DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rno and brd1b

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	XP_005163199.1	Gene:	brd1b / 100009661	ZFINID:	ZDB-GENE-070209-98	Length:	1168	Species:	Danio rerio

Alignment Length:	1368	Identity:	292/1368 - (21%)
Similarity:	468/1368 - (34%)	Gaps:	457/1368 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LAKSASKCKSQGASSSSSWQARSVADIKMSSIYNRSSTEAPAELYRKDLISAMKLPD-----SEP 165
            ||:..|:|.|                       |:.:||.|.::    |:.:::|.:     |..
Zfish    64 LAQEISECTS-----------------------NKENTEKPQQV----LVRSVRLKNNQQKKSAA 101

  Fly   166 LANYEYLIVTDPWKQEWEKGVQVPVNPDSLPEPCV----YVLPEPVVSPAHDFKLPKNRYLRITK 226
            |.|                 ||.......||||.:    |.||.....|:..:     .|:..|.
Zfish   102 LTN-----------------VQGSPAQGRLPEPKIRMVEYNLPAVPRRPSVYY-----TYMEKTL 144

  Fly   227 DEHYSPDLHYLTNVVALAENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEELEVRC 291
            ||               .:....||:|..|.|||.:.|..|...|...::...||.:::..|...
Zfish   145 DE---------------LDEEVEYDMDEEDYAWLEMMNEKRKSDGHSQVSQNVFEFLMDRFEKES 194

  Fly   292 WEQIQVILKLEEGLGIEFDENVICDVCRSPDSEEANEMVFCDNCNICVHQACYGITAIPSGQWLC 356
            :...|...:.:..:    ||:.:|.:|...:.:.:|.::|||.||:.|||.|||:..||.|:|||
Zfish   195 FFDSQAQGEPQSLI----DEDAVCCICMDGECQNSNAILFCDMCNLAVHQECYGVPHIPEGRWLC 255

  Fly   357 RTC--SMGIKPDCVLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSR 419
            |.|  |.....:|:.|||||||:|.....: |.||.||:|:|||.......:|||..:::||.:|
Zfish   256 RHCLNSPSQLAECIFCPNKGGALKRTDDDR-WGHVVCAIWVPEVGFTNTLFIEPIDGVANIPPAR 319

  Fly   420 WSLICVLCRKR-VGSCIQCSVKPCKTAYHVTCAFQHGLEM-----RAIIEEGNAEDGVKLRSYCQ 478
            |.|.|.||:|: ||:|||||...|.||:||:||.:.||.|     :.:.|.|.....||..:||.
Zfish   320 WKLTCYLCKKKGVGACIQCSKANCYTAFHVSCAQKAGLYMKMEPVKEVTESGGTTFSVKKTAYCC 384

  Fly   479 KHSM-------------SKGKKENAGSHGGGSASVASAMQKANRYGSGAGGGADDGNNACGTTGE 530
            .|:.             ||.|                                   |..|
Zfish   385 PHTPNGFVRRPLTIYDDSKSK-----------------------------------NGVC----- 409

  Fly   531 DPRRRKNHRKTELTSEERNQARAQRLQEVEAEFDKHV-----------NFNDI-------SCHLF 577
               ::..||      |.....:.::.::.|:|.|..|           :||.|       ...:|
Zfish   410 ---QKAAHR------ERVKGCQKKKNKKPESEPDTVVPTVSGPSITPKSFNTILNQVSVQKKRMF 465

  Fly   578 DVDDDAIVAIYNYWKLKRKSRHNRELIPPKSEDVEMIARKQEQQDMENHKLVV-------HLRQD 635
                  :..:.:||.|||:||:...||......::.....::...:::|:.:.       .||.|
Zfish   466 ------VERVLSYWMLKRQSRNGVPLIRRLQTAIQTQKDPEDDPCVDDHQTLTDQLKDLHRLRHD 524

  Fly   636 LERVRNLCYMVSRREKLSRSLFKLREQVFYKQL---GVLDEMRLEKQQTKQEQQ---QPVM---- 690
            |||.|.|..::.:||||.|...||::.|...||   .::..:.|::.|.|.:.:   |||.
Zfish   525 LERARLLLELIRKREKLKREEMKLQQSVLEMQLTPFPIILRVALDQLQEKDQAKIFAQPVSVTEV 589

  Fly   691 --DLNAVIYANDGPTLYDRFYSSVGGQTVPAQYQDLKYILEQLMGKLQSGKQGRGRASQSPNKRK 753
              .|:.:.:..|..|:..|    :.|.    :||.|....|.....:.             |..|
Zfish   590 PDYLDHIKHPMDFSTMRKR----IDGH----EYQSLDEFEEDFNLIIN-------------NCLK 633

