DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p130CAS and Efs

DIOPT Version :9

Sequence 1:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_034242.2	Gene:	Efs / 13644	MGIID:	105311	Length:	560	Species:	Mus musculus

Alignment Length:	792	Identity:	188/792 - (23%)
Similarity:	278/792 - (35%)	Gaps:	282/792 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 AKSAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQD-TEGFQGWWLCSLRNRQGLCPGNRLRVL 137
            |.|||  .|:|:|||.|::..||.|::||:|.||::: ..|..||.||||..:||:.|.||:::|
Mouse     4 ATSAQ--LARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLL 66

  Fly   138 NSYDSGCFSPSPASSPVPSLAASTATLDSSICSAEIYENGSVISAVSSSNSNSGGASSGLGSESV 202
            .:        .||..|             |:|.
Mouse    67 PA--------GPAPKP-------------SLCP-------------------------------- 78

  Fly   203 SRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSATGSGARAAPSTPQQQIYSNQSIYQNFAMMSS 267
                     ||||:                |||                              |.
Mouse    79 ---------ASPTQ----------------PGS------------------------------SC 88

  Fly   268 PRQNASGSEFETYDIPKPATPVPLNYDSPRSGLPKASNSTTTSSSSLGTRFETLKSVAASIAEES 332
            |.......|.|.|.||.||.|      ...||||..|.|.::.|.....|...::..|:....|.
Mouse    89 PTPERGCEEQEVYVIPPPARP------CSASGLPARSCSPSSDSIYKVPRGNGMQLTASRDVAEV 147

  Fly   333 YDVPRPLILGSNQLQQQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVR 397
            |||| |.||           ..|||.                          .||.|
Mouse   148 YDVP-PNIL-----------RAPSSC--------------------------PYDSP-------- 166

  Fly   398 RQQSGLTYDFPLPPLQEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVV 462
                 .::..|:.|:..|.||          ..|.|.::..||:..|:|:..
Mouse   167 -----ASFSCPVAPVVPQPPR----------EDEAPYDVPLALKPPAELERD------------- 203

  Fly   463 PNWRTRAQLEPAIMDLKLAA---LRLRTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRD 524
            |.|....:..|.:    .||   |:..:.|.:|.|..|..|.|...                 ||
Mouse   204 PEWEGGREPGPPL----YAAPSNLKRASALLNLYEAPEELLANGES-----------------RD 247

  Fly   525 ANKLIHD---------SSESLDAQGAWSIDQLAR-----SDEKHGCRPP--DALDQLMVCAQTLT 573
            |::.|:|         |.|...|..:..:|.:|:     |..:|..|.|  ::|.:..:.|..::
Mouse   248 ADEGIYDVPLLGPEPPSPEPPVASSSTDLDTVAQLPTRSSPPQHRPRLPSTESLSRRPLPALPVS 312

  Fly   574 EDVRST--TSFIQGNASLLFKRQL------TVGHNGGSGTGVLE---------GSRGSAEWL--- 618
            |....:  .|...|....:..|.|      ..|:.|....|..|         |.....|.:
Mouse   313 EAPAPSPAPSPAPGRKGSIQDRPLPPPPPCLPGYGGLKPEGDPECREVANDPAGPHNEYEGIPMA 377

  Fly   619 EDYDYVAFESKDAAARKNEALREAIPADLKTQFDTVIRTAESSAMGAGSGSIPTTPTARTTPTTP 683
            |:||||..:..| .|:.:..|.:|.|.|.:.....:....|:.:        |..|...:|
Mouse   378 EEYDYVHLKGVD-TAQGSRPLDKAFPVDPELLERGLAERKEALS--------PEEPLVLST---- 429

  Fly   684 CKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTI 748
                    .|.:|:.:||.|..:|...|..|:.:.:.:.:.||||..|:.:||.|||:||.||.:
Mouse   430 --------GDLQLLHFYAGQCQSHYSALQAAVAALVASTQANQPPCLFVPHGKRVVVAAHRLVFV 486

  Fly   749 GDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLARDL 813
            ||.:.|..:..|||.::......|:..|:..||..|.||..:||.:|||||          ||.:
Mouse   487 GDTLGRLAASAALRAQVGAAGTMLAQTLRATVLAVKGAALGYPSDTAVQEM----------ARCV 541

  Fly   814 KSVMLQAVHLST 825
            ..:..||:..:|
Mouse   542 AELAGQALRFTT 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	26/55 (47%)
		Serine_rich_CAS	434..596	CDD:211403	37/188 (20%)
		DUF3513	612..817	CDD:288849	60/207 (29%)
Efs	NP_034242.2	SH3_EFS	8..70	CDD:212936	28/71 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..219		12/69 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..372		27/147 (18%)
		SH3-binding. /evidence=ECO:0000255	304..310		1/5 (20%)
		SH3-binding. /evidence=ECO:0000255	334..340		2/5 (40%)
		FAT-like_CAS_C	371..555	CDD:300863	63/214 (29%)
		Divergent helix-loop-helix motif	437..487		20/49 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10654
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	5.000