Protein Alignment p130CAS and Efs

DIOPT Version :9

• Sequence 1: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_001099503.1
• Gene: Efs / 290212
• RGDID: 1308966
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 794
• Identity: 188/794 - (23%)
• Similarity: 273/794 - (34%)
• Gaps: 285/794 - (35%)

  Fly    74 AKSAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQD-TEGFQGWWLCSLRNRQGLCPGNRLRVL 137
            |.|||  .|:|:|||.|::..||.|::||:|.||::: ..|..||.||||..:||:.|.||:::|
  Rat     4 ATSAQ--LARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLL 66

  Fly   138 NSYDSGCFSPSPASSPVPSLAASTATLDSSICSAEIYENGSVISAVSSSNSNSGGASSGLGSESV 202
            .:        |||..|             |:|.
  Rat    67 PA--------SPAPKP-------------SLCP-------------------------------- 78

  Fly   203 SRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSATGSGARAAPSTPQQQIYSNQSIYQNFAMMSS 267
                     |.||:                ||.:                             |.
  Rat    79 ---------APPTQ----------------PGCS-----------------------------SC 89

  Fly   268 PRQNASGSEFETYDIPKPATPVPLNYDSPRSGLPKASNSTTTSSSSLGTRFETLKSVAASIAEES 332
            |.......|.|.|.||.||.|      ...||||..|.|.::.|.....|...::..|.....|.
  Rat    90 PTPERGCEEQEVYVIPPPARP------CSASGLPARSCSPSSDSIYKVPRVNGIQLTAPRDVGEV 148

  Fly   333 YDVPRPLILGSNQLQQQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVR 397
            |||| |.||           ..||                         |.| ||.|.....|.
  Rat   149 YDVP-PNIL-----------RAPS-------------------------NCP-YDSPASFSCPA- 174

  Fly   398 RQQSGLTYDFPLPPLQEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVV 462
                  |...|.||.:::.|            .::||.|.|..|....|:
  Rat   175 ------TPVVPQPPGEDEAP------------YDVPLALKSPAEMEPDLE--------------- 206

  Fly   463 PNWRTRAQLEPAIMDLKLAA---LRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRD 524
              |....:..|.:    .||   |:..:.|.:|.|..|..|.|...                 ||
  Rat   207 --WEGGREPGPPL----YAAPSNLKRASALLNLYEAPEELLANGES-----------------RD 248

  Fly   525 ANKLIHD---------------SSESLDAQGAWSIDQLARS-DEKHGCRPP--DALDQLMVCAQT 571
            |::.|:|               :|.|.|......:  |.|| ..:|..|.|  ::|.:..:.|..
  Rat   249 ADEGIYDVPLLGPEPPSPEPPAASSSADPDTVAQL--LTRSPPPQHRPRLPSTESLSRRPLPALP 311

  Fly   572 LTEDVRST--TSFIQGNASLLFKRQL------TVGHNGGSGTGVLE---------GSRGSAEWL- 618
            ::|....:  .|...|....:..|.|      ..|:.|....|..|         |.....|.:
  Rat   312 VSEAPAPSPAPSPAPGRKGSIQDRPLPPPPPCLPGYGGLKPEGDPECREVDSDSGGPHNEYEGIP 376

  Fly   619 --EDYDYVAFESKDAAARKNEALREAIPADLKTQFDTVIRTAESSAMGAGSGSIPTTPTARTTPT 681
              |:||||..:..| .|:.:..|..|.|||.:.....::...|:.:        |..|...:|
  Rat   377 MAEEYDYVHLKGVD-KAQGSRPLDNAFPADPELLERGLVEQKEALS--------PEEPLVLST-- 430

  Fly   682 TPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLV 746
                      .|.:|:.:||.|..:|...|..|:.:.:.:.:.||||..|:.:||.|||:||.||
  Rat   431 ----------GDLQLLHFYAGQCQSHYSALQTAVAALMSSTQANQPPCLFVPHGKRVVVAAHRLV 485

  Fly   747 TIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLAR 811
            .:||.:.|..:...||.::......|:..|:..||..|.||..:||.:|||||          ||
  Rat   486 FVGDTLGRLAASAPLRAQVGAAGTVLAQTLRATVLAVKGAALGYPSDTAVQEM----------AR 540

  Fly   812 DLKSVMLQAVHLST 825
            .:..:..||:..:|
  Rat   541 CVAELAGQALRFTT 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	26/55 (47%)
		Serine_rich_CAS	434..596	CDD:211403	37/190 (19%)
		DUF3513	612..817	CDD:288849	60/207 (29%)
Efs	NP_001099503.1	SH3_EFS	8..70	CDD:212936	28/71 (39%)
		DUF3513	372..556	CDD:288849	63/214 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10654
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	5.000