  Fly   754 QPAK------ASPNKKLNNGILSSRTSSPEKTVAGSKVG---------TTTSKVRSPPGKNPTGR 803
            ..||      |....:.:.|::..||....:     ::|         ....|:..||
Zfish   634 YNAKDTYFYRAGVRMRDHGGVILRRTRRETE-----RIGFEFPSGIHLPEPPKLELPP------- 686

  Fly   804 RASKSSAAAATSTHNKSQFHSNIRSSTTSHSSSGTISSGNSSSANGTSSSDSSSGSDSGSESGSS 868
                                     |.|.|.....::..|
Zfish   687 -------------------------SFTWHDVDRVLNPAN------------------------- 701

  Fly   869 SAGSGVSKRKSSSGSPLKK------QSYA-RSVEQRQKQRQRRQNEAVAG-----ASATYPDSRS 921
                   :...|....|||      .::| :|...|.| |.:...:.:..     ...|.|.|..
Zfish   702 -------RAHMSKDEQLKKLLEMLDLTFAMKSCPSRSK-RLKLLKKTIGDVRMDMGQKTEPPSLE 758

  Fly   922 ASSSSDGEDERCRNRQEPERGARRGPIQSKSVPNRSQASRSKPTTEADVGEGTGASARRKLSTTT 986
            .:::.:.|.......||.|        ..||:|.:.:.|.|.|.
Zfish   759 QNNTKEEEKAPLILPQEEE--------GDKSLPPKLEPSDSVPL--------------------- 794

  Fly   987 RGLAQMDKDADESV--SSDESEELLPLRGERQRESTTTSGLATTGSAIGRNLGQHIYSDSESSSS 1049
              |...|...:...  ..:.|.|..|.:.:...|:.:||.|                   ...|.
Zfish   795 --LKNSDSPCEPPTLKPMEPSPEKCPKKVKFDGETFSTSLL-------------------NGLSP 838

  Fly  1050 EQEKDQEEQATVESNVSDSQNQQTIRTKAAMKEFVPGTAATTSSTSQAASSTSKAKNTREGKEGA 1114
            :....:.......|.:::..|....||....::             ...:|..|..||.|.....
Zfish   839 DVLPSENNVMVATSTLTEPANIVNRRTAVLFRK-------------SKNTSPQKLLNTSEPSIDC 890

  Fly  1115 ASIGNSTKTKPNPNAKLYPADLLVVPQRQAAKKASENMRSTNLATTLQPDVSDRVREPDINSISG 1179
            ..:|..|...            :|:|:.:.   ..::.:.|:.|:...||..|
Zfish   891 PQLGTKTFLS------------VVIPRLET---LLQHRKRTHSASGDSPDEED------------ 928

  Fly  1180 TAKSKVKDSSSRVSN--EADKSSLEKVRPKEHLQKTVGKTSESAPAERGKRGRPPKVPKDARPPS 1242
              :..:|...:.:||  ...|..:...||.|..::.   .|||:.:..|.             .|
Zfish   929 --ECPIKRLDTGLSNGFSEPKKGIIVTRPSEPRRRC---ASESSISSSGS-------------GS 975

  Fly  1243 ITENDKPALPTHTQSKPPSVVATPVSAKSNFAVSLVPQRQAAKKAAEQLKSSKPVLESFSTGNDI 1307
            |.||....  :||:           |.|...|::   :|.......|.|..::|       || |
Zfish   976 IQENSSDV--SHTK-----------SGKGKLAMA---RRNTTDDKKELLNCTEP-------GN-I 1016

  Fly  1308 SDKETVTSATISGSGSSVPAASTP--VKP-----TRRSSIKEAP---ITPKEPLSGRRKSKEDLL 1362
            | |....:|.|..|...:||.:||  ::|     .:.|.....|   |.|:.|..|...: |:.:
Zfish  1017 S-KANKLAAEIDSSNIWMPANTTPLNLEPLKVVWAKLSGYPSYPALIIDPQLPRVGCHLN-EEYI 1079

  Fly  1363 ATP 1365
            .||
Zfish  1080 PTP 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	134/459 (29%)
		EPL1	<250..288	CDD:287484	12/37 (32%)
		PHD_JADE	314..359	CDD:277048	21/44 (48%)
		ePHD_RNO	367..480	CDD:277177	53/118 (45%)
		TFIIA	2138..>2295	CDD:281188
brd1b	XP_005163199.1	EPL1	45..193	CDD:287484	41/192 (21%)
		PHD_BRPF2	211..264	CDD:277147	23/52 (44%)
		PHD_SF	268..386	CDD:304600	53/118 (45%)
		Bromo_brd1_like	559..656	CDD:99944	21/117 (18%)
		PWWP	1042..1157	CDD:295359	10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850