DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p130CAS and EFS

DIOPT Version :9

Sequence 1:	NP_001097456.2	Gene:	p130CAS / 38021	FlyBaseID:	FBgn0035101	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_005855.1	Gene:	EFS / 10278	HGNCID:	16898	Length:	561	Species:	Homo sapiens

Alignment Length:	796	Identity:	191/796 - (23%)
Similarity:	264/796 - (33%)	Gaps:	295/796 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 AKSAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQD-TEGFQGWWLCSLRNRQGLCPGNRLRVL 137
            |.|.|  .|:|:|||.|::..||.|::||:|.||::: ..|..||.||||..:||:.|.||:::|
Human     4 ATSTQ--LARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLL 66

  Fly   138 NSYDSGCFSPSPAS-SPVPSLAASTATLDSSICSAEIYENGSVISAVSSSNSNSGGASSGLGSES 201
                       ||. :|.|||:.
Human    67 -----------PAGPAPKPSLSP------------------------------------------ 78

  Fly   202 VSRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSATGSGARAAPSTPQQQIYSNQSIYQNFAMMS 266
                      |||                            |.|.:|.
Human    79 ----------ASP----------------------------AQPGSPY----------------- 88

  Fly   267 SPRQNASGSEFETYDIPKPATPVPLNYDSPRSG-----------LPKASNSTTTSSSSLGTRFET 320
             |..:.|..:.|.|.:|.||.|.|.:  .|.:|           :|:||          ||:.
Human    89 -PAPDHSNEDQEVYVVPPPARPCPTS--GPPAGPCPPSPDLIYKIPRAS----------GTQL-- 138

  Fly   321 LKSVAASIAEESYDVPRPLILGSNQLQQQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPD 385
               .|...|.|.|||| |..|           ..|||.                          .
Human   139 ---AAPRDALEVYDVP-PTAL-----------RVPSSG--------------------------P 162

  Fly   386 YDIPRRNPLPVRRQQSGLTYDFPLPPLQEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQLQT 450
            ||.|.....|       ||...|.||.::.      .|..|..|.:.|.||...||
Human   163 YDCPASFSHP-------LTRVAPQPPGEDD------APYDVPLTPKPPAELEPDLE--------- 205

  Fly   451 TAAINRLLSFVVPNWRTRAQLEPAI----MDLKLAA--LRLRTTLHDLAEFGEGALGNATRSEDR 509
                          |....:..|.|    .:||.|:  |.|.....:|...|||.      ..|
Human   206 --------------WEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGG------GTD- 249

  Fly   510 NLALKLRPLVRALRDANKLIHDSSESLDAQGAW-SIDQ------LARS-DEKHGCRPPDA----- 561
                      ..:.|...|..::..|.:..||. |.||      |||| ...|..|.|.|
Human   250 ----------EGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSR 304

  Fly   562 --LDQLMVCAQTLTEDVRSTTSFIQGNASLLFKRQL------TVGHNGGSGTGVLEGSRGSAEWL 618
              |..|.|........|.|..   .|....:..|.|      ..|:.|....|..||..     :
Human   305 RPLPALPVPEAPSPSPVPSPA---PGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGRE-----M 361

  Fly   619 EDYDYVAFESKDAAARKNEALREAIPADLKTQFDTVIRTAESSAMGA--------GSGSIP---- 671
            ||         |.|...||  .|.||  :..::|.|.......|.|:        |...:|
Human   362 ED---------DPAGHHNE--YEGIP--MAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGM 413

  Fly   672 TTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGK 736
            ..|....:|..|.   .::..|.:|:.:||.|..:|...|..|:.:.:.:.:.||||:.|:.:.|
Human   414 PAPQEALSPGEPL---VVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSK 475

  Fly   737 FVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVD 801
            .|||:||.||.:||.:.|..:...||.::.....||..||:..||..|.||..:||..|:||||.
Human   476 RVVVAAHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQ 540

  Fly   802 SVVHINNLARDLKSVM 817
            .|..:...|....:::
Human   541 CVTELAGQALQFTTLL 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	26/55 (47%)
		Serine_rich_CAS	434..596	CDD:211403	41/188 (22%)
		DUF3513	612..817	CDD:288849	62/216 (29%)
EFS	NP_005855.1	SH3_EFS	8..70	CDD:212936	30/74 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..123		22/154 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..215		15/79 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..372		39/167 (23%)
		SH3-binding. /evidence=ECO:0000255	305..311		1/5 (20%)
		SH3-binding. /evidence=ECO:0000255	335..341		2/5 (40%)
		DUF3513	372..556	CDD:288849	56/188 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..422		5/31 (16%)
		Divergent helix-loop-helix motif	438..488		19/49 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10654
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	4.000