSASSSSDGEDERCR 934
            :|.:.:::..:......||:..:.|.|:..| :||
Frog   772 ERTKEKHKLYSENDGYTPDAEMSDSESEPTD-KCR 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	201/415 (48%)
		EPL1	<250..288	CDD:287484	15/37 (41%)
		PHD_JADE	314..359	CDD:277048	33/44 (75%)
		ePHD_RNO	367..480	CDD:277177	73/112 (65%)
		TFIIA	2138..>2295	CDD:281188
jade1	NP_001090707.2	EPL1	<79..179	CDD:371106	41/107 (38%)
		COG5141	140..>528	CDD:227470	202/417 (48%)
		ePHD_JADE	257..367	CDD:277141	73/112 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3619
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001581
OrthoInspector	1	1.000	-	-		otm48779
Panther	1	1.100	-	-	LDO	PTHR13793
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.130