Protein Alignment p130CAS and efs

DIOPT Version :10

• Sequence 1: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: XP_012819883.1
• Gene: efs / 734004
• XenbaseID: XB-GENE-490351
• Length: 749
• Species: Xenopus tropicalis
• Alignment Length: 911
• Identity: 205/911 - (22%)
• Similarity: 312/911 - (34%)
• Gaps: 308/911 - (33%)

  Fly    17 VATYHTLPESQTSSVLAKHQQRQLKEPQQP------PQYV--------INSVAMHAKTTTANSIT 67
            :..::|||     |:......|  |.|..|      |.:|        :...|:.....|.:.:|
 Frog    37 ILLFNTLP-----SLWKLPSSR--KSPPLPAFHFILPTFVRSLSLPLLLLPFALAQNCRTGSEVT 94

  Fly    68 ---GGTLHRAKSAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLC 129
               |..|.||:.||     |:|||.|::.:||.|::||::.|||:|.....|||.||||.:||:.
 Frog    95 RCLGRPLFRAQLAQ-----ALYDNAAESPEELSFRRGDVMLVLERDAPSLGGWWRCSLRGQQGIA 154

  Fly   130 PGNRLRVLNSYDSGCFSPSPASSPVPSLAASTATLDSSICSAEIYENGSVISAVSSSNSNSGGAS 194
            |||||::|..     .|...:....|.....||...    ...|.|.|:..:.....|..:|
 Frog   155 PGNRLQLLPE-----TSQQESEYQAPRFLGVTAEAG----RLHINEKGAQENREEPQNHETG--- 207

  Fly   195 SGLGSESVSRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSATGSGAR----AAPSTPQQQIYSN 255
                                     ||......:|.      ..|.||    |.|:..|..||
 Frog   208 -------------------------PQHQTGTEVYQ------VPSIARLCLSAQPTEAQDDIY-- 239

  Fly   256 QSIYQNFAMMSSPR--QNASGSEFETYDIPKPATPVPLN----YDSPRSGLPKASNSTTTSSSSL 314
                      :|||  ........|.||.|......|::    ||||      |....:|.|:::
 Frog   240 ----------NSPRLVGPCIQQPLEVYDTPAALRREPISALDIYDSP------ALRVKSTDSAAV 288

  Fly   315 GTRFETLKSVAASIAEESYDVPRPL-----------------------------------ILGSN 344
                     |...|.|:.||||...                                   ||.|.
 Frog   289 ---------VPEEIPEDIYDVPPTFNKSPSDDEEDEGVYSMPSNLKRVSGLHNLYEAPEDILSSG 344

  Fly   345 QLQQQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGLTYDFPL 409
            ||.:.: |..|:...|...|..:.|...|.|..|:                             :
 Frog   345 QLPETV-QPPPAQRLSVCSTGSTRSADSSGSRESN-----------------------------I 379

  Fly   410 PPLQEQVPRVLCTPSTVTTTKELPLELSSALETLAKL--QLQTTAAINRLLSFVVPNWRTRAQLE 472
            |||....||   ...|.|            :|.|..|  :||.:         :||
 Frog   380 PPLSIWEPR---NDGTCT------------MEGLRMLHQELQVS---------IVP--------- 411

  Fly   473 PAIMDLKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIH------- 530
                  .||.          ||...|..|    .||...|.|   ::.||||...:.|
 Frog   412 ------VLAG----------AEKSTGPGG----PEDSGTAKK---VLGALRDFLVMAHVAGLRSC 453

  Fly   531 -DSSESLDAQGAWSIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKRQ 594
             .|..:|..:.:..:|||     :|..|............|.:.|........:..||.|||.|.
 Frog   454 QASDPALHGELSVHLDQL-----EHAARELVNKGSEKTLFQLILEHSNCFVRIVSANAGLLFPRP 513

  Fly   595 LTVGHNGGSGTGVLEGSRGSAEWLEDYDYVAFESKDAAARKNEALREA--------------IPA 645
                            ...|:|.|......|..:...|.::..::::.              :..
 Frog   514 ----------------RLSSSESLSRRPLPALPTASPAIQRKGSIQDRPLPPPPTLQHVVSDLSD 562

  Fly   646 DLKTQFDTVIRTAESSAMGAGS----------------GSIPTTPTARTTPTTPCKSPEMTDKDK 694
            |:.::::.:..|........||                |.:......:..|     .||::::|.
 Frog   563 DIHSEYERIKCTDNHYVHLQGSITAQNISKHKDRQTDMGQVSAQEERQIEP-----FPELSEEDH 622

  Fly   695 KLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTIGDNVYRNISKE 759
            .|:.:||.|..:|:..|:..:.:||.:. .:|||:.|:.:||.:|::||.||.|||.:.|.:|..
 Frog   623 HLLHFYATQSHSHLQTLLSCVGTFLGSA-SSQPPRVFVGHGKQLVIAAHKLVFIGDTLGRLLSCP 686

  Fly   760 ALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLARDLKSVMLQAVHLS 824
            .|:.::.....||..|||..||.:|:|||.:|:.:|::.|..:|           ||:....|..
 Frog   687 QLQTRLTGEGAALCQALKEVVLATKEAAALYPAPAALKAMAGTV-----------SVLCTCAHSF 740

  Fly   825 T 825
            |
 Frog   741 T 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	28/54 (52%)
		Serine_rich_CAS	434..596	CDD:211403	37/171 (22%)
		CAS_C	611..817	CDD:463437	55/235 (23%)
efs	XP_012819883.1	SH3_EFS	105..165	CDD:212936	31/69 (45%)
		Serine_rich	<433..513	CDD:462610	20/87 (23%)
		FAT-like_CAS_C	620..748	CDD:472510	45/134 (34%)