Protein Alignment p130CAS and nedd9

DIOPT Version :10

• Sequence 1: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_001070750.1
• Gene: nedd9 / 768136
• ZFINID: ZDB-GENE-061013-318
• Length: 783
• Species: Danio rerio
• Alignment Length: 864
• Identity: 236/864 - (27%)
• Similarity: 382/864 - (44%)
• Gaps: 196/864 - (22%)

  Fly    78 QKLYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVL--NSY 140
            :.|.|||:|||..::.:||.|:|||||||:||:|.|.:|||||||..|||:.|||||::|  ..:
Zfish     4 KNLMAKALYDNVPESPEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIAPGNRLKLLIGPMF 68

  Fly   141 DSGCFSPSPASSPVPSLAASTATLDSSICSAEIYE----NGSVISAVSSSNSNSGGASSGLGSES 201
            |    ..:||:   ||...|.......:....:|:    :.|:.....|::.........|.::
Zfish    69 D----GQTPAT---PSPPHSHTLQQRPLTPQGVYQVPPSHQSIYQTPPSNDLYQVPHRGALAAD- 125

  Fly   202 VSRVSRRSWHASPTKVITPQRHGDVY-----------IYNYSP---------------GSATGSG 240
                      .:|.||:||.|.|..|           :|:..|               |..:.|.
Zfish   126 ----------GTPCKVVTPVRVGQTYAFSPASDSSHDLYDVPPVRPQGVYDIPANKQSGQQSLSR 180

  Fly   241 ARAAPSTPQQQ-IY----SNQSIYQNFAMMSSPRQNASGSEFETYDIPKPATPVPLN-YDSPRSG 299
            |:....||..: :|    ::|.:|.     :.|.:|.:..:...||.|:|:...... ||.|.:.
Zfish   181 AQGVYDTPASRGLYDIPPASQGVYS-----TPPCRNNTAQDEGNYDFPQPSKHKQEGIYDVPPAS 240

  Fly   300 LPKA---SNSTTTSSSSLGTRFETLKSVAASIAEESYDVPRPLILGSNQLQQQMSQMTPSSSASS 361
            |.|:   ||.....||...:|  .:|:.:|.|    ||||                      ||.
Zfish   241 LSKSSPCSNYDFPPSSEQMSR--KVKNDSAGI----YDVP----------------------ASQ 277

  Fly   362 LLTSDSLSLSFSSSNRSSLANMPDYDIPRRNP----LPVRRQQSGLTYDFP------LPPLQEQV 416
            |..|.|..|               |||||..|    ....|.::...||.|      :..:.:.|
Zfish   278 LAASGSQDL---------------YDIPRGMPQNRHASSERDRNKSVYDIPPTDTRMVGDITDGV 327

  Fly   417 PRVL-----CTPSTVTTT---------KELPLELSSALETLAKLQLQTTAAINRLLSFVV-PNWR 466
            .|:.     .|.|:::|:         ..|.|:|.||::.|.::|....::::.|.:... ||||
Zfish   328 NRLSFSSTGSTRSSMSTSSSSAGSPAESRLALDLDSAVQRLNRVQQNLESSVSALQTLTASPNWR 392

  Fly   467 TRAQLEPAIMDLKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHD 531
            |.:.:|....:::::..|::.::.|...||.||..|||...|:.|..|||..::.|.|:::::..
Zfish   393 TYSFMERHANEVRVSLERVKLSMSDFLIFGRGASANATALSDQGLHAKLRRQLQRLEDSHQILLQ 457

  Fly   532 SSESLDAQGAWSIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKR--- 593
            ..::|: ...|:::.|......|.  ..|.|::.::.::||.:|.|...|.|..:|.|||:|
Zfish   458 IYQTLE-DNNWALNILTAGGMHHS--KSDELERFVMVSRTLPDDARQLASTIGSSAELLFRRAPI 519

  Fly   594 ----------------------QLTVGHNGGSGTGVLEGSRGSAEWLEDYDYVAFESKDAAARKN 636
                                  ...|.|:..:    :...:....|::|||||..:.||...|:.
Zfish   520 EGIVHPFTCNPTEDNGFRSQSKPFPVSHDKAN----MNSEKCVKSWMDDYDYVHLQGKDEFERQQ 580

  Fly   637 EALRE----------AIPADLKTQF----DTVIRTAE-------SSAMGAGSGSIPTTPTARTTP 680
            :.|.|          .:..|...||    ..||:..|       |.....||.|..::.......
Zfish   581 KKLLEKENITKQGKVQLGQDQLNQFKQLEQDVIKPVENDITKWISHQNSTGSSSSDSSSNFSMGG 645

  Fly   681 TTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNL 745
            ..|     :..:|::|:.:||.|...|...|:.|:|:|...|:..|||:.|:|:||||::|||.|
Zfish   646 GAP-----LCSRDRQLLGFYADQCEQHFVTLLNAVDAFFGCVKSGQPPRIFVAHGKFVILSAHKL 705

  Fly   746 VTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLA 810
            |.|||.:.|..:...:..:::..:|.|.:.|||.|..:|.||.|:|:.:|||||||.|..:::||
Zfish   706 VFIGDTLSRQATVAEVANRVMNLSNMLCEMLKTVVSSTKIAALHYPNTAAVQEMVDRVTDLSHLA 770

  Fly   811 RDLKSVMLQAVHLSTAAGV 829
            :..|      |.||..||:
Zfish   771 QQFK------VQLSQMAGL 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	35/54 (65%)
		Serine_rich_CAS	434..596	CDD:211403	46/187 (25%)
		CAS_C	611..817	CDD:463437	73/226 (32%)
nedd9	NP_001070750.1	SH3_NEDD9	7..63	CDD:212935	35/55 (64%)
		Serine_rich_CAS	356..519	CDD:471673	47/165 (28%)
		CAS_C	555..777	CDD:463437	74/232 (32%)