Protein Alignment p130CAS and Cass4

DIOPT Version :9

• Sequence 1: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: XP_006235741.1
• Gene: Cass4 / 296409
• RGDID: 1310643
• Length: 808
• Species: Rattus norvegicus
• Alignment Length: 886
• Identity: 201/886 - (22%)
• Similarity: 318/886 - (35%)
• Gaps: 260/886 - (29%)

  Fly    69 GTLHRAKSAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNR 133
            ||..|..:.:.|.|:|:|||:.|.||||.|.:|||||::||:....:|||.|.|..||||.|.||
  Rat     3 GTGIREGATKTLLARALYDNHPDCSDELAFSRGDILTIVEQNVPESEGWWKCLLHGRQGLAPANR 67

  Fly   134 LRVLNS--YDSGC-----------------------FS-----------------PSPASSPV-- 154
            |:||..  .|..|                       ||                 ||||::.|
  Rat    68 LQVLRETPVDRPCPLPPRGLDSDLTGSEAPCQVFNSFSPPTPGPVYEPMKSWVEGPSPATAQVYE 132

  Fly   155 ----PSLA-----------------------ASTATLDSSICSAEIYENGS-------------- 178
                ||.|                       ||..||.|.:....:....|
  Rat   133 LPDSPSSARIICEKTLNFPKQALFVLPRPTRASLPTLPSQVYDVPVQRQVSSTLERPEKQQFYDI 197

  Fly   179 ------VISAVSSSNSNSGGAS--------SGLGSESVSRVSRRSW-HASPTKVITPQRHGDVYI 228
                  .:..:|:|.::..|.:        .|.|...:|...:..| |.:|..:      |...:
  Rat   198 PTSSQKAVFHISTSQASGPGVTLAPTTAFRQGGGYNPLSSPQKSDWIHDTPVSL------GKADV 256

  Fly   229 YNYS-------------PGSAT------------GSGARAAPSTPQQQIY--------------- 253
            .|.|             |||:.            |:..:...|.|::..|
  Rat   257 RNASMTSFTKESCSNTIPGSSVVRIGAVTLSPQLGNAVQKKSSPPEETSYAFLTPRGDSLPSDAG 321

  Fly   254 SNQSIYQNFAMMSSPRQNASGSEFETYDIPKPATPVPLNYDSPRSGLPKASNSTTTSSSSLGTRF 318
            |:..:...|.:....|||...:   .||.||....|..|                ||.::.|.
  Rat   322 SSYKVPSRFLIPRVERQNTKPN---IYDTPKAMQGVFQN----------------TSKATQGV-- 365

  Fly   319 ETLKSVAASIAEESYDVPRPLILGSNQLQQQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANM 383
                |:|....|...:.|.    .|..:.:|.:.::|.|...|:.:|||.:...||.:..|..:.
  Rat   366 ----SLAGKELERGREAPE----NSPWVSRQTNFLSPDSDRLSVASSDSRASVVSSCSSLSTDSS 422

  Fly   384 PDYDIPRRNPLPVRRQQSGLTYDFPLPPLQEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQL 448
            |.                                     .|:..:.|||.::|..|.||...||.
  Rat   423 PG-------------------------------------SSSEDSVKELWMDLDFAKETAVALQS 450

  Fly   449 QTTAAINRLLSFVVPNWRTRAQLEPAIMDLKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLAL 513
            :..:::..||.||...||.:..||..:..::.||.|:..:|.:..:|.:|..|.|....|..|..
  Rat   451 RVASSVAGLLLFVSRTWRFKDSLETNVNRIRGAADRVEESLREFLDFAQGVGGLACNLTDSYLQA 515

  Fly   514 KLRPLVRALRDANKLIHDSSESLDAQGAWSIDQLARSDEKHGCRPPDALDQLMVCAQTLTEDVRS 578
            ::|..::.:..:.:.:.|:..:|| :..||::.|.....:...   |.|::.:..|:.:.|||:.
  Rat   516 RVRDQLQTISSSYQTLLDAKGTLD-RCNWSLEVLVVDKAQSSV---DDLERFVQVARVVPEDVKR 576

  Fly   579 TTSFIQGNASLLFKRQLTVGHNGGSGTGVLEGSRGSAEW----------LEDYDYVAFES---KD 630
            .||.:..|..||||:..               .||..:|          .|...:....|   |.
  Rat   577 FTSIVVANGKLLFKQNC---------------ERGEVDWRCERCIQPPQREAESHPERSSPFHKQ 626

  Fly   631 AAARKNEALREAIPADLKTQFDTVIRTAESSAMGAGSGSIPTTPTARTTPT-TPCKSPEMTDKDK 694
            .||..:..|.:....|:..|....::....:.|...|..  ......|:|| .|..||...:.::
  Rat   627 PAAEHSLELAKKSRGDVCGQKSPNLQKKGKNTMEGKSNE--NQDFCGTSPTPLPSPSPSGQNVER 689

  Fly   695 KLVRYYAQQISTH----MGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTIGDNVYRN 755
            |:      ::|.|    .|.|.:||..|..::..:|||:.||...|..:.....||   |.:...
  Rat   690 KI------RLSEHSRLYFGALFKAIGVFASSLSNSQPPEVFITQSKLAITIGQKLV---DTLCSE 745

  Fly   756 ISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAV 796
            ..:...|.:||..::.|...||...|.:|.|...:||.||:
  Rat   746 TQERDERNEILCGSSHLCGLLKDLALATKNAVIQYPSPSAL 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	31/54 (57%)
		Serine_rich_CAS	434..596	CDD:211403	44/161 (27%)
		DUF3513	612..817	CDD:288849	49/203 (24%)
Cass4	XP_006235741.1	SH3_CASS4	14..70	CDD:212933	32/55 (58%)
		Serine_rich	436..591	CDD:285975	43/158 (27%)
		FAT-like_CAS_C	688..808	CDD:300863	30/108 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm63532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10654
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.910