Protein Alignment rno and kdm4aa

DIOPT Version :9

• Sequence 1: NP_001246528.1
• Gene: rno / 38027
• FlyBaseID: FBgn0035106
• Length: 3241
• Species: Drosophila melanogaster
• Sequence 2: XP_001921829.2
• Gene: kdm4aa / 100003413
• ZFINID: ZDB-GENE-110609-4
• Length: 2012
• Species: Danio rerio
• Alignment Length: 1765
• Identity: 313/1765 - (17%)
• Similarity: 631/1765 - (35%)
• Gaps: 441/1765 - (24%)

  Fly   488 ENAGSHGGGSASVASAMQ-KANR-YGSGAGGGADDGNN----------ACGTTG--------EDP 532
            |:.|:|..|.|.|..... |..| |        ||..:          ..|.:|        :.|
Zfish    38 ESQGAHRAGMAKVVPPKDWKPRRTY--------DDIEDLVIPTPIQQVVTGQSGLFTQYNIQKKP 94

  Fly   533 RRRKNHRKTELTSEERNQARAQRLQEVEAEFDKHVNFN------DISCHLFDVDDDAIVAIYNYW 591
            ...:..|||..|.:..|...|. .:|:|.:|.|::.||      |:|..|:|.|    |..:|..
Zfish    95 MTVREFRKTANTDKFSNPRYAD-FEELERKFWKNLTFNPPLYGADVSGTLYDPD----VMEWNIG 154

  Fly   592 KLKRKSRHNRELIPPKSEDVEMIARKQ-----------------------EQQDMENHKL-VVHL 632
            :|              :..::|:.|:.                       ..:||:.:.: .:|.
Zfish   155 RL--------------NTILDMVERESGITIKGVNTPYLYFGMWKSTFAWHTEDMDLYSINYLHF 205

  Fly   633 RQDLERVRNLCYMV-----SRREKLSRSLFK---------LREQVFYKQLGVLDEMRLEKQQTKQ 683
            .:.     ...|:|     .|.|:|::..|.         ||.::......:|.:..:..::..|
Zfish   206 GEP-----KSWYVVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPSILRKYGIPFEKVTQ 265

  Fly   684 EQQQPVMDLNAVIYANDGPTLYDRFYSSVGGQTVPAQYQDLKYILEQLMGKLQSGKQGRGRASQS 748
            |..|.::                         |.|..|              .:|.......::|
Zfish   266 EAGQFIV-------------------------TFPYGY--------------HAGFNHGFNCAES 291

  Fly   749 PNKRKQPAKASPNKKLNNGILSSRTSSPEKTVAGSKVGTTTSKVRSPP--------GKN--PTGR 803
            .|...|       :.::.|.|::..|..:..|   |:.......:..|        ||:  |...
Zfish   292 TNFATQ-------RWIDYGKLATLCSCRKDMV---KISMDVFVHKFQPERYKLWKAGKDNVPIDH 346

  Fly   804 RASKSSAAAATSTHNKSQFHSNIRSSTTSHSSSGTISSGNSSSANGTSSSDSSSGSDSGSESGSS 868
            .......|.....:.|.:...:.|:.|.  ...|...:|:...||          :|.|.|..:.
Zfish   347 SKPTPEVAEIQKENEKGEISDSERAETL--EERGEAEAGDQQKAN----------TDDGEEDKAE 399

  Fly   869 SAGSGVSKRKSSSGSPLKKQSYARSVEQRQKQRQRRQNEAVAGASATYPDSRSASSSSDGEDE-- 931
            :....|.||:|.:|....:....:||...:......|..:.:....|......:|:.::.:|:
Zfish   400 AFSEKVVKRESDAGKEKAEAEVEKSVRDEEPSSTSEQISSSSPKQNTGQKRLRSSTDNEAKDDNQ 464

  Fly   932 -RCRNRQEPERGARRGPIQSKSVPNRSQASRSKPTTEADVGEGTGASARRKLSTTTRGLAQMD-- 993
             :....:..::.|:.|  |:::..|..|:..::|..|         .|...:.|.|....|.:
Zfish   465 VKIEVEEVEKKKAKLG--QNETDNNEEQSVSAEPDDE---------KAEETMETDTPPPQQQECM 518

