DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13875 and RASSF9

DIOPT Version :9

Sequence 1:	NP_001261185.1	Gene:	CG13875 / 38024	FlyBaseID:	FBgn0035104	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_005438.2	Gene:	RASSF9 / 9182	HGNCID:	15739	Length:	435	Species:	Homo sapiens

Alignment Length:	445	Identity:	99/445 - (22%)
Similarity:	176/445 - (39%)	Gaps:	98/445 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LPSQSESFSIWVNGEEHWISGADSSTTCADLICALISYQI----DQKHVLSKEEILAPQQFAIVQ 75
            :.|:.:...:||..||..:.|....||.||:|.||:....    :::.:|.|     |..:.|::
Human    22 MDSEEKEIVVWVCQEEKLVCGLTKRTTSADVIQALLEEHEATFGEKRFLLGK-----PSDYCIIE 81

  Fly    76 KQRHYEEYLDSSARLLDVITS-----PH---AMPKEEYQLHLRHLATSSRKQVPTTDKDSGMGSP 132
            |.|..|..|....|:|.:..:     |:   .:.|.:..|.:....|:..|.|..|:|...: ||
Human    82 KWRGSERVLPPLTRILKLWKAWGDEQPNMQFVLVKADAFLPVPLWRTAEAKLVQNTEKLWEL-SP 145

  Fly   133 VDSSRSMRIRRRGKLLSTKTTDNINTKQSKRSRKQQQRNHHLTPNESLLTIILAQDETILQQMTM 197
            .:..:::...::.:::.       .|.:.....||...:|.....|:|:.:|::||.||.||:..
Human   146 ANYMKTLPPDKQKRIVR-------KTFRKLAKIKQDTVSHDRDNMETLVHLIISQDHTIHQQVKR 203

  Fly   198 LHEKDRQIFKIEEEKHQVRERELGKNYLLETYLKDLDEPQEKGEDLELFEEMTHIDVDRDFGIMS 262
            :.|.|.:|.|.|.:.|..|....|:||:.:.||.......|:..||:..|..|..|:....||..
Human   204 MKELDLEIEKCEAKFHLDRVENDGENYVQDAYLMPSFSEVEQNLDLQYEENQTLEDLSESDGIEQ 268

  Fly   263 DSTVQTALNSGTMQDDIRLY--WLEKIH-EVNKE---------------------------LQCE 297
                        :::.::.|  .::|:. |:.||                           ::|:
Human   269 ------------LEERLKYYRILIDKLSAEIEKEVKSVCIDINEDAEGEAASELESSNLESVKCD 321

  Fly   298 EELL----LSLHSKVRRHQVKRAYQTKSEVLLQIERLDTELATQVADIHHVERKLFTANEQLKAK 358
            .|..    |.:||.:...|.:..|   |:.|||::..:.||..:..:..|:..|   ...|||
Human   322 LEKSMKAGLKIHSHLSGIQKEIKY---SDSLLQMKAKEYELLAKEFNSLHISNK---DGCQLK-- 378

  Fly   359 LAVLECLSREFETTVSGGV---------------QEGDVATGSNASAKVQQSQSD 398
                |..::|.|...|.|.               .:.|....||.|...:.:..|
Human   379 ----ENRAKESEVPSSNGEIPPFTQRVFSNYTNDTDSDTGISSNHSQDSETTVGD 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13875	NP_001261185.1	None
RASSF9	NP_005438.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		99/445 (22%)
		RA_RASSF9	28..120	CDD:340550	24/96 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..435		9/50 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147069
Domainoid	1	1.000	69	1.000	Domainoid score	I9661
eggNOG	1	0.900	-	-		E1_KOG1574
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I5331
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003658
OrthoInspector	1	1.000	-	-		otm42175
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15286
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3544
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.850