DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p130CAS and Bcar1

DIOPT Version :9

Sequence 1:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001382051.1	Gene:	Bcar1 / 25414	RGDID:	2406	Length:	874	Species:	Rattus norvegicus

Alignment Length:	932	Identity:	245/932 - (26%)
Similarity:	368/932 - (39%)	Gaps:	263/932 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 AKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVL-NSYDSGCF 145
            |||:|||.|::.|||.|:||||:||||:||:|..|||||||..|||:.|||||::| ..||....
  Rat     8 AKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPA 72

  Fly   146 SPSPA-----SSPVPSLAASTATLDSSICSAEIY----------ENGSVISAVSSSNSNSG---- 191
            :|.|.     ..|.|||.....|   .:..|..|          :..:|....:.|.:..|
  Rat    73 APGPGPPATPPQPQPSLPQGVHT---PVPPASQYSPMLPTAYQPQPDNVYLVPTPSKTQQGLYQA 134

  Fly   192 -----------------------------------------GA----------SSGLGSESVS-- 203
                                                     |:          |:|.|.:...
  Rat   135 PGPNPQFQSPPAKQTSTFSKQTPHHSFPSPATDLYQVPPGPGSPAQDIYQVPPSAGTGHDIYQVP 199

  Fly   204 -RVSRRSWHAS--PTKVITPQRHGDVYIYNYSPGSATGSGARAAPSTPQQQIY-SNQSIYQNFAM 264
             .:..|||..:  |.||:.|.|.|..|:|..|      ...:....||:..:. .:|.||.
  Rat   200 PSLDTRSWEGTKPPAKVVVPTRVGQGYVYEAS------QAEQDEYDTPRHLLAPGSQDIYD---- 254

  Fly   265 MSSPRQNASGSEF--ETYDIPKPATPVPLN-------YDSPRS---GLPKASNSTTTSSSSLGTR 317
             ..|.:....:::  |.||.|..|...|..       ||.|.|   |||.:::.:.
  Rat   255 -VPPVRGLLPNQYGQEVYDTPPMAVKGPNGRDPLLDVYDVPPSVEKGLPPSNHHSV--------- 309

  Fly   318 FETLKSVAASI------AEESYDVP-------------RPLILGS----NQLQQQMSQMTPSSSA 359
            ::...||:..:      .||:||||             .||||.:    :...:.:..:.|.:
  Rat   310 YDVPPSVSKDVPDGPLLREETYDVPPAFAKPKPFDPTRHPLILAAPPPDSPPAEDVYDVPPPA-- 372

  Fly   360 SSLLTSDSLSLSFSSSNRSSLANMPD----------YDIPRRNPLPVRRQQSGL----TYDFPLP 410
                              ..|.::|.          ||:||...||.......:    .|..| |
  Rat   373 ------------------PDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGSVIDDGVYAVP-P 418

  Fly   411 PLQEQVP---RVLCTPSTVTTTKEL-------------PLELSSALETLAKLQLQTTAAINRLLS 459
            |.:.:.|   :.|...||.:|....             ||||..|:||||:||...:..:..||.
  Rat   419 PAEREAPTDGKRLSASSTGSTRSSQSASSLEVVVPGREPLELEVAVETLARLQQGVSTTVAHLLD 483

  Fly   460 FV-----VPNWRTRAQ-LEPAIMDLKLAALRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPL 518
            .|     ...||:.:: .||.:.|||.|...:...:|:|.||...|:.:||.:.||.|..||...
  Rat   484 LVGSASGPGGWRSTSEPQEPPVQDLKAAVAAVHGAVHELLEFARSAVSSATHTSDRTLHAKLSRQ 548

  Fly   519 VRALRDANKLIHDSSESLDAQGAWSIDQLARSDEKHGCRPP----DALDQLMVCAQTLTEDVRST 579
            ::.:.|..:.:....:.||:                |...|    |.||:|:.|::.:.||.:..
  Rat   549 LQKMEDVYQTLVVHGQVLDS----------------GRGGPGFTLDDLDRLVACSRAVPEDAKQL 597

  Fly   580 TSFIQGNASLLFKRQLTVGHNGGSGT--------------------------------GVLEGSR 612
            .||:.|||||||:|....| .|..|:                                |..|.|.
  Rat   598 ASFLHGNASLLFRRTKAPG-PGPEGSSSLHLNPTDKASSIQSRPLPSPPKFTSQDSPDGQYENSE 661

  Fly   613 GSAEWLEDYDYVAFESKDAAARKNEALRE----------AIPADLKTQFDTVIRTAESSAMGAGS 667
            |.  |:||||||..:.|:...:..:.|.|          .:......||:   |..:..:.....
  Rat   662 GG--WMEDYDYVHLQGKEEFEKTQKELLEKGNIVRQGKGQLELQQLKQFE---RLEQEVSRPIDH 721

  Fly   668 GSIPTTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFI 732
            .....||   ..|..|.::..:...|::|:.:|.:|...::..|..|:|:|...|..|||||.|:
  Rat   722 DLANWTP---AQPLVPGRTGGLGPSDRQLLLFYLEQCEANLTTLTDAVDAFFTAVATNQPPKIFV 783

  Fly   733 AYGKFVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQ 797
            |:.|||::|||.||.|||.:.|......:|.::...:|.|.|.|:..|..:|.||..:||.||.|
  Rat   784 AHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQ 848

  Fly   798 EMVDSVVHINNLARDLKSVMLQ 819
            :|||.|..:.:..:..:.|:.|
  Rat   849 DMVDRVKELGHSTQQFRRVLGQ 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	37/53 (70%)
		Serine_rich_CAS	434..596	CDD:211403	55/171 (32%)
		DUF3513	612..817	CDD:288849	64/214 (30%)
Bcar1	NP_001382051.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337507
Domainoid	1	1.000	121	1.000	Domainoid score	I5561
eggNOG	1	0.900	-	-		E1_28I76
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3168
OMA	1	1.010	-	-		QHG46840
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	1	1.000	-	-		FOG0004232
OrthoInspector	1	1.000	-	-		otm63532
orthoMCL	1	0.900	-	-		OOG6_108346
Panther	1	1.100	-	-	O	PTHR10654
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2975
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810