  Fly   994 ----KDADESVSSDESEELLPLRGERQRESTTTSGLATTGSAIGRN--LGQHIYSDSESSSSEQE 1052
                ..:|.:.|||.:.:      :|:.||:..:....:.:::..:  ||..:.|.||
Zfish   519 EAELSTSDPTSSSDITTQ------QREEESSDVTSSTQSINSVDEDVALGGDVASQSE------- 570

  Fly  1053 KDQEEQATVESNVSD------SQNQQTIRTKAAMKEFVPGTAATTSSTSQAASSTSKAKNTREGK 1111
             |..:...|:.|..|      :..|.:..|.......:|.|:..:.|:|..:..:.....|.:|.
Zfish   571 -DVTQSFVVQINPEDITPTDLTDAQPSNITSHPCSSDIPATSFMSVSSSNFSKHSISFAYTCDGT 634

  Fly  1112 EGAASIGNSTKTKPNPN------AKLYPADLLVVPQRQAAKKASENMRSTNLATTLQPDVSDRVR 1170
            ...:...|.|...|:.|      .:..|:|::|      :.|.:.:..|| ..:.:|.|:|:...
Zfish   635 TEPSDSINLTPRVPSINVAHISDVQPEPSDIIV------SLKQNSSANST-YTSDVQSDLSNVTV 692

  Fly  1171 EPDIN-SISGTAKSKVKDSSSR--VSNEADKSSLEKVRPKEHLQKTVGKTSESAPAERGKRGRPP 1232
            :|:.. ||:.|....|:..:|.  :|:|.:.|          :..|.....:|..:.:.:.|...
Zfish   693 DPEHKPSINSTHIINVQSETSNITISSEHEPS----------ISSTPMSDVQSETSFKYEPGNNS 747

  Fly  1233 KVPKDARPPSITENDKPALPTHTQSKPPSVVATPVSAKSNFAVSLVPQRQAAKKAAEQLKSSKPV 1297
            ....|.:|   ..:|....|.:    .|.|         |||.:...|.:.::  .|...:|..:
Zfish   748 AYVCDVKP---EHSDISMSPIY----KPGV---------NFAHTSDVQPEPSE--CESCTNSDHI 794

  Fly  1298 LESFSTGNDI----SDKETVTSA------------TI---------SGSGSSVPAASTPV----- 1332
            .:..|..|||    .|:.::.||            |:         |.|||.||:....:
Zfish   795 CDVQSEANDIIINSKDEMSINSAHTFDVQPEPSDNTVSLTHKPDISSTSGSDVPSGPGDITDSLG 859

  Fly  1333 -----KPTRRSSIK-EAPITPKEPLSGRRKSKEDLLATPIKTTP--LVKRRVVVPNLSSSSSGDS 1389
                 ..|....:: |:..:||..|........|:.:.|...|.  ..:......::....||.|
Zfish   860 YDPDFNSTHTGHVQSESNNSPKHKLPINSAHTYDVQSGPSDITDGHRFESEFNSTHICDVQSGPS 924

  Fly  1390 ESSSSSSSSGSSSSSGGSDSDSESQASNSENPSSREPPVAPAKV------PSDSSLVPKRSPRKS 1448
            :.|.:|....|..|:  ...|::|..|:....|.:|..:..|::      |||.|:..|:....:
Zfish   925 DMSVNSKRKSSIDSA--QIDDAQSDPSDISIGSKQEYSINSAQIDNVQSEPSDISIGSKQESSIN 987

  Fly  1449 MDKPSALTIAPASVNVLNIPSTRSRQNSTTKSTKVALQKAVQSVEDDVKCTPKTNRLQGSMDECG 1513
            ..:...:...|:::::      .|:|.::..||::   ..|||...|:..:.| |:|:.:
Zfish   988 SAQIDNVQSEPSNISI------SSKQETSINSTQI---DDVQSEPSDISISSK-NKLRIN----- 1037

  Fly  1514 KQVQLEQATKRATRGSKSRPPSPTAKSSPEKTVSRCKSRAEESPKKVANLEQEISQRKVASGKGT 1578
             ..|::..         ...||..:.||.::| |...::.::...:.:::  .||.:...|...|
Zfish  1038 -SAQIDDV---------QSAPSGISVSSEQET-SIISAQVDDVQSEYSDI--SISSKHEPSINST 1089

