DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rno and brpf3b

DIOPT Version :9

Sequence 1:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster
Sequence 2:	XP_005166793.1	Gene:	brpf3b / 100003354	ZFINID:	ZDB-GENE-081104-468	Length:	1222	Species:	Danio rerio

Alignment Length:	1384	Identity:	318/1384 - (22%)
Similarity:	487/1384 - (35%)	Gaps:	417/1384 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 GAEAGGGGQGRAAAGATSTSKSKSTKLAKSASKCKSQGASSSSSWQARSVADIKMSSIYNRSSTE 144
            ||::.....|.||...:........:|..|.::      .:.:..||:.:.::.:....:|.|..
Zfish    12 GAQSDASDTGTAAVEDSQPRSPSPYRLKVSPTR------ETLTYAQAQKIVEVDLDGRLHRISIF 70

  Fly   145 APAELYRKDLISAMKLPDSEPLANYE-------YLIVTDPWKQEWEKGVQVPV------------ 190
            .|..:..:|.::|..:  :|..:|.|       ..:|:.|.:....:|.:..|
Zfish    71 DPLVVITEDEMTAQDI--AECNSNKENSEQTSVSTVVSSPRRSVANRGKKKDVKQLSSSQNHCSN 133

  Fly   191 -------------NPDSLPEPCV--YVLPEPVVSPAHDFKLPKNRYLRITKDEHYSPDLHYLTNV 240
                         :..:||:|..  :...|||.:|..    |...|..|.|... .||
Zfish   134 SHGQSQTQSSGNSHHGTLPKPTFKEHEFYEPVEAPPR----PSAYYRYIDKSSE-DPD------- 186

  Fly   241 VALAENTCAYDIDPIDEAWLRLYNSDRAQCGAFPINATQFERVIEE------LEVRCWEQIQVIL 299
                 ....||:|..|.|||.|.|..|...|...|:...||.:|:.      ||.|.....|.::
Zfish   187 -----TDAEYDMDEEDVAWLELVNEKRDSDGQPHISPDTFELLIDRLEKESFLESRSQASSQSVI 246

  Fly   300 KLEEGLGIEFDENVICDVCRSPDSEEANEMVFCDNCNICVHQACYGITAIPSGQWLCRTC--SMG 362
                      ||:..|.||...:...:|.::|||.||:.|||.|||:..||.||||||.|  |..
Zfish   247 ----------DEDAFCCVCLDDECLNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPS 301

  Fly   363 IKPDCVLCPNKGGAMKSNKSGKHWAHVSCALWIPEVSIGCVDRMEPITKISSIPQSRWSLICVLC 427
            ...|||||||:|||.|....|: ||||.||:|||||.......:|||..:.:||.:||.|.|.||
Zfish   302 RPVDCVLCPNRGGAFKQTSDGR-WAHVVCAIWIPEVCFANTVFLEPIEGVDNIPPARWKLTCYLC 365

  Fly   428 R-KRVGSCIQCSVKPCKTAYHVTCAFQHGLEMRAIIEEGNAEDG----VKLRSYCQKHS--MSKG 485
            : |..|:.|||....|.||:|||||.:.||.|:.........:|    ||..::|:.||  ::..
Zfish   366 KQKGCGASIQCHKANCYTAFHVTCAQRAGLFMKIDPVRETTVNGTTFSVKKTAFCEAHSPAVNGS 430

  Fly   486 KKENAGSHGGGSASVASAMQKANRYGSGAGGGADDGNNACGTTGEDPRRRKNHRKTELTSEERN- 549
            ..|..|....|.        :||| |..|.....:.....|:...|.::.:...|.|..|::..
Zfish   431 DDEETGGRVLGC--------RANR-GRSAYMQTPELKKQKGSNKVDSKQPQKKGKKEEVSKKTTT 486

  Fly   550 ------QARAQRLQEVEAEFDKHVNFNDISCHLFDVDDDAIVAIYNYWKLKRKSRHNRELIPPKS 608
                  :..||||.::..:.            :....:..:..::|||.|||:||:...||....
Zfish   487 LLVTVPEIPAQRLNKISKDV------------IIQKKNQFMQRLHNYWLLKRQSRNGVPLIRRLH 539

  Fly   609 EDVEMIARKQEQQD--------MENHKLVVHLRQDLERVRNLCYMVSRREKLSRSLFKLREQVFY 665
            ..::. .|..||.:        .|..|....||.||||.|.|..::.:||||.|...|:.:.|..
Zfish   540 SHLQG-QRSAEQAEPDEKLNAVREELKYWQKLRHDLERARLLIELIRKREKLKREQVKIHQAVTE 603

  Fly   666 KQLG---VLDEMRLEKQQTKQEQQ---QPV---------------MDL----------------- 692
            .||.   ||....||:.|.|...:   |||               ||.
Zfish   604 HQLTPVLVLLSSTLEQLQEKDTAKIFAQPVNLKEVPDYLEFITHPMDFSTMQSKLEAHKYRSVTD 668

