DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p130CAS and CASS4

DIOPT Version :9

Sequence 1:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001157588.1	Gene:	CASS4 / 57091	HGNCID:	15878	Length:	786	Species:	Homo sapiens

Alignment Length:	872	Identity:	196/872 - (22%)
Similarity:	328/872 - (37%)	Gaps:	234/872 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVLN--SYDS 142
            |.|:|:|||..|.||||.|.:|||||:|||.....:|||.|.|..||||.|.|||::|.  :.|.
Human    14 LLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADR 78

  Fly   143 GC------FSPSPASS------------PVPS--------------------------------- 156
            .|      ...:||||            |.|.
Human    79 PCPPFLRGLEEAPASSEETYQVPTLPRPPTPGPVYEQMRSWAEGPQPPTAQVYEFPDPPTSARII 143

  Fly   157 ------------------LAASTATLDSSICSAEIYENGSVISA---------VSSSNSNSG--- 191
                              :.||..||.|.:........|.|:..         :.:|...:|
Human   144 CEKTLSFPKQAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHP 208

  Fly   192 --GASSGLGSE--SVSRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSA----TGSGARAAPSTP 248
              ..:||.|..  ||:.:.|..:...|    .||:...:|....|||.|    |...:.|..|.|
Human   209 PDSQASGQGVPLISVTTLRRGGYSTLP----NPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRP 269

  Fly   249 QQQIYSNQSIYQNFAMMS---SPRQN--------ASGSEFETYDIPKPATPVPL----NYDSPRS 298
            .....|:.:.|...:..|   :|:.|        .|..|..:|....|....||    :|..|.|
Human   270 HALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRGTFPLDEDVSYKVPSS 334

  Fly   299 ----------------GLPKASNSTTTSSSSLGTRFETLKSVAASIAEESYDVPRPLILGSNQLQ 347
                            .:|||    |:|.|..|...|..|.|:.:.|..:          |:...
Human   335 FLIPRVEQQNTKPNIYDIPKA----TSSVSQAGKELEKAKEVSENSAGHN----------SSWFS 385

  Fly   348 QQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGLTYDFPLPPL 412
            ::.:..:|.....|..:|||.:...||.:.:|..:.
Human   386 RRTTSPSPEPDRLSGSSSDSRASIVSSCSTTSTDDS----------------------------- 421

  Fly   413 QEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVVPNWRTRAQLEPAIMD 477
                    .:.|:..:.|||.|:|..|.||:..||.:..:::..|:.||...||.|..||..|..
Human   422 --------SSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDA 478

  Fly   478 LKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHDSSESLDAQGAW 542
            :..:...:..::.:..:|..|..|.|....|.||..::|..::.:.::.:::.::.||||.:. |
Human   479 IHRSTDHIEESVREFLDFARGVHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRN-W 542

  Fly   543 SIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKR--------QLTVGH 599
            .::.|.....::.   ||.|::.::.|:.|.||::...|.:..|..|||||        |||
Human   543 PLEVLVTDSVQNS---PDDLERFVMVARMLPEDIKRFASIVIANGRLLFKRNCEKEETVQLT--- 601

  Fly   600 NGGSGTGVLEGSRGSAEW-LEDYDYVAFESKDAAARKNEALREAIPADLKTQFD---TVIRTAES 660
                         .:||: .|.|       .....|:.|:.:::.|:..:.:.:   .:::...:
Human   602 -------------PNAEFKCEKY-------IQPPQRETESHQKSTPSTKQREDEHSSELLKKNRA 646

  Fly   661 SAMGAGSGSIPTTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKN 725
            :..|...|.:...|:::.||.   :.|.:::.    .|.|       .|.|.:||.:|..::..:
Human   647 NICGQNPGPLIPQPSSQQTPE---RKPRLSEH----CRLY-------FGALFKAISAFHGSLSSS 697

  Fly   726 QPPKFFIAYGKFVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHF 790
            ||.: .|...|.|::....||   |.:.....:..:|.:|||.::.|...||...|.:|.|...:
Human   698 QPAE-IITQSKLVIMVGQKLV---DTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTY 758

  Fly   791 PSGSAVQEMVDSVVHINNLARDLKSVM 817
            ||.:|:..:......:....|..:..:
Human   759 PSPAALGHLQAEAEKLEQHTRQFRGTL 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	32/54 (59%)
		Serine_rich_CAS	434..596	CDD:211403	45/169 (27%)
		DUF3513	612..817	CDD:288849	42/208 (20%)
CASS4	NP_001157588.1	SH3_CASS4	14..70	CDD:212933	33/55 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..295		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..429		15/114 (13%)
		Serine_rich_CASS4	435..593	CDD:211405	44/161 (27%)
		DUF3513	595..785	CDD:288849	45/230 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..670		8/60 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143742
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10654
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.910