  Fly  1579 SS-------LDKLLNKKQQQMNHSA-----QATPPPISPTPPASETRIVKDQ---CDLKPDEVSI 1628
            .:       :|.....||:...:||     |:.|..|| .....||.|...|   ..|:|.::||
Zfish  1090 QTDDIQSEPIDISFGSKQESCINSAQMYDVQSEPSDIS-ISSTQETSINSAQMYDVQLEPSDISI 1153

  Fly  1629 Q-----QINLGA--DAQPEP-DL----DPESAAEAGELPMDIDEELT--TAPTRTQLSASASKLA 1679
            .     .||...  |.|.|| |:    :.|:...:.:: .|:..|.:  :..::.:.|.:::::.
Zfish  1154 SFKDKPSINSSQVDDVQSEPSDICFGSEQETCINSAQI-YDVQSEPSNISFSSKQETSINSTQMY 1217

  Fly  1680 DIIDDERPPAAPLPASPTPTPTSNDEMSDAGSD-----LSERRRMRWRSRRRRRRRSHEPDEEHT 1739
            |:   :..|:....:|...|..::.:|.|..|:     :|..:.....|.:....:|...|...:
Zfish  1218 DV---QSEPSDISISSNQETSINSTQMYDVQSEPSDISISSNQETSINSTQMYDVQSEPSDISIS 1279

  Fly  1740 HHTQHLLNEMEMARELEEERKNELLANASKYSASTSSPAVTVIPPDPPEIIELDSNSAEQQQQHL 1804
            .:.:..:|..:| .:::.|..:  ::.:|....:.:|..:..:..||.:|.....:........:
Zfish  1280 SNQETSINSTQM-HDVQSEPSD--ISISSNQETTINSTQMYDVQSDPSDISISSKHKPSINSARM 1341

  Fly  1805 HDQPLPPPLVVQSPAADVV------PTVMQQQLLPSQ-RPLIEQLPVEHLPIVET--ILEMEDS- 1859
            :|        |||..:|:.      |::...|:...| .|....:..:|.|.:::  |.:::.:
Zfish  1342 YD--------VQSEPSDISISSKHNPSIDSTQMFDVQSEPSDFSISSKHKPSIDSTQIYDVQSAP 1398

  Fly  1860 ---------KFANNFASNLASVLNPPNQMSLIGS---SIDRSKQISEEDSIQATRNLLEKLRKTK 1912
                     |.:.| ::.:..|.:.|:..|:...   ||| |..:.::..::::..::.:..:..
Zfish  1399 SGLTISYKQKTSIN-SAQMYEVQSEPSDFSVSSKRKPSID-SIHMYDDVQLKSSNFMVSRTPEPT 1461

  Fly  1913 RKAQDDCSSKEAVDLLPPTPAIPSVFP------FHNAADPEDIIH-------------------- 1951
            .|...:.||..:|::...:..:.||..      |.....|.:::|
Zfish  1462 YKIIPEPSSSVSVNVSGLSSVLASVSQGSVQHIFQRTLSPAEVLHVHSYAKGDYSDIEPRIQHER 1526

  Fly  1952 ---AQKEQQHQQQQQLQSSQTCIYGNSSGP-------NSVASLTIKDSPMTANSG----SYANSL 2002
               :..|.|...:::.:......|.....|       :|::...::|...:...|    ::|..|
Zfish  1527 DSDSDSESQDDNKKEAERPAEAQYRLPRLPRHHPLIKDSISDEELQDQAASEEDGLDGEAWARPL 1591

  Fly  2003 TNTPNATPTN 2012
            |......|.|
Zfish  1592 TQLWQNRPYN 1601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	47/239 (20%)
		EPL1	<250..288	CDD:287484
		PHD_JADE	314..359	CDD:277048
		ePHD_RNO	367..480	CDD:277177
		TFIIA	2138..>2295	CDD:281188
kdm4aa	XP_001921829.2	JmjN	16..58	CDD:128818	6/19 (32%)
		JmjC	178..294	CDD:202224	20/159 (13%)
		PHD_SF	1618..1714	CDD:304600
		PHD_SF	1723..1832	CDD:304600
		TUDOR	1847..1902	CDD:197660
		TUDOR	1904..1959	CDD:197660

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900