  Fly   693 ----------NAVIYANDGPTLYDRFYSS------VGG---QTVPAQYQDLKYILEQLMGKLQSG 738
                      |.::| |...|:   ||.:      :||   :....|.|:..:.|:..|
Zfish   669 LEADFNLMISNCLLY-NAKDTV---FYQAAIRLRDLGGAILRHAQRQAQNTGFDLDTGM------ 723

  Fly   739 KQGRGRASQSPNKRKQ--------PAKASPNKKLNNGILSSRTSSPEKTVAGSKVGTTTSKVRSP 795
                 ..::||||...        .....|:.:|:      .|:..:......|:...|| :||.
Zfish   724 -----HLAESPNKNDYYRCTFEDVDTLLDPDNRLH------MTTENQLRELLEKLDVVTS-MRSS 776

  Fly   796 PGKNPTGRRASKSSAAAATSTHNKSQFHSNIRSSTTSHSSSGTISSGNSSSANGTSSSDSSSGSD 860
            ..:....|...:..        ||.:|..|::               ||...||    |.....|
Zfish   777 GARTRRVRLLRREI--------NKVRFKQNLK---------------NSHMLNG----DLKEDDD 814

  Fly   861 SGSESGSSSAGSGVSKRKSSSGSPLKKQSYARSVEQRQKQRQRRQNEAVAGASATYPDSRSASSS 925
            ...|.....|                                               |...:|||
Zfish   815 EDDEDKEMDA-----------------------------------------------DHNLSSSS 832

  Fly   926 SDGEDERCRNRQEPERGARRGPIQSKSVPNRSQASRSKPTTEADVGEGTGASA---RRKLSTTTR 987
            ||.:|  |::...|    ...|......|......:..||......:...:|.   |.||::..:
Zfish   833 SDKDD--CKSTPPP----MLEPTGLALSPPPGDTPQEPPTLRPMTSDPRTSSCPPKRLKLNSERQ 891

  Fly   988 GLAQMDKDADESVSSDESEELLPLRGERQRESTTTSGLATTGS-------AIGRNLGQHIYSDSE 1045
               ::|.|.....|..:.|:..|       |....:||::|.|       .:||...........
Zfish   892 ---ELDSDPTPMNSCTKLEDAPP-------EIKLFNGLSSTESPSRPNTGGVGRRTSVLFKKAKN 946

  Fly  1046 SSSSEQEKDQEEQATVESNVSDSQNQQTIRTKAAMKEFVPGTAATTSSTSQAASSTSKAKNTREG 1110
            .:..::|:|.:.|   ..|..|....:|....|.:|         |.:|:|...||
Zfish   947 GAKLQRERDNQMQ---NGNREDGDAARTHNCTATVK---------TETTAQPKPST--------- 990

  Fly  1111 KEGAASIGNSTKTKPNPNAKLYPADLLVVPQRQAAK--KASENMRSTNLATTLQPDVSDRVRE-- 1171
                          |.|         :.||.:|..:  ..|.....|....||:|.:::..|:
Zfish   991 --------------PPP---------ISVPAKQQTRSHSCSPERERTPPRLTLEPALTNGFRKHK 1032

  Fly  1172 -----------PDINS-ISGTAKSKVKDSSSR------VSNEADKSSLEKVRPKEHLQKTVGKTS 1218
                       |.:.. ||...||:.|.:.|:      |:.::|.:..:.:        :.|.|.
Zfish  1033 DGGSDSECSSSPTLRELISPPKKSRGKPALSKVPFLETVNGDSDYTGTDVL--------SNGDTP 1089

  Fly  1219 ESAPAE---RGKRGRP--------PKVPKDARPPSITENDKPALPTHTQSKPPSVVATPVSAKSN 1272
            |..|.:   ...||.|        |.:|:|    .:..|..| :|.     ||..|
Zfish  1090 EPEPLDLVWAKSRGYPSYPALIIDPDMPQD----GLLHNGVP-IPV-----PPLDV--------- 1135

  Fly  1273 FAVSLVPQRQAAKKAAEQL 1291
              :.|..|||  ::|.|:|
Zfish  1136 --LRLGEQRQ--EEAGERL 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rno	NP_001246528.1	COG5141	250..>664	CDD:227470	148/443 (33%)
		EPL1	<250..288	CDD:287484	15/43 (35%)
		PHD_JADE	314..359	CDD:277048	23/44 (52%)
		ePHD_RNO	367..480	CDD:277177	53/117 (45%)
		TFIIA	2138..>2295	CDD:281188
brpf3b	XP_005166793.1	EPL1	63..231	CDD:287484	40/186 (22%)
		PHD_BRPF	249..302	CDD:277047	25/52 (48%)
		PHD_SF	306..423	CDD:304600	53/117 (45%)
		Kinesin-relat_1	535..>594	CDD:289481	19/59 (32%)
		Bromo_brd1_like	608..705	CDD:99944	19/100 (19%)
		BR140_related	1091..1206	CDD:99900	20/83 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850