DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dic61B and DYNC2I2

DIOPT Version :9

Sequence 1:NP_728477.1 Gene:Dic61B / 38020 FlyBaseID:FBgn0263988 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_443076.2 Gene:DYNC2I2 / 89891 HGNCID:28296 Length:536 Species:Homo sapiens


Alignment Length:517 Identity:117/517 - (22%)
Similarity:193/517 - (37%) Gaps:113/517 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   251 VSSYVSNFEMYDTLNNITKEFATATMSSVKDLTSALAQTED-ADTFEDDEA---VAEKDKVSSQI 311
            |:|..|.:.....:...||...||::::    .||.||..: .|.....||   |:.:......|
Human    45 VASVPSQWRAVQGIRWETKSCQTASIAT----ASASAQARNHVDAQVQTEAPVPVSVQPPSQYDI 105

  Fly   312 ERLFRSPEFRNAIMYMGRTLSSNTNEAGLRRFRNFDQVE-RWNAEAEYVYSMNLLFRLVPEPSKD 375
            .||  :...|.....:.|.|:.|...      ..||..| .|..:.:.|   :.|:.|...|::.
Human   106 PRL--AAFLRRVEAMVIRELNKNWQS------HAFDGFEVNWTEQQQMV---SCLYTLGYPPAQA 159

  Fly   376 ERKAVSDIDFCRSNGDILAVAYG---------LYSFSSQHVPTSGSVFLWSIK----NPGEPERA 427
            :...|:.|.: .|.|.::|.|||         |.||          |..|::.    .|.:|...
Human   160 QGLHVTSISW-NSTGSVVACAYGRLDHGDWSTLKSF----------VCAWNLDRRDLRPQQPSAV 213

  Fly   428 YYYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQV 492
            ......|..:.|.|..||.:|.|||.|.|.|.|:|.|:|               |::   |...:
Human   214 VEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLED---------------PLL---WRTGL 260

  Fly   493 SDDDHETDIDPFLSLSQDGSVTRFRIIK----SPFLL----GFTQMILERVEGHPEGIFVHPSSR 549
            :||.|...:...:.|.:.|...||:::.    ...||    |..|  |:..||     |.....:
Human   261 TDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQ--LQLTEG-----FALVMQQ 318

  Fly   550 IP--CESNRHPQG------LSITTHPLHKDIYYVLTDEGCIHKCSINYQHQYLE------VLRC- 599
            :|  .:..:||:|      .::........::.:.|:.|...|||:......|.      .||. 
Human   319 LPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAP 383

  Fly   600 -------HDGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHS 657
                   |.|.:..:..||:...|||:.|.|..|.::......||..|...:..:...:|||...
Human   384 AQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRP 448

  Fly   658 TIIVTVN-RETANVWDFRRNLLRP--MSKHKMDSS------FNTVARFSHCGRTLVIGNERG 710
            .:....: :....::|.:::..:|  :.|...|.|      ||     |...:.|..|:.:|
Human   449 LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFN-----SQQTQLLAAGDAQG 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dic61BNP_728477.1 WD40 358..730 CDD:225201 91/405 (22%)
WD40 repeat 381..429 CDD:293791 14/60 (23%)
WD40 433..711 CDD:295369 72/317 (23%)
WD40 repeat 434..473 CDD:293791 16/38 (42%)
WD40 repeat 552..599 CDD:293791 10/58 (17%)
WD40 repeat 604..637 CDD:293791 8/32 (25%)
WD40 repeat 645..682 CDD:293791 5/39 (13%)
WD40 repeat 691..727 CDD:293791 5/20 (25%)
DYNC2I2NP_443076.2 DYNLL2 binding. /evidence=ECO:0000269|PubMed:30649997 80..93 3/12 (25%)
WD40 106..516 CDD:225201 101/452 (22%)
DYNLRB1 binding. /evidence=ECO:0000269|PubMed:30649997 106..131 6/32 (19%)
WD40 repeat 164..215 CDD:293791 15/61 (25%)
WD 1. /evidence=ECO:0000255 215..255 17/54 (31%)
WD40 217..515 CDD:295369 72/319 (23%)
WD40 repeat 220..264 CDD:293791 19/61 (31%)
WD 2. /evidence=ECO:0000255 264..308 10/45 (22%)
WD40 repeat 270..325 CDD:293791 13/61 (21%)
WD40 repeat 337..389 CDD:293791 8/51 (16%)
WD 3. /evidence=ECO:0000255 390..430 12/39 (31%)
WD40 repeat 396..432 CDD:293791 10/35 (29%)
WD 4. /evidence=ECO:0000255 433..473 4/39 (10%)
WD40 repeat 438..476 CDD:293791 5/37 (14%)
WD 5. /evidence=ECO:0000255 480..520 8/31 (26%)
WD40 repeat 485..512 CDD:293791 6/26 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1587
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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