Protein Alignment p130CAS and EFS

DIOPT Version :10

• Sequence 1: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_005855.1
• Gene: EFS / 10278
• HGNCID: 16898
• Length: 561
• Species: Homo sapiens
• Alignment Length: 796
• Identity: 191/796 - (23%)
• Similarity: 264/796 - (33%)
• Gaps: 295/796 - (37%)

  Fly    74 AKSAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQD-TEGFQGWWLCSLRNRQGLCPGNRLRVL 137
            |.|.|  .|:|:|||.|::..||.|::||:|.||::: ..|..||.||||..:||:.|.||:::|
Human     4 ATSTQ--LARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLL 66

  Fly   138 NSYDSGCFSPSPAS-SPVPSLAASTATLDSSICSAEIYENGSVISAVSSSNSNSGGASSGLGSES 201
                       ||. :|.|||:.
Human    67 -----------PAGPAPKPSLSP------------------------------------------ 78

  Fly   202 VSRVSRRSWHASPTKVITPQRHGDVYIYNYSPGSATGSGARAAPSTPQQQIYSNQSIYQNFAMMS 266
                      |||                            |.|.:|.
Human    79 ----------ASP----------------------------AQPGSPY----------------- 88

  Fly   267 SPRQNASGSEFETYDIPKPATPVPLNYDSPRSG-----------LPKASNSTTTSSSSLGTRFET 320
             |..:.|..:.|.|.:|.||.|.|.:  .|.:|           :|:||          ||:.
Human    89 -PAPDHSNEDQEVYVVPPPARPCPTS--GPPAGPCPPSPDLIYKIPRAS----------GTQL-- 138

  Fly   321 LKSVAASIAEESYDVPRPLILGSNQLQQQMSQMTPSSSASSLLTSDSLSLSFSSSNRSSLANMPD 385
               .|...|.|.|||| |..|           ..|||.                          .
Human   139 ---AAPRDALEVYDVP-PTAL-----------RVPSSG--------------------------P 162

  Fly   386 YDIPRRNPLPVRRQQSGLTYDFPLPPLQEQVPRVLCTPSTVTTTKELPLELSSALETLAKLQLQT 450
            ||.|.....|       ||...|.||.::.      .|..|..|.:.|.||...||
Human   163 YDCPASFSHP-------LTRVAPQPPGEDD------APYDVPLTPKPPAELEPDLE--------- 205

  Fly   451 TAAINRLLSFVVPNWRTRAQLEPAI----MDLKLAA--LRLRTTLHDLAEFGEGALGNATRSEDR 509
                          |....:..|.|    .:||.|:  |.|.....:|...|||.      ..|
Human   206 --------------WEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGG------GTD- 249

  Fly   510 NLALKLRPLVRALRDANKLIHDSSESLDAQGAW-SIDQ------LARS-DEKHGCRPPDA----- 561
                      ..:.|...|..::..|.:..||. |.||      |||| ...|..|.|.|
Human   250 ----------EGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSR 304

  Fly   562 --LDQLMVCAQTLTEDVRSTTSFIQGNASLLFKRQL------TVGHNGGSGTGVLEGSRGSAEWL 618
              |..|.|........|.|..   .|....:..|.|      ..|:.|....|..||..     :
Human   305 RPLPALPVPEAPSPSPVPSPA---PGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGRE-----M 361

  Fly   619 EDYDYVAFESKDAAARKNEALREAIPADLKTQFDTVIRTAESSAMGA--------GSGSIP---- 671
            ||         |.|...||  .|.||  :..::|.|.......|.|:        |...:|
Human   362 ED---------DPAGHHNE--YEGIP--MAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGM 413

  Fly   672 TTPTARTTPTTPCKSPEMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGK 736
            ..|....:|..|.   .::..|.:|:.:||.|..:|...|..|:.:.:.:.:.||||:.|:.:.|
Human   414 PAPQEALSPGEPL---VVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSK 475

  Fly   737 FVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVD 801
            .|||:||.||.:||.:.|..:...||.::.....||..||:..||..|.||..:||..|:||||.
Human   476 RVVVAAHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQ 540

  Fly   802 SVVHINNLARDLKSVM 817
            .|..:...|....:::
Human   541 CVTELAGQALQFTTLL 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	26/55 (47%)
		Serine_rich_CAS	434..596	CDD:211403	41/188 (22%)
		CAS_C	611..817	CDD:463437	62/217 (29%)
EFS	NP_005855.1	SH3_EFS	8..70	CDD:212936	30/74 (41%)
		PHA03307	67..>205	CDD:223039	55/303 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..123		22/154 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..215		15/79 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..372		39/167 (23%)
		SH3-binding. /evidence=ECO:0000255	305..311		1/5 (20%)
		SH3-binding. /evidence=ECO:0000255	335..341		2/5 (40%)
		CAS_C	371..556	CDD:463437	57/191 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..422		5/31 (16%)
		Divergent helix-loop-helix motif	438..488		19/49 (39%)