Protein Alignment p130CAS and Nedd9

DIOPT Version :9

• Sequence 1: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_001011922.1
• Gene: Nedd9 / 291044
• RGDID: 1306276
• Length: 833
• Species: Rattus norvegicus
• Alignment Length: 898
• Identity: 229/898 - (25%)
• Similarity: 372/898 - (41%)
• Gaps: 228/898 - (25%)

  Fly    78 QKLYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVLNSYDS 142
            :.|.|:|:|||..:.::||.|:|||||||:||:|.|.:|||||||..|||:.||||:::|   ..
  Rat     4 KNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL---IG 65

  Fly   143 GCFSPSPASSPVPSLAASTATLDSSICSAEIYE--NG-----SVISAVSSSNSNSG----GASSG 196
            ....||....|.|      ..:..:....::|:  |.     ..|..|..|..|.|    ....|
  Rat    66 PVQEPSSHEQPTP------GPMHQNFGQQKLYQVPNSQAAPRDTIYQVPPSYQNQGIYQVPTGHG 124

  Fly   197 LGSESVSRV---------SRRSWHASPTKVITPQR--HGDVY---------IYNYSPGSATGSGA 241
            ...:.|.:|         |....|.. .|||||.|  ||.||         :|:..|...|....
  Rat   125 TPEQDVYQVPPSVQRNIGSTNGPHLG-KKVITPVRVGHGYVYEHPSRYQKDVYDVPPSHTTQGVY 188

  Fly   242 RAAPSTPQQQIYS-------NQSIYQ------NFAMMSSPRQNASGSEFETYDIPKP-------- 285
            ...||:.:..::|       .|.:|.      .:|:..|..::.:|...:.||.|.|
  Rat   189 DIPPSSVKGPVFSVPVGELKPQGVYDIPPTQGVYAIPPSACRDEAGLREKEYDFPPPMKQDGKLD 253

  Fly   286 ATPVPLNYDSPRSGLPKASNSTTTSSSSLGTRFE-----------------TLKSVAASIA---- 329
            ..|..: ||.|       ..||.|....|.|:|.                 :|....:.:.
  Rat   254 TRPEGV-YDIP-------PTSTKTVGKDLHTKFPCDAPGGAEPMARRHQSLSLHHAPSQVGPSGD 310

  Fly   330 --EESYDVPR--------------------------PL-----ILGSNQLQQQMSQMTPSSSASS 361
              .::|||||                          ||     ..||..:...:::::.||:.|
  Rat   311 TQSDAYDVPRGVQFLEVPTESSEKANLEERDGVYDVPLHNPADAKGSRDVVDGINRLSFSSTGS- 374

  Fly   362 LLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGLTYDFPLPPLQEQVPRVLCTPSTV 426
              |..::|.|.:||..|||:..|..|
  Rat   375 --TRSNMSTSSTSSKESSLSASPSQD--------------------------------------- 398

  Fly   427 TTTKELPLELSSALETLAKLQLQTTAAINRLLSFVVPNWRTRAQLEPAIMDLKLAALRLRTTLHD 491
               |.|.|:..:|:..|..||......|..|:|.|..:||:...:|..|.:::.|..::...|.:
  Rat   399 ---KRLLLDPDTAIGKLYWLQQTLETGICSLMSLVTIDWRSYGYMERHINEIRTAVDKVELFLRE 460

  Fly   492 LAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHDSSESLDAQGAWSIDQLARSDEKHGC 556
            ...|..|||.||:...:..|..|:...::.:.|:::::..:|..|: :.:||::.||.:..::.|
  Rat   461 YLHFARGALANASCLPEPVLLNKMNRELQRVDDSHQILSQTSHDLN-ECSWSLNVLAINKPQNKC 524

  Fly   557 RPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFK----------------RQLTVGHNG---- 601
               |.||:.::.|:|:.:|.:..|:.|...|..||:                ..:...|.|
  Rat   525 ---DDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRVDPGNSHLKNGPDSITNSIEYTHTGSQMQ 586

  Fly   602 ----GSGTGVL--------------------EGSRGSAEWLEDYDYVAFESKDAAARKNEAL--R 640
                |...|.:                    :||..|  |::|||||..:.|:...|:.:.|  :
  Rat   587 PLRPGDYKGQVHNKPLPPTLSKEQPPDCSSSDGSERS--WMDDYDYVHLQGKEEFERQQKELLEK 649

  Fly   641 EAIPADLKTQFD----TVIRTAESSAMGAGSGSIPTTPTARTTPTTPCKSPEMTDKDKKLVRYYA 701
            |.|....|.|.:    :..:..|..........|.....:::.|||   :..:..:|::|:.:|.
  Rat   650 ENIMKQSKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTT---NNSVGAQDRQLLCFYY 711

  Fly   702 QQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTIGDNVYRNISKEALREKIL 766
            .|..||..:|:.|||:....|...|||:.|:|:.|||::|||.||.|||.:.|.::.:.:|.|:.
  Rat   712 DQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVR 776

  Fly   767 RCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLARDLKSVMLQ 819
            ..:|.|.:.|||.|:.:|.||.|:||.:|:||||..|..::..|:..|..:|:
  Rat   777 NSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLE 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	33/54 (61%)
		Serine_rich_CAS	434..596	CDD:211403	42/177 (24%)
		DUF3513	612..817	CDD:288849	69/210 (33%)
Nedd9	NP_001011922.1	SH3_NEDD9	7..63	CDD:212935	33/55 (60%)
		Serine_rich_CAS	400..561	CDD:298275	43/164 (26%)
		DUF3513	620..827	CDD:288849	70/211 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337509
Domainoid	1	1.000	121	1.000	Domainoid score	I5561
eggNOG	1	0.900	-	-		E1_28I76
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3168
OMA	1	1.010	-	-		QHG46840
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	1	1.000	-	-		FOG0004232
OrthoInspector	1	1.000	-	-		otm63532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10654
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2975
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870