DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p130CAS and bcar1

DIOPT Version :9

Sequence 1:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001119536.1	Gene:	bcar1 / 447979	XenbaseID:	XB-GENE-955189	Length:	951	Species:	Xenopus tropicalis

Alignment Length:	1003	Identity:	254/1003 - (25%)
Similarity:	396/1003 - (39%)	Gaps:	324/1003 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 AKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVL--------- 137
            |||:|||.|::.|||.|:||||:||||::|:|.:|||||||..|||:.|||||::|
Frog     8 AKALYDNVAESPDELSFRKGDIMTVLERNTQGLEGWWLCSLHGRQGIVPGNRLKILVGMYDKKQG 72

  Fly   138 -------------------------------------------NSYDS----------------- 142
                                                       ::|.|
Frog    73 SGDQCQQKPQQQTQQQPPQIPLNYQPQGVYNVVTSSNQYTPMHSAYQSPGGEHVYLMPASSKGQQ 137

  Fly   143 ------------GCFSPS---------PASSPVPSLAASTATLDSSI-CSAEIYE---------- 175
                        |..:||         ||..|.||.......:..|: .|.|:|:
Frog   138 GLYQNPQGPQHPGQITPSKQPSLYQNQPAQHPFPSQVQDIYQVPPSLNQSQELYQVPVGSISPPQ 202

  Fly   176 ----------NGSV--ISAVSSSNSNSGGASSGLGSESVSRVSRRSWHASPTKVITPQRHGDVYI 228
                      :|:|  |..|..|.::|........|..:..|..|.   :|.||:.|.|.|.:|:
Frog   203 PHDVYQVPPSSGTVQDIYHVPPSITSSQEIYQVPPSMDMRAVEVRK---APGKVVLPTRVGQLYV 264

  Fly   229 YN---------YSPGSATGSGARAAPSTPQQQIYS--NQSIYQNFAMMSSPRQNASGSEFETYDI 282
            |:         |......|      ||.| |:||.  ::.:..|:    ||         |.|||
Frog   265 YDTPKLEQQDEYDVPRHLG------PSGP-QEIYDVPSRCLVNNY----SP---------EVYDI 309

  Fly   283 PKPATPVPLN-------YDSPRS----------------GLPKASNSTTTSSSSLGTRFET---- 320
            |..|...|::       ||.|.|                .:|.:.:.......   ||.||
Frog   310 PPMAVKGPVSREQTQEIYDVPPSIEKNLHDQLQSHLMIYDIPPSVSKDVPDGP---TREETYDFP 371

  Fly   321 ------------------LKSVAASIAEESYDVPRPLILGSN-QLQQQMSQMTPS--SSASSLLT 364
                              |.....:|.||.||:|...|.||: ...|::..:.||  ..|.....
Frog   372 PTFPSQKMQGPPQATTHALHEHEPNIPEEIYDIPPTAIKGSDTSFSQEIYDVPPSLRKPAGQTFH 436

  Fly   365 SDSLSLSFSSSNRSSLANMPDYDIPR--RNPLPVRRQQSGLTYDFPLPPLQEQVPRV-------- 419
            .|.                  ||:||  .:..|....::...||.| |.:..:|..|
Frog   437 HDV------------------YDVPREFHSGKPTTESETDYIYDVP-PQVDREVKAVDELVGNFK 482

  Fly   420 -LCTPSTVTTT-------------------------KELPLELSSALETLAKLQLQTTAAINRLL 458
             |...||.:|.                         |||.|:|.:|:|.|.|||....::::.|:
Frog   483 RLSASSTGSTRSNISTSSLDTIPVKEPAVILPKPAGKELNLDLEAAMELLVKLQHGVNSSVSYLM 547

  Fly   459 SFVVPNWRTRAQLEPAIMDLKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALR 523
            ||:...||:..|:|..|..::.|...:::.:.:|.||..||:.|:.::.||.|..||...::.:.
Frog   548 SFLNGPWRSLEQMEANIQSIQSAVEGVKSAMKELLEFARGAVVNSAQASDRTLHTKLSKQLQKME 612

  Fly   524 DANKLIHDSSESLDAQGAWSIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNAS 588
            :.|:.:...|::|| ...||::.||.:.:    ...|.|::.::.::.:.:|.:...||:.||||
Frog   613 EVNQQLIKHSQALD-NCNWSLNILATNKQ----NTSDDLERFIMYSKGIPDDTKQLASFLHGNAS 672

  Fly   589 LLFKR----------------------QLTVGHNGGSGTGVL-----------------EGSRGS 614
            |||||                      .|:||..|.:....:                 ||...:
Frog   673 LLFKRAKHPLSLSDLQDNSNHFSNNNNNLSVGQTGHTEKASIQSRPLPSPPKFLAEQSPEGQYEN 737

  Fly   615 AE--WLEDYDYVAFESKDAAARKNEALREA----------IPADLKTQF----DTVIRTAESSAM 663
            .|  |:||||||..:.|:...:..:.|.|.          :......||    :.|:|..||...
Frog   738 NESGWMEDYDYVHLQGKEEFEKTQKELLEKGNIIKQGKGHLEQQQLKQFERLEEEVVRPIESDLS 802

  Fly   664 GAGSGSIPTTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPP 728
            .       .||....:..    ...:::.|::|:.:|.:|...::..|..|||:|..::..||||
Frog   803 N-------WTPPQHYSKV----QSALSNSDRQLLLFYQEQCEANVTTLTNAIDAFYNSISSNQPP 856

  Fly   729 KFFIAYGKFVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSG 793
            |.|:|:.|||::|||.||.|||.:.|....:.:|.|:...:|.|.|.||..||.:|.||..:||.
Frog   857 KIFVAHSKFVILSAHKLVFIGDTLSRQAKAQDIRNKVTHHSNLLCDKLKEIVLTTKTAALQYPSP 921

  Fly   794 SAVQEMVDSVVHINNLARDLKSVMLQAV 821
            :|.::|||.|..:|:.::..:.|:.|.|
Frog   922 AAAKDMVDRVKDLNSSSQQFRMVLGQLV 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	36/53 (68%)
		Serine_rich_CAS	434..596	CDD:211403	50/183 (27%)
		DUF3513	612..817	CDD:288849	67/220 (30%)
bcar1	NP_001119536.1	SH3_BCAR1	4..70	CDD:212934	37/61 (61%)
		Atrophin-1	<97..>431	CDD:367360	71/359 (20%)
		PRK10263	<97..>221	CDD:236669	17/123 (14%)
		Serine_rich_BCAR1	523..680	CDD:211406	50/161 (31%)
		DUF3513	736..945	CDD:371854	67/219 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5953
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3200
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	1	1.000	-	-		FOG0004232
OrthoInspector	1	1.000	-	-		otm49002
Panther	1	1.100	-	-	O	PTHR10654
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17373
SonicParanoid	1	1.000	-	-		X2975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190