DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p130CAS and Cass4

DIOPT Version :9

Sequence 1:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001366394.1	Gene:	Cass4 / 320664	MGIID:	2444482	Length:	806	Species:	Mus musculus

Alignment Length:	890	Identity:	208/890 - (23%)
Similarity:	334/890 - (37%)	Gaps:	235/890 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GTLHRAKSAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNR 133
            ||..|..:.:.|.|:|:|||:||.||||.|.:|||||::||:....:|||.|.|..||||.|.||
Mouse     3 GTSIREGAPKTLLARALYDNHADCSDELAFSRGDILTIVEQNVPESEGWWRCLLHGRQGLAPANR 67

  Fly   134 LRVLNSYDSGCFSPSPASSPVPSLAASTAT-LDSSICSAEIYE------NGSVISAVSSSNSNSG 191
            |:||..        :||..|.|.|.....| |.||....::.:      .|.|...:
Mouse    68 LQVLRE--------TPADRPCPLLPRGPDTDLTSSGAPYQVQDLISPPPQGPVYEPM-------- 116

  Fly   192 GASSGLGSESVSRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSA-----------------TGS 239
                            |||...|:.. |.|    ||....||.||                 ...
Mouse   117 ----------------RSWVEGPSPA-TAQ----VYELPESPSSARIICEKTLSFPKQALSVLPR 160

  Fly   240 GARAAPSTPQQQIYSNQSIYQNFAMMSSPRQNASGSEFETYDIPKPATPVPLNYDSPRSGLPKAS 304
            ..||:..|...|:|......|.|:.:    :.....:|  ||||..:....|:     |...:||
Mouse   161 PTRASLPTLPSQVYDVPVQRQGFSTL----ERLEKQQF--YDIPTSSQKALLH-----SSTSQAS 214

  Fly   305 NSTTTSSSSLGTR----FETLKSVAASIAEESYDVPRPLILGSNQLQQQMSQMTPSSSA-----S 360
            ....|.:.::..|    :..|.|...|  |..:|.| .|:..::.....|:..|..|.:     |
Mouse   215 GRDVTLAPTMAFRQGGGYNPLSSPQKS--ERIHDTP-VLLEKADVRNVSMTSFTKDSGSRAIPGS 276

  Fly   361 SLLTSDSLSLSFSSSN----RSSLANMPDYDIP-RRNPLPVRRQQSGLTYDFP----LPPLQEQ- 415
            |.:.:.:::||....|    ::||...|.|..| .|:|||   ..:|.:|..|    :|.:::|
Mouse   277 SAVHTGAVALSPQLGNTVQRKNSLPEEPTYAFPTSRDPLP---SDAGGSYKVPSRFLIPRVEQQN 338

  Fly   416 -VPRVLCTP-------------------------------------------------------- 423
             :|.:..||
Mouse   339 TMPNIYDTPKAMQGVSHNAPKAMQGVSLAGKELERGREAPENSPWISGQTSFLSPDSDRLSVASS 403

  Fly   424 ---------------------STVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVVPNWRT 467
                                 |:..:.|||.:::..|.||...||.:..::...||.||...||.
Mouse   404 DSRASVVSSCSSISMDSSSGSSSEDSVKELWMDVDFAKETAVSLQHKVASSAAGLLLFVSRTWRF 468

  Fly   468 RAQLEPAIMDLKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHDS 532
            :..||..|..::.||..:..::.:..:|.:|..|.|....|..|..::|..::.:..:.:.:.|:
Mouse   469 KDSLETNIHRIRRAADHVEESVREFLDFAQGVGGTACNLTDSYLQARIRDQLQTISSSYQTLLDA 533

  Fly   533 SESLDAQGAWSIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKRQLTV 597
            ..||| :..||::.|.....::..   |.|::.:..|:.:.|||:..||.:..|..||||:....
Mouse   534 KGSLD-RCNWSLEVLVTDKVQNSL---DDLERFVATARIVPEDVKRFTSIVIANGKLLFKQNCEK 594

  Fly   598 GHNGGSGTGVLEGSRGSAEWLEDYDYVAFESKDAAARKNEALREAIPADLKTQFDTVIRTAESS- 661
            |                     :.|...........|:.|:.:|:.|.|.:...:.....|..:
Mouse   595 G---------------------EMDLKCERCIRPPQRETESYQESSPFDRQPTTEHSFELARKNR 638

  Fly   662 -----------------AMGAGSGSIP----TTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQIS 705
                             .|...|...|    .:|...|:|     ||...:.::|:  :.::...
Mouse   639 VNVCWQQSPNLQEKGKPTMEGKSNRNPDFHGMSPPPLTSP-----SPSGQNTERKI--HLSKHSR 696

  Fly   706 THMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTIGDNVYRNISKEALREKILRCTN 770
            .:.|.|.:||..|..::...|||:.||...|.|:.....||   |.:.....::..|.:||..::
Mouse   697 LYFGALFKAISVFASSLSNGQPPEVFITQSKLVITVGQKLV---DTLCSETQEKDERNEILCGSS 758

  Fly   771 ALSDALKTCVLKSKKAAAHFPSGSA---VQEMVDSVVHINNLARD 812
            .|...||...|.:|.|...:||.||   :|..|:.:.|.:...||
Mouse   759 HLCGLLKDLALATKSAVIQYPSPSALSLLQSEVERLEHHSRKFRD 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	32/54 (59%)
		Serine_rich_CAS	434..596	CDD:211403	43/161 (27%)
		DUF3513	612..817	CDD:288849	49/226 (22%)
Cass4	NP_001366394.1	SH3_CASS4	14..70	CDD:212933	33/55 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..397		0/25 (0%)
		Serine_rich	435..590	CDD:400950	42/158 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..630		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..688		8/48 (17%)
		FAT-like_CAS_C	685..806	CDD:417131	34/124 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10654
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.900