DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic61B and Dnai1

DIOPT Version :9

Sequence 1:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_780347.2	Gene:	Dnai1 / 68922	MGIID:	1916172	Length:	701	Species:	Mus musculus

Alignment Length:	756	Identity:	166/756 - (21%)
Similarity:	313/756 - (41%)	Gaps:	138/756 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ELKKKSVVVN---QTQAEESKAKKKDTTHYYSVETLADLQYRSQIKVLEKIYGEEVDM------- 81
            :::|:|:.|.   :.:.|:|.....:.|..:| ::.|.::...|:::.:....||...
Mouse     5 QIRKQSISVTRGARRRDEDSGTDVGEGTDEWS-QSKATVRPPDQLELTDAELKEEFTRILTANNP 68

  Fly    82 -TPKSIQDDTYVEQFMKYNLNVMHQM-TNFT---TMVAKSTTRSRTRSSVRAGIGGNKQSIDDLM 141
             .|::|...::.|...|. :..::|| .:|:   .::.|.:...|.:......:.|:::||..:.
Mouse    69 HAPQNIVRYSFKEGTYKL-IGFVNQMAVHFSQVGNLIPKDSDEGRRQHYRDEMVAGSQESIKVVT 132

  Fly   142 NGILYETINWEPYSTVEALEEAYEPKPYTKSFLKITLRKSDFFEIHSQTQTTVAKGS----PEGD 202
                         |..|.|||..|||                 |...:.:.....||    |...
Mouse   133 -------------SEAENLEEEEEPK-----------------EGEGEAEAEAEAGSQTDIPAAA 167

  Fly   203 DAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTI------------LITKATVSSYV 255
            :........|.:...:.|.|:      .|:...|:.||..|.            ...:...|:..
Mouse   168 ETTEKVIEEELMAPVQPKERK------LTNQFNFSERASQTFNNPLRDRECQMEPPPRTNFSATA 226

  Fly   256 SNFEMYDT-LNNITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKDKVSSQIERLFRSPE 319
            :.:|:||. ::.:.|:..|......|  |....:||..       |:.:...:.||.:.:.:..:
Mouse   227 NQWEIYDAYVDELEKQEKTKEKEKAK--TPVAKKTEKM-------AMRKLTSMESQSDDITKVTQ 282

  Fly   320 FRNAIMYMGRTLSSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNLLFRLVP-EPSKDERKAVSDI 383
               |...:.|.::.||.:...:.|:.::     :...||......|..|.. :..|.:|.||:.:
Mouse   283 ---AAKIVERMVNQNTYDDVAQDFKYYE-----DTADEYRDQEGTLLPLWKFQNDKAKRLAVTAL 339

  Fly   384 DFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAYYYDVPVTAINFSPFLPSLLA 448
            .:.....|:.||.:|.|.|..|   :.|.:.|:|:|||..||..:..:..:..::.....|.|:.
Mouse   340 CWNPKYKDLFAVGHGSYDFMKQ---SRGMLLLYSMKNPSFPEYMFSSESGIMCLDVHVDHPYLVV 401

  Fly   449 IGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDHETDIDPFLSLSQDGSV 513
            :|.|||:|.:.::......|...|...:...:.||..::|  |..|.||..:   |.|:|.||.:
Mouse   402 VGYYDGNVAIYNLKKPHSQPCFRSTSKSGKHTDPVWQVKW--QKDDMDHNLN---FFSVSSDGRI 461

  Fly   514 TRFRIIKSPFLLGFTQMILERVEGH----PEGIFVHPSSRIPCESNRHPQGLSITTHPLHKDIYY 574
            ..:.::||.  |....:|..:.||.    |||:.:|   .:.|.          |....||:|.|
Mouse   462 VSWTLVKSE--LVHIDIIKLKTEGSTTEIPEGLQLH---TVGCG----------TAFDFHKEIDY 511

  Fly   575 VL---TDEGCIHKCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDGITRP 636
            :.   |:||.|:|||.:|..|:|:....|:..|..:.::|:..|:|::|.:||.|:||...|..|
Mouse   512 MFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMAVDAVLWNPYHTKVFMSCSSDWTVKIWDHTIKTP 576

  Fly   637 LLELLDEMTPVHWAKWSPTHSTIIVTVNRE-TANVWDFRRNLLRPM--------SKHKMDSSFNT 692
            :. :.|..:.|....|:|..||:...|..: .|:|:|...|....:        .|:|:     |
Mouse   577 MF-IYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHVFDLAVNKYEAICNQPVVAKKKNKI-----T 635

  Fly   693 VARFSHCGRTLVIGNERGNTLFNALNDMPFSPHFQYDELEK 733
            ..:|:.....:::|::||:.:.     :..||:.:....||
Mouse   636 HVQFNPIHPIIIVGDDRGHIIC-----LKLSPNLRKMPKEK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	102/388 (26%)
		WD40 repeat	381..429	CDD:293791	15/47 (32%)
		WD40	433..711	CDD:295369	77/293 (26%)
		WD40 repeat	434..473	CDD:293791	8/38 (21%)
		WD40 repeat	552..599	CDD:293791	16/49 (33%)
		WD40 repeat	604..637	CDD:293791	11/32 (34%)
		WD40 repeat	645..682	CDD:293791	10/45 (22%)
		WD40 repeat	691..727	CDD:293791	7/35 (20%)
Dnai1	NP_780347.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..165		14/75 (19%)
		WD40	321..679	CDD:225201	102/385 (26%)
		WD40 repeat	336..382	CDD:293791	16/48 (33%)
		WD40	<354..612	CDD:295369	81/281 (29%)
		WD 1	382..422		7/39 (18%)
		WD40 repeat	388..429	CDD:293791	9/40 (23%)
		WD 2	431..474		15/49 (31%)
		WD40 repeat	436..493	CDD:293791	20/63 (32%)
		WD40 repeat	501..538	CDD:293791	15/36 (42%)
		WD 3	539..579		13/40 (33%)
		WD40 repeat	544..581	CDD:293791	12/37 (32%)
		WD 4	581..621		11/39 (28%)
		WD40 repeat	586..627	CDD:293791	10/40 (25%)
		WD 5	629..668		9/48 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5611
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42488
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5769
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.790