Protein Alignment p130CAS and efs

DIOPT Version :9

• Sequence 1: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_001311337.1
• Gene: efs / 100333297
• ZFINID: ZDB-GENE-030131-1658
• Length: 990
• Species: Danio rerio
• Alignment Length: 1065
• Identity: 242/1065 - (22%)
• Similarity: 369/1065 - (34%)
• Gaps: 392/1065 - (36%)

  Fly    76 SAQKLYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVLNSY 140
            |...:.|||::||.|::.:||.|:|||||.||.|:.:|..|||||||..|||:.|.||||:|.|
Zfish     2 SLSTVLAKALFDNAAESPEELAFRKGDILMVLNQEQDGGPGWWLCSLHGRQGIAPANRLRLLQS- 65

  Fly   141 DSGCFSPSPASSPVPSLAASTATLDSSICSAEI--YENGSVISAVSSSNSNSGGASSG--LGSES 201
                 :.:||||     |.:.|....|:.|..:  .:.|.|       |..|...|.|  |...|
Zfish    66 -----TQAPASS-----AGTDARRAPSVDSVHLPSSQQGKV-------NGLSAEDSDGVYLSPPS 113

  Fly   202 VSRVSRRSWHASPTKVITPQ-RHGDVYIYNYSPGSATGSGAR----------------------- 242
            ::....:|..|:|.:..:.: ||.|.    ..|.|.:.||.|
Zfish   114 LAEGVYQSPGAAPAQCRSGELRHSDA----GRPRSHSSSGTRPRPDWGDVGVAGRPRSPSLRGRG 174

  Fly   243 -------AAPSTP--------QQQIYSNQSIYQNFAMMS-------------SPRQNASGSEFET 279
                   ..||:|        .|......|:|...:.:|             |||..::|.....
Zfish   175 GESGTLYQTPSSPVPLAAQHRSQVALPTDSVYLTPSAVSRSAAETAGESRYLSPRDASAGHSDGC 239

  Fly   280 YDIPKPATPVPLN---YDSPRSGLPKAS----------------NSTTTSSSSLGTRFETLKSVA 325
            |.:|:||.....:   |.:|.||.|.|.                .|:.:||||      ..:|.:
Zfish   240 YLVPRPAVTTLTSENLYQTPTSGAPVAGQCVAGVTSRLVDKIAPKSSPSSSSS------PSQSKS 298

  Fly   326 ASIAEESYDVPRP--------------------LILGSNQLQQQMSQMTPSSSASSLLTSDSLSL 370
            ...|...|..|.|                    ::..::...|.:.|..||...|...|:
Zfish   299 GQDAPGMYQTPTPPGGAISRTPQSDRKNPAGTVVVSNASTPGQNIKQTPPSGRGSQKGTT----- 358

  Fly   371 SFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGL--TYDF------PLPPL----QEQVPRVLCTP 423
            |.:...|..|         |.:||..|..:||:  :.:|      |.||:    ::.:|:....|
Zfish   359 STAPVGRGKL---------RESPLLTRTGKSGVPSSPNFGRKPPPPAPPVRSVTRKDLPQSSAIP 414

  Fly   424 STVTTTKELPL----------------------ELSSALETLAKL------------QLQTTAAI 454
            :|....:..|.                      |:.:..|.|:|.            ::..|...
Zfish   415 ATKPVLQANPAPPPTNMLEEERQGSKSGQTQADEMKNNSEMLSKRDSASSQEEKLSEEVYDTPPT 479

  Fly   455 NRLLSFVVPNWRTRAQLEPAIMD--------------------LKLAALRLRTTLHDLAEF---- 495
            ||        |:....:.|:..|                    ..:..|.|.::.|....:
Zfish   480 NR--------WQHPVSIVPSEEDDGIYNTPRALIVHNDQASEIYDVPTLALNSSEHQQQTYNIPG 536

  Fly   496 GEGALGNATRSEDRNL----ALKLRPLVRALRDANKLIHDSSESLDAQGAWSIDQLARSDEKHGC 556
            ...|:|:|   ||.::    :|...||     :|::|...:.|::....::||..|.:.|.....
Zfish   537 SAAAIGDA---EDEDVYSVPSLPGLPL-----EASELSGLTVETVVNGRSYSISSLRKQDAIDDV 593

  Fly   557 RPPDA----LDQLMVCAQTLTEDVRSTTS-FIQGNASL--LFKRQLT------------------ 596
            ..||.    :..|.:...|....|.||.| .||...||  |.:..||
Zfish   594 SEPDGGIYDMPALNLEIPTRRLSVSSTGSGDIQWKTSLSALVQSALTSASLPTTPSRDFAAALAE 658

  Fly   597 ------VGHNGG---------------------SGT-----GVLEGSRGSAEWLEDYDYVAFESK 629
                  .||.|.                     .||     |:|...||:.|
Zfish   659 ILSIWKAGHVGDIPPVLQHAWSRLSDLLPALSVCGTAPPADGLLSMVRGALE------------- 710

  Fly   630 DAAARKNEALREAIPADLKTQFDTVIR-------TAE----SSAMGAGSGS------IPTTPTAR 677
            |:||......|..:|:.     |::.|       .||    :..||:..||      :|..|.|.
Zfish   711 DSAALLQSQTRPRLPSQ-----DSLSRRPLPALPVAEVKPIAGDMGSRKGSWIQERPLPPPPPAA 770

  Fly   678 ------------------------------TTPTTPCKSP------------------------- 687
                                          .|||.|...|
Zfish   771 FPLPPAPVSLVPTVGRMEDEEPGNEYAGIGLTPTPPPSYPVGDSVGYVKLQGKPEPPPDTHTEHS 835

  Fly   688 ------------------EMTDKDKKLVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAY 734
                              .|:.:|.:|:.:|:.|..:|:..|..||||...:|:.||||:.|::.
Zfish   836 SSQLITSTDNKLSPSPPVSMSLEDSELLSFYSSQSLSHLSCLADAIDSLFTSVQGNQPPRVFVSR 900

  Fly   735 GKFVVVSAHNLVTIGDNVYRNISKEALREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEM 799
            ||.::|:||.||.|||.:.|.:|...||.|:...:..|..|||..|:.:|.||.::||..|.|||
Zfish   901 GKSLIVTAHKLVFIGDTLARLLSSSDLRAKVTTSSGRLCQALKAVVVATKGAAQNYPSVPATQEM 965

  Fly   800 VDSVVHINNLARDLKSVMLQAVHLS 824
            ||.|..::..|.....::.:...:|
Zfish   966 VDRVADLSQHAAGFSGLLQRLAEIS 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	32/54 (59%)
		Serine_rich_CAS	434..596	CDD:211403	41/230 (18%)
		DUF3513	612..817	CDD:288849	74/294 (25%)
efs	NP_001311337.1	SH3	6..66	CDD:302595	35/65 (54%)
		FAT-like_EFS_C	858..987	CDD:211412	49/128 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10654
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.040