Protein Alignment p130CAS and CASS4

DIOPT Version :10

• Sequence 1: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_065089.2
• Gene: CASS4 / 57091
• HGNCID: 15878
• Length: 786
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 196/872 - (22%)
• Similarity: 328/872 - (37%)
• Gaps: 234/872 - (26%)

  Fly    80 LYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVLN--SYDS 142
            |.|:|:|||..|.||||.|.:|||||:|||.....:|||.|.|..||||.|.|||::|.  :.|.
Human    14 LLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADR 78

  Fly   143 GC------FSPSPASS------------PVPS--------------------------------- 156
            .|      ...:||||            |.|.
Human    79 PCPPFLRGLEEAPASSEETYQVPTLPRPPTPGPVYEQMRSWAEGPQPPTAQVYEFPDPPTSARII 143

  Fly   157 ------------------LAASTATLDSSICSAEIYENGSVISA---------VSSSNSNSG--- 191
                              :.||..||.|.:........|.|:..         :.:|...:|
Human   144 CEKTLSFPKQAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHP 208

  Fly   192 --GASSGLGSE--SVSRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSA----TGSGARAAPSTP 248
              ..:||.|..  ||:.:.|..:...|    .||:...:|....|||.|    |...:.|..|.|
Human   209 PDSQASGQGVPLISVTTLRRGGYSTLP----NPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRP 269

  Fly   249 QQQIYSNQSIYQNFAMMS---SPRQN--------ASGSEFETYDIPKPATPVPL----NYDSPRS 298
            .....|:.:.|...:..|   :|:.|        .|..|..:|....|....||    :|..|.|
Human   270 HALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRGTFPLDEDVSYKVPSS 334

  Fly   299 ----------------GLPKASNSTTTSSSSLGTRFETLKSVAASIAEESYDVPRPLILGSNQLQ 347
                            .:|||    |:|.|..|...|..|.|:.:.|..:          |:...
Human   335 FLIPRVEQQNTKPNIYDIPKA----TSSVSQAGKELEKAKEVSENSAGHN----------SSWFS 385

  Fly   348 QQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGLTYDFPLPPL 412
            ::.:..:|.....|..:|||.:...||.:.:|..:.
Human   386 RRTTSPSPEPDRLSGSSSDSRASIVSSCSTTSTDDS----------------------------- 421

  Fly   413 QEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVVPNWRTRAQLEPAIMD 477
                    .:.|:..:.|||.|:|..|.||:..||.:..:::..|:.||...||.|..||..|..
Human   422 --------SSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDA 478

  Fly   478 LKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHDSSESLDAQGAW 542
            :..:...:..::.:..:|..|..|.|....|.||..::|..::.:.::.:::.::.||||.:. |
Human   479 IHRSTDHIEESVREFLDFARGVHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRN-W 542

  Fly   543 SIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKR--------QLTVGH 599
            .::.|.....::.   ||.|::.::.|:.|.||::...|.:..|..|||||        |||
Human   543 PLEVLVTDSVQNS---PDDLERFVMVARMLPEDIKRFASIVIANGRLLFKRNCEKEETVQLT--- 601

  Fly   600 NGGSGTGVLEGSRGSAEW-LEDYDYVAFESKDAAARKNEALREAIPADLKTQFD---TVIRTAES 660
                         .:||: .|.|       .....|:.|:.:::.|:..:.:.:   .:::...:
Human   602 -------------PNAEFKCEKY-------IQPPQRETESHQKSTPSTKQREDEHSSELLKKNRA 646

  Fly   661 SAMGAGSGSIPTTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKN 725
            :..|...|.:...|:::.||.   :.|.:::.    .|.|       .|.|.:||.:|..::..:
Human   647 NICGQNPGPLIPQPSSQQTPE---RKPRLSEH----CRLY-------FGALFKAISAFHGSLSSS 697

  Fly   726 QPPKFFIAYGKFVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHF 790
            ||.: .|...|.|::....||   |.:.....:..:|.:|||.::.|...||...|.:|.|...:
Human   698 QPAE-IITQSKLVIMVGQKLV---DTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTY 758

  Fly   791 PSGSAVQEMVDSVVHINNLARDLKSVM 817
            ||.:|:..:......:....|..:..:
Human   759 PSPAALGHLQAEAEKLEQHTRQFRGTL 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	32/54 (59%)
		Serine_rich_CAS	434..596	CDD:211403	45/169 (27%)
		CAS_C	611..817	CDD:463437	42/209 (20%)
CASS4	NP_065089.2	SH3_CASS4	14..70	CDD:212933	33/55 (60%)
		Atrophin-1	99..>347	CDD:460830	43/251 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..295		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..429		15/114 (13%)
		Serine_rich_CASS4	435..593	CDD:211405	44/161 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	612..670		8/60 (13%)
		FAT-like_CASS4_C	665..786	CDD:211409	32/139 (23%)